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Shape memory hydrogel with magnetic, optical and thermal multi-stimulus response, preparation method and shape memory mode thereof

A multiple stimuli response and hydrogel technology, applied in the field of shape memory and shape memory hydrogel, can solve the problems of lack of remote control ability, simple deformation method, single stimulus response, etc., and achieve good biocompatibility and shape Flexible deformation and good application prospects

Active Publication Date: 2021-01-22
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The present invention aims at the problems of existing shape memory hydrogel materials such as simple deformation mode, single stimulus response and lack of remote control ability, and provides a magnetic, optical, thermal Preparation method of multiple stimulus-responsive shape memory hydrogels by introducing Fe3O4 nanoparticles into hydrogels, utilizing light, heating and magnetic manipulation functions Make the hydrogel deform or travel in the magnetic field, and can fix the temporary shape and restore the original shape in the process, with strong manipulation ability

Method used

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  • Shape memory hydrogel with magnetic, optical and thermal multi-stimulus response, preparation method and shape memory mode thereof
  • Shape memory hydrogel with magnetic, optical and thermal multi-stimulus response, preparation method and shape memory mode thereof
  • Shape memory hydrogel with magnetic, optical and thermal multi-stimulus response, preparation method and shape memory mode thereof

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Embodiment 1

[0048] This embodiment provides a preparation method of magnetic, photothermal and multiple stimulus-responsive shape memory hydrogels and the application of the shape memory method, providing a non-contact shape memory behavior and its directional navigation delivery behavior, first The hydrogel was prepared by free radical polymerization, and then the non-contact shape memory behavior and its directional navigation and delivery behavior were realized under the synergistic effect of magnetism and photothermal. The specific steps are as follows:

[0049] (1) First add 2g gelatin to 10ml deionized water, then add 1g Fe 3 o 4 Nanoparticles, oscillating ultrasonically to fully disperse; then dissolve 1.5g N-(2-hydroxyethyl)acrylamide (HEAA), 0.045g polyethylene glycol diacrylate (PEGDA) and 0.015g ammonium persulfate (APS) Prepare a pre-polymerization solution in the above solution; inject the pre-polymerization solution into the mold and react at 25°C for 12 hours; after obtain...

Embodiment 2

[0057] (1) First add 2g gelatin to 10ml deionized water, then add 0.5g Fe 3 o 4 Nanoparticles, oscillating ultrasonically to fully disperse; then 1g acrylamide (AAm), 0.03g ethylene glycol diacrylate (DEGDA) and 0.01g potassium persulfate (KPS) were dissolved in the above solution to form a prepolymer solution; The pre-polymerization solution was injected into the mold and reacted at 60°C for 4 hours; after the hydrogel was obtained, it was cut and processed into the desired shape for future use. At this time, the shape fixation rate of the hydrogel was 93.6%.

[0058] One way to realize shape memory:

[0059] (2) Cut the hydrogel obtained in step (1) into a humanoid hydrogel and place it on a plane, fix the part below the waist, and use an energy density of 1W / cm 2 The near-infrared light irradiation for 30 s activates the Fe 3 o 4 The light-to-heat conversion ability of nanoparticles unwinds the triple helix of the gelatin segment, and at this time the modulus of the hyd...

Embodiment 3

[0065] (1) First add 2g gelatin to 10ml deionized water, then add 0.05g Fe 3 o 4 Nanoparticles, oscillating ultrasonically to fully disperse; then 1.5g hydroxyethyl methacrylate (HEMA), 0.045N, N'-methylenebisacrylamide (MBA) and 0.015g ammonium persulfate (APS) were dissolved in the above Prepare the pre-polymerization liquid in the solution; inject the pre-polymerization liquid into the mold and react at 40°C for 6 hours; after obtaining the hydrogel, cut it into the desired shape for later use. At this time, the shape fixation rate of the hydrogel is 90% .

[0066] One way to realize shape memory:

[0067] (2) Cut the hydrogel obtained in step (1) into a human-like hydrogel and place it on a plane, fix the part below the waist, and use an energy density of 1.5W / cm 2 The near-infrared light irradiation for 30 s activates the Fe 3 o 4 The light-to-heat conversion ability of nanoparticles unwinds the triple helix of the gelatin segment, and at this time the modulus of the...

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Abstract

The invention relates to a shape memory material, and discloses a shape memory hydrogel with magnetic and photo-thermal multi-stimulus responsive, a preparation method and a shape memory mode thereof,the preparation method is obtained by polymerizing gelatin, Fe3O4 nanoparticles, a monomer, a cross-linking agent and an initiator, and the shape memory mode is as follows: the hydrogel is in an original shape at a temperature lower than a gelatin conversion temperature; when the hydrogel is illuminated, a triple-helix structure of the gelatin is unscrewed into a single strand, the gel is deformed into any shape under the action of a magnetic field, and the gel is cooled to obtain a fixed temporary shape; and illumination is applied again to enable the gel to spontaneously recover to the original shape. Due to the existence of the Fe3O4 nanoparticles, the shape memory process can be realized by externally applying a magnetic field under a non-contact condition. Based on the fact that a non-contact shape memory mode and directional movement can be achieved, the hydrogel can be applied to preparation of controlled release preparations.

Description

technical field [0001] The invention relates to a shape memory material, in particular to a shape memory hydrogel responding to multiple stimuli of magnetism, light and heat, a preparation method and a shape memory method thereof. Background technique [0002] Shape memory polymers can change their shape and fix this "temporary shape", and when they are stimulated again by the outside world, they can reversibly restore the "original shape" before being deformed. Due to its many good properties, shape memory polymers can play a huge role in high-tech fields such as biomedicine, electronic devices, and aerospace. As a class of shape memory polymers, shape memory hydrogel materials have the characteristics of high water content, high permeability, softness and high biocompatibility. These properties are very close to the structure of human soft tissue. Therefore, shape memory hydrogel materials have unique advantages in the field of biomedicine, especially in the controlled r...

Claims

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Application Information

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IPC IPC(8): C08F289/00C08F283/06C08F220/58C08F220/56C08F222/14C08F220/20C08F222/38C08K3/22A61K41/00A61K9/06A61K47/02A61K47/42
CPCC08F289/00C08F283/065C08K3/22A61K41/00A61K9/06A61K47/02A61K47/42C08K2201/011C08K2003/2275C08F220/58C08F220/56C08F222/102C08F220/20C08F222/385
Inventor 陈涛张大川张佳玮
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI