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Infiltration-type medicine composite amnion and preparation method and use method of medicine composite amnion

A technology of compounding amniotic membrane and amniotic membrane, which is applied in the field of medicine, can solve problems such as fragile perforation, trauma to the ocular surface, etc., and achieve the effect of reducing metabolic circulation in the body, reducing pain, and reducing medical costs

Pending Publication Date: 2021-01-26
钛盾生物(南京)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the method of fixing the amniotic membrane in amniotomy in clinical application at present is mainly surgical suture, which will inevitably damage the ocular surface. Because the amniotic membrane is thin, it is easy to be broken and perforated. Therefore, multiple operations are often required to achieve the purpose of treatment.
[0004] The applicant's previous applications "CN201620957026.X, Amniotic Mirror", "CN201610740372.7, Amniotic Mirror and Its Preservation Method" have disclosed a device that can fix the amniotic membrane on the eyelid without surgery and a method of preserving the amniotic membrane, a Chinese invention The patent "201910427807.6, a composite dressing containing amniotic membrane or micro-droplet drug and its preparation method" and the Chinese invention patent "200610071377.1, drug amniotic membrane and its preparation method" disclose the method of compounding the drug on the amniotic membrane, but these two The methods have their own limitations, and cannot bring out the advantages of drug-combined amniotic membrane

Method used

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  • Infiltration-type medicine composite amnion and preparation method and use method of medicine composite amnion
  • Infiltration-type medicine composite amnion and preparation method and use method of medicine composite amnion

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1, an infiltrating drug compound amniotic membrane, the preparation method of this infiltrating drug compound amniotic membrane is as follows: Step A: take fresh amniotic membrane, the fresh amniotic membrane is a healthy pregnant woman who is negative for HbsAg, HIV, HBV, BCV and syphilis. The obtained placenta is stripped under aseptic conditions, and the villi are removed at the same time, and then the surface of the fresh amniotic membrane is cleaned, and the cleaning solution can be physiological saline. If sterilization is required, soak the fresh amniotic membrane in physiological saline containing gentamicin 40u / ml and amphotericin 2.5mg / L for 15 minutes after washing. Step B: Dehydrating the fresh amniotic membrane, soaking the fresh amniotic membrane in a dehydrating solution with more than 49.9% glycerol for at least 10 minutes. Step C: Put the dehydrated fresh amniotic membrane into the medicinal liquid, which is 5-fluorouracil standard (batch num...

Embodiment 2

[0033] Example 2: An infiltrating drug compound amniotic membrane. The preparation method of the infiltrating drug compound amniotic membrane is: Step A: take the freeze-dried amniotic membrane, cut the freeze-dried amniotic membrane, and then put the freeze-dried amniotic membrane into the medicinal solution Among them, the freeze-dried amniotic membrane is provided by Jiangxi Ruiji Medical Devices Co., Ltd. The amniotic membrane is sterilized by freeze-drying technology and cobalt 60 irradiation, and has no pathogens such as hepatitis B, hepatitis C, syphilis, and AIDS. The drug solution is 5-fluorouracil standard product (batch number: 08052897), 5-Fu injection (marked volume: 10mL; 0.25g, Shanghai Xudong Haipu Pharmaceutical Co., Ltd.), the freeze-dried amniotic membrane needs to be rewarmed before soaking, soaking time At least 3 minutes, preferably 3 minutes to 5 minutes. Step B: After the lyophilized amniotic membrane is rewarmed and recovered, the lyophilized amniotic ...

Embodiment 3

[0034] Embodiment 3: A kind of infiltrating type drug composite amniotic membrane, the preparation method of this infiltrating type drug composite amniotic membrane is: comprise: Step A: take fresh amniotic membrane, and fresh amniotic membrane is the healthy person that HbsAg, HIV, HBV, BCV and syphilis examination all are negative The placenta obtained by caesarean section of pregnant women is stripped under sterile conditions, and the villi are removed at the same time, and then the surface of the fresh amniotic membrane is cleaned. The cleaning solution can be saline. After cleaning, the fresh amniotic membrane is placed in and amphotericin 2.5mg / L saline for 15 minutes to sterilize. Step B: cross-linking the fresh amniotic membrane, the cross-linking adopts the ultraviolet-riboflavin cross-linking method. Let the 0.1% riboflavin preparation (0.1%; Sigma Aldrich Inc.St.Louis, MO) fully and fully soak the amniotic membrane tissue for 10min, and then irradiate the amniotic m...

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Abstract

The invention discloses an infiltration-type medicine composite amnion and a preparation method and a use method of the medicine composite amnion, and relates to the technical field of medicines. Thepreparation method comprises the following steps: step A, taking a fresh amnion, and cleaning the surface of the fresh amnion; step B, dehydrating the fresh amnion; step C, putting the dehydrated fresh amnion into liquid medicine; and step D, taking out the fresh amnion from the liquid medicine after the dehydrated fresh amnion is recovered. The composite amnion carries medicine, has a long-term uniform medicine slow-release function, can be implanted into a human body or attached to the surface of the human body, so that the composite amnion can replace part of surgical treatment, the pain ofa patient the medical treatment cost are reduced, and the composite amnion can also be used as one of treatment means during surgical treatment, or as a recovery means after surgical treatment, and the composite amnion is particularly suitable for ophthalmic diseases and skin diseases.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a medicine-combined amniotic membrane, a preparation process of the medicine-combined amniotic membrane and its application. Background technique [0002] The ocular surface includes conjunctival epithelium, corneal epithelium and tear film. Clinically, ocular surface diseases mainly refer to lesions of the cornea and conjunctiva, also known as ocular surface tear diseases. Severe ocular surface diseases can cause severe vision loss or loss, and ocular surface reconstruction surgery aims to restore visual function. For example, in the early stage of ocular burns, especially severe alkali burns on the ocular surface, if effective treatment cannot be implemented in the early stage, local activation of collagenase and neutral vector enzymes will lead to progressive dissolution of ocular surface tissue and even corneal perforation. [0003] The amniotic membrane is the part of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K47/46A61K31/513A61P27/02A61P17/00
CPCA61K9/7007A61K31/513A61K47/46A61P17/00A61P27/02
Inventor 张晨明李启民王仁贤
Owner 钛盾生物(南京)有限公司