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Method for preparing citrus hesperidin

A technology for hesperidin and citrus peel residue, which is applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of high degree of automation, large consumption of organic solvents, and high extraction rate, and can reduce the amount of consumption. , The effect of reducing thermal energy consumption and increasing extraction rate

Inactive Publication Date: 2021-02-12
哈工大机器人南昌智能制造研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a method for preparing citrus hesperidin, which has a high extraction rate, a small amount of extraction solvent, and a high degree of automation. Large consumption, high toxicity and side effects of organic solvents, difficulty in large-scale industrial production of citrus hesperidin, etc.

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0025]A method for preparing citrus hesperidin, the method comprising the following steps:

[0026]1) Pretreatment of citrus peel residue: fresh raw materials of citrus peel residue are cleaned with water, dried with hot air, temperature 55℃, drying time 10h, so that the moisture content of citrus peel residue is 8%; the dried citrus peel residue is crushed by a high-speed grinder, 40 mesh After sieving, the citrus peel residue powder is obtained. If the dry citrus peel residue is selected, it can be directly crushed and sieved;

[0027]2) Extraction: Weigh 2kg of citrus peel powder in step 1) into a container, add 20L of 70% ethanol aqueous solution, the mass-volume ratio of the two is 1:10kg / L, and then continue to add NaOH solution to the container to adjust The pH of the extract was 11, and the extract was extracted at 50°C for 4 hours, and filtered with a filter to obtain the citrus hesperidin extract;

[0028]3) Concentration at low temperature: Rotary evaporate the citrus hesperidin e...

Embodiment 2

[0033]A method for preparing citrus hesperidin, the method comprising the following steps:

[0034]1) Pretreatment of citrus peel residue: clean the fresh raw materials of citrus peel residue with clean water, dry with hot air, temperature 55℃, drying time 10h, make the citrus peel residue water content 8%, dry citrus peel residue is crushed by a high-speed grinder, 40 mesh After sieving, the citrus peel residue powder is obtained. If the dry citrus peel residue is selected, it can be directly crushed and sieved;

[0035]2) Ultrasonic countercurrent extraction: One end of the continuous ultrasonic extraction device is connected to the citrus peel powder storage tank and the extraction liquid collection tank, and the other end is connected to the residue collection tank and the ethanol aqueous solution storage tank. The raw citrus peel powder and the ethanol aqueous solution enter from opposite directions. Ultrasonic extraction device realizes continuous extraction.

[0036]Weigh 2 kg of citr...

Embodiment 3

[0042]A method for preparing citrus hesperidin, the method comprising the following steps:

[0043]1) Pretreatment of citrus peel residue: fresh raw materials of citrus peel residue are cleaned with water, dried with hot air, temperature 70℃, drying time 5h, so that the moisture content of citrus peel residue is 5%, dried citrus peel residue is crushed by a high-speed grinder, 40 mesh After sieving, the citrus peel residue powder is obtained. If the dry citrus peel residue is selected, it can be directly crushed and sieved;

[0044]2) Ultrasonic countercurrent extraction: One end of the continuous ultrasonic extraction device is connected to the citrus peel powder storage tank and the extraction liquid collection tank, and the other end is connected to the residue collection tank and the ethanol aqueous solution storage tank. The raw citrus peel powder and the ethanol aqueous solution enter from opposite directions. Ultrasonic extraction device realizes continuous extraction.

[0045]Weigh t...

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PUM

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Abstract

The invention discloses a method for preparing citrus hesperidin. The method comprises the following steps: (1) pretreating citrus peel pomace: cleaning, drying and crushing the citrus peel pomace; (2) ultrasonic extraction: adding the citrus peel residue powder into an ultrasonic extraction device, performing extracting with NaOH ethanol, and performing filtering to obtain a citrus hesperidin extracting solution; (3) low-temperature concentration: concentrating the citrus hesperidin extracting solution in a low-temperature concentration device to obtain a citrus hesperidin concentrated solution, and recovering ethanol; (4) separation and purification: adding an HCl solution into the citrus hesperidin concentrated solution to adjust the pH value, separating out crude citrus hesperidin, performing cleaning, and performing recrystallizing with ethanol; and (5) preparing a finished product, namely crystallizing and freeze-drying the citrus hesperidin, and removing the ethanol solvent to obtain high-quality hesperidin. According to the method, ultrasonic-assisted organic solvent extraction is adopted, so that the extraction rate of the citrus hesperidin is increased, the extraction time is shortened, the use amount of an extraction solvent is reduced, low-temperature concentration is adopted, and the heat energy consumption is reduced.

Description

Technical field[0001]The invention belongs to the field of natural product extraction, and particularly relates to a method for preparing citrus hesperidin.Background technique[0002]Citrus (Citrusreticulata Blanco), a subordinate plant of the Rutaceae family, has high medicinal value. Hesperidin is one of the main components in citrus flavonoids. The full name of hesperidin is hesperetin-7-O-newhesperidin. Its biological activity is high and it has a good antioxidant effect on heterocyclic amines. Substances, 1-methyl-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid and N-methyl-N-nitro-N-nitrosoguanidine can inhibit the mutagenicity Function; can inhibit the carcinogenic effects of ammonium nitrite, aflatoxin and other carcinogens, have a certain preventive effect on breast cancer, lung cancer and other tumors; have a preventive effect on gastric ulcers; inhibit Staphylococcus aureus, Salmonella, etc. Function; has antagonistic effect on certain poisons; in addition, it also has an...

Claims

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Application Information

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IPC IPC(8): C07H1/08C07H17/07
CPCC07H1/08C07H17/07
Inventor 刘兆宇赵亮彭丽
Owner 哈工大机器人南昌智能制造研究院
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