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Application of arabinose and composition for intestinal tract preparation

A technology of arabinose and composition, applied in the field of use and composition for intestinal preparation, can solve the problems of affecting psychology, large intestinal irritation, far from achieving the preparation effect and the like

Active Publication Date: 2020-12-18
唐传生物科技(厦门)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Magnesium sulfate is a commonly used intestinal preparation drug recommended in clinical practice. Magnesium sulfate has the advantages of simple method and low price. However, magnesium sulfate salt is very irritating to the intestinal tract, and it is easy to cause adverse reactions such as nausea, vomiting and abdominal distension. In addition, magnesium sulfate It can change the morphology of intestinal mucosa and lead to increased permeability of intestinal mucosa, leading to intestinal mucosal damage
In addition, magnesium sulfate also has unsatisfactory bowel cleansing effect, which cannot achieve the effect of colonoscopy observation, causing patients to repeat the bowel preparation process, which not only affects the patient's psychology of bowel preparation before colonoscopy, greatly reduces the patient's compliance, and far Failure to achieve the preparation effect stated in the drug instructions will increase the medical burden of colonoscopy

Method used

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  • Application of arabinose and composition for intestinal tract preparation
  • Application of arabinose and composition for intestinal tract preparation
  • Application of arabinose and composition for intestinal tract preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] This example examines bowel preparation

[0064] Evaluation criteria for bowel preparation:

[0065] The Ottawa score scores bowel readiness in two parts. One is to divide the colon into 3 segments (left colon LC: rectum-sigmoid colon, middle colon TC: transverse colon-descending colon, right colon RC: ascending colon and cecum) and score the cleanliness of each segment. The second is to score the residual fluid in the whole colon. The Ottawa score divides the intestinal cleanliness into 5 grades (0-4 points respectively) according to clean-worst. 0 is the best: the intestinal preparation is satisfactory, there is no fecal residue in the intestinal cavity, no fecal water retention, the intestinal juice is very clear, the operation process is smooth and the mucosal observation is good; 1 is better: the intestinal preparation is comparative Satisfactory, there is a little fecal residue in the intestinal cavity, a little fecal water retention, no need for washing and su...

Embodiment 2

[0083] Investigate the effects of magnesium sulfate and L-arabinose on the excretion of mice

[0084] experimental method

[0085] Experimental animals and their feeding: C57BL / 6J mice, specific pathogen free (Specific pathogen Free, SPF) level, male, 6 weeks old; common feed is D12450-B feed: carbohydrate 67.35wt%, crude protein 19.2wt%, Fat 4.3 wt%. The room temperature is maintained at 24-26°C and the humidity is 40-60%.

[0086] Constipation model establishment in mice: Mice were intragastrically given loperamide suspension 9 mg / kg. body weight, twice a day, doubling the first administration, for 8 consecutive days, to establish constipated mice.

[0087] Experimental investigation:

[0088] The constipated mice were randomly divided into model group, experimental group 1, experimental group 2 and experimental group 3, with 8 mice in each group. In addition, 8 normal healthy non-constipated mice were randomly selected as the blank control group.

[0089] The mice in e...

Embodiment 3

[0096] This example investigates how L-arabinose can improve intestinal mucosal damage caused by magnesium sulfate (short-term simulation of large doses of magnesium sulfate intestinal preparation administration)

[0097] The intestinal mucosa is the largest contact surface between the internal environment of the animal body and the substances in the intestinal cavity. It not only has the function of absorbing nutrients, but also has a barrier function to prevent pathogenic bacteria and food antigens in the intestine from invading the body. As an important component of the body's defense against pathogen infection and inflammation, the intestinal mucosal barrier is of great significance for maintaining the homeostasis of the body's internal environment.

[0098] Increased intestinal mucosal permeability is an indicator that indirectly reflects the damage of the intestinal mucosal mechanical barrier, which can be detected by various methods, among which L / M (lactulose / mannitol r...

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Abstract

The present invention relates to an application of arabinose and a composition for intestinal tract preparation. Specifically, the present invention provides the use of arabinose for preparing the composition. The composition is used for one or more uses selected from the group (i) used as a laxative; (ii) used for intestinal tract preparation; (iii) used for preventing and / or treating intestinalmucosal lesions; (iv) used for inhibiting an increase in intestinal mucosa permeability; (v) used for preventing and / or treating nausea; (vi) used for preventing and / or treating vomit; (vii) used forpreventing and / or treating abdominal pains; and / or (viii) used for preventing and / or treating side effects of oral magnesium sulfate.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the use of arabinose and a composition for bowel preparation. Background technique [0002] With the development of endoscopic technology, colonoscopy has been widely used clinically and has become one of the main means of diagnosis and treatment of various intestinal diseases. Colonoscopy is affected by bowel preparation to some extent. It is extremely important to make adequate bowel preparation before surgery to improve the image quality of colonoscopy to improve the detection rate of colonic diseases. [0003] Bowel preparation refers to a method such as oral cathartics or enemas to remove feces from the intestinal tract, reduce the number of intestinal bacteria and postoperative complications. Bowel preparation is widely used before bowel surgery, colonoscopy, enteroscopy, capsule endoscopy diagnosis and treatment, and imaging examination, and is the key to the success of colonosco...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7004A61K33/06A61P1/10A61P1/08A61P1/00A23L33/125A23L33/16
CPCA61K31/7004A61K33/06A61P1/10A61P1/08A61P1/00A23L33/125A23L33/16A23V2002/00A61K2300/00A23V2200/32A23V2250/602A23V2250/161
Inventor 石国良林卫军陈旭王羽娟蔡许斌萧舜之
Owner 唐传生物科技(厦门)有限公司
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