Di-iron-based mesoporous carbon nanomaterials integrating nuclear magnetic imaging contrast and drug delivery functions, its preparation method and application
A carbon nanomaterial and magnetic imaging technology, applied in the direction of nuclear magnetic resonance/magnetic resonance imaging contrast agents, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve poisoning and easily induce nephrogenic system problems such as permanent fibrosis and signal loss, and achieve the effect of simple and effective preparation technology, good biological safety, and avoiding nanoparticle agglomeration
Active Publication Date: 2021-09-28
FUDAN UNIV
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Problems solved by technology
Studies have found that gadolinium-based contrast agents are likely to induce nephrogenic systemic fibrosis during use in patients with kidney disease. At the same time, because gadolinium is a heavy metal, it will cause side effects such as poisoning and metal deposition during long-term use. Therefore, an alternative to gadolinium was developed. Contrast agents used in T 1 Weighted imaging is imminent
Iron is an essential element for the human body and has relatively good biocompatibility. A large number of reports have shown that T can be improved by adjusting the size of iron-based nanoparticles. 1 weighted imaging effect, but this will inevitably lead to T 2 loss of signal
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Embodiment 1
[0040] 1) Dissolve 0.1g F127 or equivalent P123 into 5g tetrahydrofuran solution, then add 0.6g (20wt.%) resole phenolic resin, and stir at room temperature for 0.5h. Take 24mg{Fe 9 P 3} clusters were dissolved in 5 g tetrahydrofuran solution and added to the above solution, and the mixed solution was stirred at room temperature for 2 h to obtain a uniform reddish-brown transparent solution.
[0041] 2) Transfer the solution to a petri dish, volatilize tetrahydrofuran at room temperature for 8 hours, and then place the petri dish in an oven at 100° C. for 24 hours to obtain a transparent dark red film material.
[0042] 3) Scrape off the material from the petri dish, grind it into powder, place the sample in a tube furnace, and bake it at 600°C for 3 hours under the protection of high-purity nitrogen in an inert atmosphere, with a nitrogen flow rate of 90ml min –1 , the heating rate is 1°C·min –1 , to obtain bis-iron-based mesoporous carbon nanomaterials.
[0043] The foll...
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Abstract
The invention relates to the technical field of functional nanomaterials, in particular to a double-iron-based mesoporous carbon nanomaterial integrating nuclear magnetic imaging and drug delivery functions and a preparation method thereof. The double-iron-based mesoporous carbon nanomaterial contains paramagnetic nanoparticles Iron phosphate and superparamagnetic nanoparticles gamma iron oxide, iron metaphosphate and gamma iron oxide nanoparticles are uniformly dispersed in the mesoporous carbon skeleton, the particle size is adjustable from 1 to 20nm, iron metaphosphate and gamma iron oxide are in The mass content of the mesoporous carbon nanomaterial is 0.5% to 10%, and the molar ratio of iron metaphosphate to gamma iron oxide is 1:4. The nanometer material provided by the invention realizes T 1 / T 2 The MRI imaging function and the drug delivery function are integrated, and have the characteristics of low cytotoxicity. At the same time, the preparation method of the nano-diagnosis and treatment material provided by the invention is simple, and the raw materials are widely available, so it has potential application prospects.
Description
technical field [0001] The invention relates to the technical field of functional nanomaterials, in particular to a double-iron-based mesoporous carbon nanomaterial integrating nuclear magnetic imaging imaging and drug delivery functions, and a preparation method and application thereof. Background technique [0002] Nanomaterials integrating diagnosis and treatment are composite biomedical materials that integrate disease diagnosis and treatment functions. They are the development direction of precision medicine, and their research has attracted more and more attention from researchers in many fields. There are two types of MRI contrast agents: paramagnetic T 1 Weighted contrast agents and superparamagnetic T 2 Weighted contrast agent. Combining MRI contrast agents with porous materials with drug-loading function is a feasible method to develop integrated nanomaterials for diagnosis and treatment. [0003] Mesoporous carbon is a kind of porous material with mesoscopic or...
Claims
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IPC IPC(8): A61K49/08A61K9/51A61K47/04A61K31/704C01B32/15A61P35/00B82Y5/00B82Y25/00B82Y40/00
CPCA61K9/5115A61K31/704A61K49/08A61P35/00B82Y5/00B82Y25/00B82Y40/00C01B32/15
Inventor 凌云周亚明张慧陈珍霞刘小锋杨永泰贾瑜
Owner FUDAN UNIV