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Freezing balloon catheter with excellent biocompatibility

A biocompatible, balloon catheter technology, used in catheters, cooling surgical instruments, and parts of surgical instruments, etc., can solve the problems of cell tissue destruction, slow cooling rate at the pulmonary vein port, and inability to cure atrial fibrillation. The effect of improving hydrophilicity and improving protein adsorption resistance

Inactive Publication Date: 2020-12-18
浙江桐轩医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of this application is to provide a cryoballoon catheter with excellent biocompatibility, which has the advantages of fully fitting the balloon to the patient's pulmonary vein ostium and quickly discharging the gas refrigerant in the balloon, which solves the problem of existing cryoballoon catheters. When the balloon catheter is used, the shape and size of the patient's pulmonary vein ostium are generally different, so the balloon cannot be fully fitted to the patient's pulmonary vein ostium, so it is difficult to sufficiently cool down the part, which will lead to abnormalities in this part The discharged cells and tissues cannot be completely destroyed, so the therapeutic effect will be reduced, and the patient's atrial fibrillation cannot be completely cured. During ablation and cooling, the gasified liquid refrigerant discharges slowly from the balloon, which will cause serious harm to the patient. The cooling rate at the pulmonary vein ostium is slow, which will increase the treatment time and reduce the treatment efficiency

Method used

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  • Freezing balloon catheter with excellent biocompatibility
  • Freezing balloon catheter with excellent biocompatibility
  • Freezing balloon catheter with excellent biocompatibility

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] see Figure 1-3 , a cryoballoon catheter with excellent biocompatibility, including a catheter 1 and a rubber suction ball 9, the left side of the outer ring of the catheter 1 is sheathed with a balloon 2, and both the catheter 1 and the balloon 2 are made of PET material , the top of the right side of the catheter 1 is provided with an infusion channel 3, the liquid outlet of the infusion channel 3 is connected with the inner cavity of the balloon 2, the liquid inlet of the infusion channel 3 is connected with the liquid outlet of the refrigeration equipment, and the infusion channel 3 The liquid outlet is provided with a first baffle 14, a spring 16 is connected between the left side of the first baffle 14 and the top of the conduit 1, the bottom of the right side of the conduit 1 is provided with an exhaust passage 4, and the exhaust passage 4 The air inlet is connected with the inner cavity of the balloon 2, the outer diameter of the first blocking plate 14 is great...

Embodiment 2

[0057] A cryoballoon catheter with excellent biocompatibility. The difference from Example 1 is that the PET material has been modified, including the following raw materials in parts by weight: 5 parts of PET, 3 parts of polyethylene glycol, and 1 part of neutral amino acid , 2 parts of dodecyl dimethyl benzyl ammonium bromide (CAS No.: 7281-04-1); the polyethylene glycol is PEG-400, PEG-1000, PEG-400, PEG-1000 mass ratio The neutral amino acid is 1:2; the neutral amino acid is glycine and L-leucine, and the mass ratio of glycine and L-leucine is 4:1; it includes the following steps:

[0058] (1) PET passes through the low-temperature plasma processor, the operation steps are: connect the plasma device, set the plasma gas flow rate as: NH 3 3 sccm, O 2 2sccm, vacuum degree 20Pa, temperature 25℃, treatment 100s.

[0059] (2) Dissolve 3 parts of polyethylene glycol and 1 part of neutral amino acid in 10 parts of deionized water, stir evenly, put the PET material obtained in...

Embodiment 3

[0066] A cryoballoon catheter with excellent biocompatibility, the difference from Example 1 is that the PET material is modified, including the following raw materials in parts by weight: 5 parts of PET, 5 parts of polyethylene glycol, and 1 part of neutral amino acid , 2 parts of dodecyl dimethyl benzyl ammonium chloride (CAS No.: 139-07-1); the polyethylene glycol is PEG-400, PEG-1000, PEG-400, PEG-1000 mass ratio The neutral amino acid is 1:3; the neutral amino acid is glycine and L-leucine, and the mass ratio of glycine and L-leucine is 5:1; it includes the following steps:

[0067] (1) PET passes through the low-temperature plasma processor, the operation steps are: connect the plasma device, set the plasma gas flow rate as: NH 3 3 sccm, O 2 1sccm, vacuum degree 20Pa, temperature 25℃, treatment 100s.

[0068] (2) Dissolve 5 parts of polyethylene glycol and 1 part of neutral amino acid in 10 parts of deionized water, stir evenly, put the PET material obtained in step ...

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Abstract

The invention discloses a freezing balloon catheter with excellent biocompatibility. The freezing balloon catheter comprises a catheter body and a rubber suction ball, wherein a balloon sleeves the left side of the outer ring of the catheter body; an infusion channel is formed in the top of the right side of the catheter body; a liquid outlet of the infusion channel communicates with an inner cavity of the balloon; a first blocking piece is arranged at the liquid outlet of the infusion channel; a spring is connected between the left side of the first blocking piece and the top of the catheterbody; an exhaust channel is formed in the bottom of the right side of the catheter body; an air inlet of the exhaust channel communicates with the inner cavity of the balloon; a second blocking pieceis arranged at the air inlet of the exhaust channel; a spring is connected between the top of the second blocking piece and the left side of the inner wall of the exhaust channel; a fixing screw can drive a sliding piece to move left and right and drive a sliding sleeve to slide left and right; the sliding sleeve can drive a second rotating rod to rotate front and back through a first rotating shaft; and the second rotating rod can drive the balloon to be supported outwards or contracted inwards. In the abovementioned way, the shape and size of the balloon can be adjusted according to the shape and size of the pulmonary vein opening of a patient, and the balloon can be fully attached to the pulmonary vein opening of the patient.

Description

technical field [0001] The invention relates to the technical field of medical equipment, in particular to a cryoballoon catheter with excellent biocompatibility. Background technique [0002] Most atrial fibrillation is caused by abnormal discharge at the junction of the pulmonary vein and the left atrium or in the pulmonary vein. Therefore, electrical isolation of the pulmonary vein is an effective method for the treatment of atrial fibrillation. The treatment can be performed by cryoablation, that is, into the cryoballoon catheter. Liquid refrigerant (liquid nitrogen), and fit it to the patient's pulmonary veins, through the ablation and heat absorption of the refrigerant, cool down the abnormally discharged cells and tissues, and irreversibly destroy them, so as to achieve the electrical isolation of pulmonary veins effect and is effective in the treatment of atrial fibrillation. When the existing cryoballoon catheter is in use, the shape and size of the patient's pulmo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/06A61L29/16A61L29/14A61B18/02
CPCA61B18/02A61B2018/0022A61B2018/00351A61B2018/0212A61L29/06A61L29/14A61L29/16A61L2300/208A61L2300/214A61L2300/404A61L2300/42C08L87/005
Inventor 沈坤
Owner 浙江桐轩医疗科技有限公司
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