Preparation method of anesthetic

Abstract

The invention relates to the related technical field of anesthetics, and particularly discloses a preparation method of an anesthetic. The preparation method mainly comprises the following steps: (1)adding injection water with a temperature of 75-80 DEG C into a material mixing tank; (2) adjusting a target temperature of a thermostat to 25-30 DEG C, and pumping liquid nitrogen into an inlet section of a gas guide channel; (3) after the temperature is stabilized at the target temperature, weighing materials, adding sodium metabisulfite and disodium edetate into a feeding hopper, and then adding sodium acetate and acetic acid; and then adding articaine hydrochloride and sodium chloride, and dissolving the materials in the injection water; (4) adding medicinal charcoal into the feeding hopper, performing uniform stirring, stopping pumping liquid nitrogen, performing standing for 5-10 minutes, and performing circulating charcoal removal for 10-15 minutes; (5) preparing a 0.1 mol / L HCl solution, and dissolving weighed epinephrine into the prepared hydrochloric acid solution; and (6) adding the solution obtained in the step (5) into the material solution obtained in the step (4), continuously adding injection water, and performing filtering with a 0.22 [mu]m micro-porous filter element. The method can accelerate the cooling speed of the injection water.

Description

technical field [0001] The invention relates to the related field of anesthetic technology, in particular to a preparation method of anesthetic. Background technique [0002] Compound Articaine Hydrochloride Injection, a new type of amide-type oral anesthetic, commonly used specifications 1.7ml: articaine hydrochloride 68mg, epinephrine 17μg, the main components are 4% articaine hydrochloride and 1: 100,000 epinephrine is a small-volume injection. Its mechanism of action is that the main component articaine has a methyl lipid group, which has low fat solubility and high protein binding law, so it has good compatibility with anesthesia effect. The advantages are fast onset of anesthesia, strong tissue infiltration, and good anesthesia effect can be achieved only by submucosal infiltration anesthesia, thus simplifying the difficulty of operation, avoiding the disadvantages and adverse reactions of conduction block, and improving the reliability of anesthesia effect. It reduc...

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Problems solved by technology

[0014] In the above steps, since it is necessary to add water for injection at 75-80°C to the preparation container, after the temperature drops to 25°C, nitrogen filling and material addition are carried out. During this process, the cooling of the water needs to wait for a long time. thus making less efficient

In addition, the purpose of nitrogen filling is to carry out nitrogen protection during the process of adding materials and dissolving materials. In the above steps, nitrogen protection needs to seal the preparation container, and when adding materials, it is necessary to open the preparation container and stir the water for injection, and Since the density of nitrogen is lower than that of air, nitrogen is easy to float up, resulting in the contact of air with the solution, making the effect of nitrogen protection not good.

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