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Lecithin-lipid astaxanthin flexible nanoliposome and preparation method thereof

A nano-liposome and astaxanthin technology, which is applied in the field of medicine, can solve the problems of poor stability and low bioavailability of astaxanthin, and achieves improved reproductive capacity, high flexibility and hydrophilicity, and strong anti-oxidation. active effect

Inactive Publication Date: 2020-12-29
贵州鲑途生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a flexible nano-liposome of ovaline astaxanthin, which solves the problems of poor stability and low bioavailability of astaxanthin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] In this embodiment, a flexible nanoliposome of ovaline astaxanthin comprises the following raw materials in percentage by weight: egg yolk lecithin 20%, polydimethylsiloxane 2.0%, aminopolyethylene glycol phospholipid 5.0%, 2% camellia seed oil, 10.0% egg oil (containing 3.0% egg astaxanthin), and the rest is hydration solution (0.001 mol / L phosphate buffer).

[0024] The preparation method is as follows:

[0025] (1) Weigh quantitative phospholipid compounds, membrane softener, membrane stabilizer, system stabilizer and egg oil (containing 3.0% oval astaxanthin) and dissolve in an organic solvent, the organic solvent is methanol and chloroform (Volume ratio 4:1) mixed solution;

[0026] (2) After adding an appropriate amount of hydration solution, heat to 50 °C, start the high-pressure homogenizer for homogenization, maintain the pressure at 40 MPa, rotate at 8000 r / min, and homogenize for 20 min;

[0027] (3) Then add the hydration solution that has been preheated t...

Embodiment 2

[0029] In this embodiment, a flexible nanoliposome of ovaline astaxanthin comprises the following raw materials in percentage by weight: egg yolk lecithin 10%, soybean lecithin 10%, polydimethylsiloxane 4.0%, aminopolyethylene Diol phospholipids 8.0%, camellia seed oil 3%, egg oil (containing 3.0% egg astaxanthin) 20.0%, the rest is hydration solution.

[0030] The preparation method is as follows:

[0031] (1) Weigh quantitative phospholipid compounds, membrane softener, membrane stabilizer, system stabilizer and egg oil (containing 3.0% oval astaxanthin) and dissolve in an organic solvent, the organic solvent is methanol and chloroform (Volume ratio 4:1) mixed solution;

[0032] (2) After adding an appropriate amount of hydration solution, heat to 50 °C, start the high-pressure homogenizer for homogenization, maintain the pressure at 40 MPa, rotate at 8000 r / min, and homogenize for 40 min;

[0033] (3) Then add the hydration solution that has been preheated to 50°C, and re...

Embodiment 3

[0035] In this embodiment, a flexible nanoliposome of ovaline astaxanthin comprises the following raw materials in percentage by weight: soybean lecithin 10%, dipalmitoylcholine 15%, sodium glycocholate 4.0%, aminopolyethylene glycol Diol phospholipid 8.0%, camellia seed oil 5%, egg oil (containing 3.0% egg astaxanthin) 20.0%, and the rest is hydration solution.

[0036] The preparation method is as follows:

[0037] (1) Weigh quantitative phospholipid compounds, membrane softener, membrane stabilizer, system stabilizer and egg oil (containing 3.0% oval astaxanthin) and dissolve in an organic solvent, the organic solvent is methanol and chloroform (Volume ratio 4:1) mixed solution;

[0038] (2) After adding an appropriate amount of hydration solution, heat to 50 °C, start the high-pressure homogenizer for homogenization, maintain the pressure at 40 MPa, rotate at 8000 r / min, and homogenize for 60 min;

[0039] (3) Then add the hydration solution that has been preheated to 50...

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Abstract

The invention discloses lecithin-lipid astaxanthin flexible nanoliposome and a preparation method thereof. The flexible nanoliposome is coated with lecithin-lipid astaxanthin; and the lecithin-lipid astaxanthin is the state that haematococcus pluvialis is converted and enriched in the poultry represented by chicken to form components such as lecithin and lipid to cover astaxanthin in yolks. Through processing, micelle or liposome can be formed, better adsorption and utilization by human bodies can be realized, and the enhancement of stability can be achieved. The flexible nanoliposome includesphospholipid compounds, a membrane softening agent, a membrane stabilizer, a system stabilizer and egg oil (containing the lecithin-lipid astaxanthin).

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation formula and a preparation process of ovaline astaxanthin flexible nano-liposome. Background technique [0002] Astaxanthin is a carotenoid with strong antioxidant activity, 10 times higher than β-carotene, zeaxanthin and lutein, and 100 times higher than vitamin E. Astaxanthin can scavenge free radicals in the human body, weaken the damage of ROS and NMP to dermal collagen, thereby exerting a powerful anti-oxidation and anti-wrinkle effect; at the same time, astaxanthin has the ability to treat chronic inflammation, cardiovascular disease, diabetes, Metabolic syndrome, neurodegenerative diseases and anti-cancer effects. [0003] The accumulation of astaxanthin in Haematococcus pluvialis is as high as 5%, which is the best source of natural astaxanthin. Using the principle of bionics, add broken Haematococcus pluvialis to the feed of chickens, the asta...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/127A61K31/122A61K31/685A61K35/54A61K47/24A61K47/34A61K47/44A61P3/00A61P3/10A61P9/00A61P25/28A61P29/00A61P35/00A61K8/55A61K8/86A61K8/891A61K8/92A61Q19/00A23L33/10A23L33/115A23L29/00A23L29/30
CPCA61K9/127A61K47/24A61K47/34A61K47/44A61K31/122A61K31/685A61K35/54A61P29/00A61P9/00A61P3/10A61P3/00A61P25/28A61P35/00A61K8/553A61K8/891A61K8/86A61K8/922A61K8/925A61Q19/00A23L33/10A23L33/115A23L29/035A23L29/04A23L29/30A23V2002/00
Inventor 季家弘焦建刘智阳林健王立强
Owner 贵州鲑途生物科技有限公司
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