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Method for extracting neohesperidin from fresh raw citrus aurantium fruits

A technology for neohesperidin and orange fruit is applied in the field of extracting neohesperidin, which can solve the problems of solvent residue, strong production seasonality, and difficulty in preservation, so as to reduce oxidative deterioration and discoloration, improve the content of finished products, and prevent raw materials metamorphic effect

Pending Publication Date: 2020-12-25
JIANGXI HAIFU BIOENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This application mainly obtains neohesperidin through n-butanol extraction and ethanol treatment, but neohesperidin is insoluble in n-butanol, and the product yield is extremely low; n-butanol has a high boiling point, and there is serious solvent residue. Low; the purity and color of the final product are difficult to meet
[0024] Although there are many extraction and separation processes for neohesperidin mentioned above, there are more or less problems such as low product quality and high production cost.
When fresh bitter orange fruit is used as raw material for the extraction of neohesperidin, there is still a certain amount of enzyme associated with glycosides in the fresh fruit. It has the effect of enzymatic destruction; the production of raw materials has strong seasonality, generally between April and June every year, and it is not easy to store, and it needs to process a large amount of fresh fruits in a short time, which increases the difficulty of extraction

Method used

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  • Method for extracting neohesperidin from fresh raw citrus aurantium fruits

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] This embodiment includes the following steps:

[0090] (1) Broken. Get the fresh bitter orange fruit of 2000kg, be broken into the coarse powder that particle diameter is 5 mm with fresh fruit crusher;

[0091] (2) Antioxidant countercurrent extraction. Put the coarse powder into a countercurrent extraction tank, and extract it countercurrently in hot tap water added with an antioxidant protective agent; extraction temperature: 82°C; antioxidant protective agent (a mixture of vitamin C and ferrous sulfate, the mass ratio is 1.8:1) Addition amount: 22kg (1.1% of coarse powder); extraction time: 2.5h; water addition amount: 6000L. Squeeze and filter after extraction; combine the continuously flowing extracts to obtain 5300L countercurrent extracts; filter residues will be treated separately;

[0092] (3) Filtration and clarification. Cool the countercurrent extraction solution to 58°C through a plate heat exchanger, pass it through a disc centrifuge, and then filter t...

Embodiment 2

[0101] (1) Broken. Get 8000kg of fresh bitter orange fruit, and use the fresh fruit crusher to crush the coarse powder with a particle size of 6 mm.

[0102] (2) Antioxidant countercurrent extraction. Put the coarse powder into a countercurrent extraction tank, and extract it countercurrently in hot tap water added with an antioxidant protection agent; extraction temperature: 86°C; antioxidant protection agent (a mixture of vitamin C and ferrous sulfate, the mass ratio is 2.5:1) Addition amount: 96kg (1.2% of coarse powder); extraction time: 3.0h; water addition amount: 30000L. Squeeze and filter after extraction; combine the continuously flowing extracts to obtain 27000L countercurrent extracts, and filter residues will be treated separately;

[0103] (3) Filtration and clarification. Cool the countercurrent extraction solution to 62°C through a plate heat exchanger, pass it through a disc centrifuge, and then filter the centrifugation solution through a complete set of ce...

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Abstract

The present invention discloses a method for extracting neohesperidin from fresh raw citrus aurantium fruits. The method comprises the following steps: (1) crushing; (2) countercurrent extraction; (3)filtering and clarifying; (4) refining with a high-temperature organic membrane; (5) concentration and low-temperature salting-out; (6) hot melting, calcium salt precipitation, decolorization and filtration; (7) salt-assisted fractional crystallization; (8) desalting and filtering; and (9) drying. Purity of the obtained neohesperidin can reach 98.73% and color of the neohesperidin is pure white;the fresh raw citrus aurantium fruits are used as an extraction raw material, the corresponding efficient extraction technology is matched, the fresh raw material can be treated in batch in time, deterioration and mildewing of the raw material are avoided, large-scale production is achieved at the efficiency several times that of a traditional extraction tank extraction, the working efficiency isgreatly improved, a production cost is greatly reduced, only water is used as a solvent in the whole technological process, the production cost is reduced, and production safety and use safety of theproduct are also improved; and the method is simple, practical, safe, low in production cost, high in efficiency and short in period.

Description

technical field [0001] The invention relates to a method for extracting neohesperidin from bitter oranges, in particular to a method for extracting neohesperidin from fresh bitter oranges. Background technique [0002] Neohesperidin (Neohesperidin) is a dihydroflavonoid compound, white needle-like crystals (recrystallized from dilute ethanol or dilute acetic acid), melting point 236-237°C; easily soluble in hot water, soluble in hot ethanol, insoluble In ether; it turns brown when it encounters ferric chloride; it turns red when it is reduced by magnesium and hydrochloric acid; it does not precipitate when it is introduced into the alkali solution; Li sugar 1 molecule each. [0003] CAS number: 13241-33-3 [0004] Molecular formula: C 28 h 34 o 15 [0005] Molecular weight: 610.56 [0006] Structural formula: [0007] [0008] EINECS Number: 236-216-9 [0009] Neohesperidin has the effects of reducing phlegm and eliminating stagnation, dispelling qi and eliminati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H1/08C07H17/07
CPCC07H1/08C07H17/07
Inventor 刘庚贵黄华学何安乐黄俊
Owner JIANGXI HAIFU BIOENG