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Thermo-sensitive composite antibacterial hydrogel with good photothermal effects, and application method and applications of hydrogel

A technology of composite hydrogel and photothermal effect, which is applied in medical formula, medical science, bandages, etc., to achieve good therapeutic effect, good biocompatibility, and simple preparation process

Pending Publication Date: 2021-01-22
苏州康瑞健生物医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to solve various problems existing in existing photothermal materials, the present invention provides a temperature-sensitive composite antibacterial hydrogel with good photothermal effect and its use method and application

Method used

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  • Thermo-sensitive composite antibacterial hydrogel with good photothermal effects, and application method and applications of hydrogel
  • Thermo-sensitive composite antibacterial hydrogel with good photothermal effects, and application method and applications of hydrogel
  • Thermo-sensitive composite antibacterial hydrogel with good photothermal effects, and application method and applications of hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Preparation and naming of embodiment 1 hydroxypropyl chitin / tannic acid / ferric chloride HPCH / TA / Fe hydrogel

[0041] Thermosensitive hydroxypropyl chitin HPCH, tannic acid TA and ferric chloride hexahydrate FeCl 3 ·6H 2 O is dissolved in ultrapure water at a low temperature of 2-15°C, and a HPCH solution with a mass concentration of 3wt%, a TA solution of 0.375wt% and a FeCl of 0.8wt% are prepared 3 ·6H 2 O solution. Take 1g of HPCH solution and add 0.4g of TA solution at a low temperature of 2-15°C and quickly vortex to mix evenly, then quickly add 0.1g of FeCl 3 The solution is vortexed and mixed evenly at a low temperature of 2-15°C, then the concentration of HPCH in the mixed solution is 2wt%, the concentration of TA is 0.1wt%, and the concentration of FeCl 3 ·6H 2 O concentration 0.053wt%, FeCl 3 ·6H 2 The molar ratio of O to TA was 3.33. The solution has good fluidity at a low temperature of 2-15°C, and it can be injected and sprayed. When the temperature ...

Embodiment 2

[0046] The preparation of embodiment 2 hydroxypropyl chitin / tannic acid HPCH / TA hydrogel

[0047] The thermosensitive hydroxypropyl chitin HPCH and tannic acid TA were dissolved in ultrapure water at a low temperature of 2-15°C respectively, and a HPCH solution with a mass concentration of 3wt% and a TA solution with a mass concentration of 0.375wt% were prepared, as in the example 1 The difference is that ferric chloride hexahydrate FeCl is not added to the hydrogel precursor solution 3 ·6H 2 O, take 1g of HPCH solution and add 0.4g of TA solution at a low temperature of 2-15°C to quickly vortex and mix evenly, then quickly add 0.1g of ultrapure water at a low temperature of 2-14°C to vortex and mix evenly, the hydrogel of this composition is named 2%-0.1%-0. However, the hydrogel precursor solution without adding metal ions here forms a hydrogel at 37°C, and then cools down to 2-14°C and cannot become a solution again, does not have good fluidity, does not have reversible ...

Embodiment 3

[0048] Example 3 Thermosensitive injectability and light-to-heat conversion performance of hydroxypropyl chitin / tannic acid / ferric chloride HPCH / TA / Fe hydrogel

[0049] Inject the 2%-0.1%-3.33 hydrogel precursor solution prepared in Example 1 above into a 1 mL syringe equipped with a 26G needle at 2-10 °C, as figure 1 As shown in (a), the hydrogel precursor solution can be easily injected from a 26G needle, and various shapes and figures can be produced, indicating that the hydrogel has excellent injectability. Inject the hydrogel precursor solution into glass vials such as figure 1 As shown in (b1), the precursor solution is a flowable liquid at 4°C; figure 1 As shown in (b2), a gel is formed rapidly at 37°C, and this solution-gel transition behavior is reversible.

[0050] In order to study the photothermal conversion ability of hydrogel, an 808nm near-infrared laser (Keplin, Beijing) was used to irradiate the hydrogel as an example, and the temperature change was observed...

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Abstract

The invention provides thermo-sensitive composite antibacterial hydrogel with good photothermal effects, and an application method and applications of the hydrogel. The hydrogel includes a thermo-sensitive polymer solution A substrate which contains polyhydroxy and is in a liquid state under low temperature, a tannic acid aqueous solution and an iron, ruthenium or vanadium ion solution, wherein the polymer solution A substrate can be crosslinked spontaneously at 35-45 DEG C; and the hydrogel can be formed by mixing the polymer solution A substrate, the tannic acid aqueous solution and the iron, ruthenium or vanadium ion solution at low temperature and spraying or injecting the mixture in an established body position. The hydrogel is sensitive in temperature and good in liquidity at low temperature, can be injected or sprayed, and can be rapidly formed under body temperature. The hydrogel has photothermal effects; the temperature can be increased to more than 60 DEG C from 25 DEG C within a short time after light exposure; and one-time injection and multiple photothermal therapy can be achieved through repeated illumination. Tissue can also grow and be repaired through the photothermal effects; and antimicrobial effects can be enhanced while the temperature of the hydrogel is increased. The hydrogel is simple in application method, has good biocompatibility and biodegradability,and can slowly release an anti-bacterial agent and reduce scar formation. The hydrogel can be used to repair skin wounds.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a temperature-sensitive composite antibacterial hydrogel with good photothermal effect and its use method and application. Background technique [0002] Since near-infrared light (NIR) has good tissue penetration ability and low energy loss, it is harmless to human tissues, so it can effectively absorb near-infrared light and effectively convert it into heat. Biomaterials with photothermal effects It has broad application prospects in the field of photothermal therapy, such as in skin wound repair. However, the existing photothermal material system mainly includes noble metal nanoparticles such as Au, Ag, Pt, graphene, and carbon nanorods. These photothermal conversion efficiency is high, but the price is expensive, and the biocompatibility needs to be studied, which can be used for in vitro diagnosis. , but cannot be used in vivo. [0003] Polymer hydrogel is a ...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/008A61L26/009A61L26/0066A61L26/0095A61L2400/06A61L2300/102A61L2300/21A61L2300/412C08L5/08C08L3/04
Inventor 蒋序林马梦思
Owner 苏州康瑞健生物医疗科技有限公司
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