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A high-strength shape-memory chitosan-based hydrogel and its preparation method and application

A chitosan and hydrogel technology, applied in the field of biomedical engineering materials, can solve the problems of lack of mechanical properties and shape memory properties, and achieve the effects of simple preparation and application process, improved mechanical properties, and wide application prospects.

Active Publication Date: 2022-02-25
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chitosan-based hydrogels currently lack mechanical properties and shape memory properties.

Method used

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  • A high-strength shape-memory chitosan-based hydrogel and its preparation method and application
  • A high-strength shape-memory chitosan-based hydrogel and its preparation method and application
  • A high-strength shape-memory chitosan-based hydrogel and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] At room temperature, taking 0.21g of chitosan with a degree of deacetylation of 90% was dissolved in 10g of 3wt% acetic acid solution, stirred on a magnetic stirrer at 25°C for 6h, then added 0.09g of citric acid, and continued to stir for 4 Hour, obtain chitosan solution, then add 0.05g dopamine hydrochloride to chitosan solution and continue to stir on magnetic stirrer 6h, the chitosan-based solution that forms is poured in the mold (get rid of air bubbles) and put into-20 ℃ freezer Freeze for 12 hours. After being taken out from the freezer, it was thawed with 0.5M sodium hydroxide solution for 6 hours, washed with distilled water until the pH was neutral after thawing completely, and freeze-dried to obtain a high-strength shape memory chitosan-based hydrogel. The morphology of the high-strength shape-memory chitosan-based hydrogel is shown in Fig. figure 1 As shown in B, according to figure 1 B shows that the high-strength shape-memory chitosan-based hydrogel has ...

Embodiment 2

[0028] At room temperature, taking 0.21g of chitosan with a degree of deacetylation of 90% was dissolved in 10g of 3wt% acetic acid solution, stirred on a magnetic stirrer at 25°C for 6h, then added 0.09g of citric acid, and continued to stir for 4 Hour, obtain chitosan solution, then add 0.007g graphene oxide in chitosan solution, continue to stir 6h on magnetic stirrer with ultrasonic cleaner ultrasonic 15min. The resulting chitosan-based solution was poured into a mold (to exclude air bubbles) and placed in a -20°C freezer for 12 hours. After being taken out from the freezer, it was thawed with 0.5M sodium hydroxide solution for 6 hours, washed with distilled water until the pH was neutral after thawing completely, and freeze-dried to obtain a high-strength shape memory chitosan-based hydrogel. The morphology of the high-strength shape-memory chitosan-based hydrogel is shown in Fig. figure 1 C, according to figure 1 C shows that the high-strength shape-memory chitosan-bas...

Embodiment 3

[0031] At room temperature, taking 0.21g of chitosan with a degree of deacetylation of 90% was dissolved in 10g of 3wt% acetic acid solution, stirred on a magnetic stirrer at 25°C for 6h, then added 0.09g of citric acid, and continued to stir for 4 Hour, obtain chitosan solution, then add 0.05g dopamine hydrochloride and 0.007g graphene oxide in chitosan solution, continue to stir 6h on magnetic stirrer with ultrasonic cleaner ultrasonic 15min. The resulting chitosan-based solution was poured into a mold (to exclude air bubbles) and placed in a -20°C freezer for 12 hours. After being taken out from the freezer, it was thawed with 0.5M sodium hydroxide solution for 6 hours, washed with distilled water until the pH was neutral after thawing completely, and freeze-dried to obtain a high-strength shape memory chitosan-based hydrogel. The morphology of the high-strength shape-memory chitosan-based hydrogel is shown in Fig. figure 1 C, according to figure 1 C shows that this high-...

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Abstract

The invention belongs to the field of biomedical engineering materials, and discloses a high-strength shape-memory chitosan-based hydrogel, a preparation method and application thereof. Dissolve chitosan in acetic acid / citric acid solution, then add one of dopamine hydrochloride, graphene oxide and dopamine hydrochloride / graphene oxide, then stir evenly, thaw with lye after freezing, and use deionized water to wash Freeze-drying after being neutralized to obtain a high-strength shape-memory chitosan-based hydrogel is simple and effective, and the operation is easy and the required time is relatively short. The high-strength shape-memory chitosan-based hydrogel has good mechanical properties, does not contain chemical components, and has a shape-memory function. The high-strength shape-memory chitosan-based hydrogel is fixed into a temporary shape by ethanol treatment, and then the temporary shape The hydrogel, which can be put into water, PBS solution or blood, can restore its original shape, and has a wide range of application prospects.

Description

technical field [0001] The invention belongs to the field of biomedical engineering materials, and relates to a high-strength shape-memory chitosan-based hydrogel and a preparation method and application thereof. Background technique [0002] Biodegradable hydrogels have a three-dimensional network structure similar to natural tissues, can quickly absorb water, have high water content and are insoluble, and have good biocompatibility. They have been widely used in various tissues and organs (such as bone, cartilage, skin, etc.) etc.) repair and regeneration. Chitosan is a biomacromolecule formed by deacetylation of chitin, mainly composed of glucosamine and N-acetylglucosamine connected by 1,4-β-glucosidic bonds. It is a commonly used bio-based functional material for the preparation of tissue engineering scaffolds due to its excellent capacity, biodegradability and antibacterial properties. At present, chitosan and its derivatives have been widely used in biomedical field...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/075C08L5/08C08K3/04C08K5/18A61L27/20A61L27/02A61L27/52A61L27/56
CPCC08J3/075A61L27/20A61L27/025A61L27/52A61L27/56C08J2305/08C08K3/042C08K5/18A61L2400/16C08L5/08
Inventor 袁卉华杜茜熊峰李碧云宣红云杨宇民
Owner NANTONG UNIVERSITY
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