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Application of a photostimuli-responsive hollow mesoporous organosilicon spheres loaded with perfluorohexane

A perfluorohexane, hollow mesoporous technology, which can be used in preparations for in vivo experiments, nanotechnology for sensing, pharmaceutical formulations, etc., can solve the problems of complex preparation, less Xe contrast agent, and high price. Achieve the effect of good biocompatibility, good photothermal performance and high sensitivity

Active Publication Date: 2021-11-05
INNOVATION ACAD FOR PRECISION MEASUREMENT SCI & TECH CAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However these 129 Among the Xe contrast agents, the intelligent response type 129 Xe contrast agent is currently less reported, and the preparation is relatively complicated and expensive

Method used

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  • Application of a photostimuli-responsive hollow mesoporous organosilicon spheres loaded with perfluorohexane
  • Application of a photostimuli-responsive hollow mesoporous organosilicon spheres loaded with perfluorohexane
  • Application of a photostimuli-responsive hollow mesoporous organosilicon spheres loaded with perfluorohexane

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Experimental program
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Embodiment 1

[0023] 1. Preparation of hollow mesoporous organosilica spheres:

[0024] Stir 200g of 10wt% aqueous solution of cetyltrimethylammonium chloride and 0.8g of triethanolamine in a 95°C oil bath, then add 1mL of tetraethyl orthosilicate dropwise, and react for 1 hour, then add 0.5mL of A mixture of tetraethyl silicate and 1mL 1,4-bis(triethoxysilyl)propane tetrasulfide was added to the above-mentioned reacted solution, and the reaction was continued for 4h, and the resulting mixture was centrifuged at 3000rpm for 5min , the obtained solid was washed 3 times with ethanol to obtain an intermediate product; the intermediate product was dispersed in a mixed solution of 100 mL absolute ethanol and 10 mL concentrated hydrochloric acid, heated to 78 ° C for 12 h, and this operation was repeated 3 times to completely remove CTAC , to obtain MSNs (MSN@MON) coated with mesoporous organosilica, washed MSN@MON with ethanol several times, dispersed the obtained solid in 20mL water, added 8mL ...

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Abstract

The invention discloses the application of a hollow mesoporous organosilicon sphere loaded with perfluorohexane in response to light stimulation. The hollow mesoporous organosilicon sphere can passively target tumors through the high permeability and retention effect of solid tumors. perfluorohexane can guarantee 129 Xe MRI signal intensity, CuS nanoparticles attached to the surface of silicone spheres have photothermal conversion properties, near-infrared light stimulation can induce the phase transition of perfluorohexane, realize the detection of tumor cells, and at the same time realize the intelligent response 129 The transition of Xe MRI signal from "ON" to "OFF" avoids the appearance of false positive signal.

Description

technical field [0001] The invention belongs to the technical field of nuclear magnetic resonance imaging, and in particular relates to the application of a hollow mesoporous organic silicon sphere loaded with perfluorohexane in response to light stimulation. Background technique [0002] The early diagnosis of tumor is very important to its curative effect, and the use of appropriate diagnostic methods is also very important to the early diagnosis of tumor. Magnetic Resonance Imaging (MRI) is widely used in clinical diagnosis due to its high spatial resolution and non-invasiveness. However, due to its low sensitivity, it is usually necessary to use magnetic resonance contrast agents to enhance the contrast effect in clinical practice. At present, the contrast agent widely used in clinic is the complex of paramagnetic metal Gd, which can change the longitudinal relaxation time T1 of water to achieve contrast enhancement, but also because of its strong physiological toxicity,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/08A61K49/18B82Y5/00B82Y15/00
CPCA61K49/08A61K49/183B82Y5/00B82Y15/00
Inventor 周欣丘茂松陈世桢王瑞芳娄昕
Owner INNOVATION ACAD FOR PRECISION MEASUREMENT SCI & TECH CAS