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Metronidazole vitamin B6 composition

A technology of vitamins and metronidazole, applied in the direction of inorganic non-active ingredients, antibacterial drugs, capsule delivery, etc., can solve the problems of slow dissolution rate, easy color change, easy moisture absorption, etc., and achieve fast dissolution speed and good taste masking Function, the effect of stable preparation quality

Active Publication Date: 2021-01-12
DISHA PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The stability test found that the metronidazole vitamin B6 pellets are easy to absorb moisture during storage, and are prone to discoloration during exposure under accelerated conditions, and agglomeration occurs between the pellets, and the dissolution rate slows down.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Prescription: metronidazole 2000g, vitamin B6 200g, sucrose starch ball core 480g, mannitol 370g, calcium silicate 60g, lactitol 180g, purified water 1000g.

[0032] Prepare 10000 capsules according to the preparation method described in the technical scheme of the instructions. The yield of the centrifugal granulation process was counted. Yield = weight of drug-containing pellets (g) / total amount of feed (g) * 100%. The data are shown in Table 1.

Embodiment 2

[0034] Prescription: metronidazole 2000g, vitamin B6 200g, sucrose starch ball core 680g, mannitol 680g, calcium silicate 160g, lactitol 450g, purified water 1000g.

[0035] Prepare 10000 capsules according to the preparation method described in the technical scheme of the instructions. The yield of the centrifugal granulation process was counted. Yield = weight of drug-containing pellets (g) / total amount of feed (g) * 100%. The data are shown in Table 1.

Embodiment 3

[0037] Prescription: metronidazole 2000g, vitamin B6 200g, sucrose starch ball core 480g, mannitol 450g, calcium silicate 90g, lactitol 270g, purified water 1000g.

[0038] Prepare 10000 capsules according to the preparation method described in the technical scheme of the instructions. The yield of the centrifugal granulation process was counted. Yield = weight of drug-containing pellets (g) / total amount of feed (g) * 100%. The data are shown in Table 1.

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Abstract

The invention relates to a metronidazole vitamin B6 medicated pellet and a preparation method thereof. The technical scheme of the invention is as follows: the metronidazole vitamin B6 medicated pellet contains metronidazole, vitamin B6, a sucrose starch pellet core, mannitol, a filling agent, a disintegrating agent and an adhesive, wherein the filling agent is selected from vitamins, the disintegrating agent is selected from calcium silicate, and the adhesive is selected from lactitol. The invention provides the metronidazole vitamin B6 medicated pellet with excellent performance.

Description

technical field [0001] The invention relates to a drug-containing pellet of metronidazole and vitamin B6 and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Pellets are dose-dispersed, spherical or spherical-like oral preparations with a diameter of 0.5-1.5 mm. A dose is composed of multiple dispersed units, and usually a dose is composed of dozens to hundreds of pellets. The pellet preparation can be widely distributed in the gastrointestinal tract after being taken. Due to the dispersion of the dose, the drug has a large dispersion surface area in the gastrointestinal tract, which increases the bioavailability of the drug and reduces or eliminates the stimulation of the gastrointestinal tract. The drug release behavior of the pellet preparation is the sum of the drug release behaviors of the individual pellets that make up a dose. The mistakes or defects in the preparation of individual pellets wi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/4164A61K31/4415A61K47/26A61K47/02A61P31/04
CPCA61K9/1623A61K9/1611A61K31/4164A61K31/4415A61P31/04A61K2300/00Y02A50/30
Inventor 张孟杨德斌胡月白镇亚
Owner DISHA PHARMA GRP