Application of magnesium isoglycyrrhizinate to preparation of medicine for treating colitis

A kind of technology of magnesium isoglycyrrhizinate and colitis, applied in the application field of magnesium isoglycyrrhizinate in the preparation of medicine for treating colitis

Inactive Publication Date: 2020-12-08
南京澳特飞吉生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there is no report about its unique pharmacological effects in the treatment of colitis

Method used

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  • Application of magnesium isoglycyrrhizinate to preparation of medicine for treating colitis
  • Application of magnesium isoglycyrrhizinate to preparation of medicine for treating colitis
  • Application of magnesium isoglycyrrhizinate to preparation of medicine for treating colitis

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Embodiment 1

[0023] 1. Pharmacological experiment of magnesium isoglycyrrhizinate injection: DSS-induced colitis model in mice[1]

[0024] C57BL / 6 female mice, aged 6-8 weeks, weighing 22-24 g, were raised in an SPF animal room at 21±2°C, with free access to water and food, and alternated day and night for 12 hours. Mice were randomly divided into 5 groups, normal group (Sham group), model group (DSS group), magnesium isoglycyrrhizinate (Magnesium Isoglycyrrhizinate, MIG) low, medium and high dose groups (1.25mg / kg, 2.5mg / kg, 5mg / kg kg). The mice in the model group and the administration group were fed with 2.5% DSS for 7 days, followed by 2 days of water recovery. The administration group was intraperitoneally administered according to the dose, once a day, 200 μl each time. Afterwards, the body weight of the mice was recorded every day and the disease activity index (DAI) was scored, and the mice were sacrificed on the 9th day, and then the length of the colon and histopathological sec...

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Abstract

The invention belongs to the technical field of pharmacy, and relates to an application of magnesium isoglycyrrhizinate to preparation of a medicine for treating colitis. In a disease model of mouse acute and chronic enteritis induced by dextran sodium sulfate DSS, the magnesium isoglycyrrhizinate can effectively improve the conditions of weight loss, diarrhea, hemafecia and colonic shortening ofmice, reduce inflammatory cell infiltration and the expression level of inflammatory factors in the colons of the mice, maintain the intestinal epithelial barrier integrity, increase connexins Zo-1, occludin and E-caderin, reduce the Claudin-2 expression level, and reduce fibrosis caused by colitis. It is found for the first time that the magnesium isoglycyrrhizinate can treat colitis, clinical application of the magnesium isoglycyrrhizinate is increased, and remarkable popularization value is achieved.

Description

technical field [0001] The invention relates to a new application of magnesium isoglycyrrhizinate, in particular to the application of magnesium isoglycyrrhizinate in medicine for treating colitis. Background technique [0002] Inflammatory bowel disease is a chronic "incurable disease", which has the characteristics of complex etiology, easy recurrence and difficult to cure. Inflammatory bowel disease is divided into ulcerative colitis and Crohn's disease. The clinical features of colitis are mainly recurrent diarrhea and ulcers, accompanied by inflammatory cell infiltration, secretion of IL-6, TNF-α and other cytokines. At present, there are not many clinical drug treatment options, and the existing drugs have large side effects, and a large part of patients do not respond in clinical treatment. [0003] Magnesium isoglycyrrhizinate injection was developed as a hepatoprotective drug, and the research on this compound mainly focused on chronic viral hepatitis. So far, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61K9/08A61P1/00A61P29/00A61P1/04
CPCA61K31/704A61K9/08A61K9/0019A61P1/00A61P29/00A61P1/04
Inventor 郭文洁徐强崔建
Owner 南京澳特飞吉生物科技有限公司
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