A kind of crystal glue for hemostasis and carrying anticancer drugs and preparation method thereof

A technology of anticancer drugs and crystal gel, which is applied in drug delivery, pharmaceutical formulations, applications, etc., and can solve the problems of lack of hemostatic items and lack of inhibition

Active Publication Date: 2022-07-12
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to overcome the shortcomings of the above-mentioned prior art, and provide a crystal gel for hemostasis and carrying anticancer drugs and its preparation method, so as to solve the lack of hemostatic articles capable of inhibiting internal bleeding in the prior art, and the lack of anticancer drugs. The problem of transferring items with blood flow after surgery

Method used

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  • A kind of crystal glue for hemostasis and carrying anticancer drugs and preparation method thereof
  • A kind of crystal glue for hemostasis and carrying anticancer drugs and preparation method thereof
  • A kind of crystal glue for hemostasis and carrying anticancer drugs and preparation method thereof

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preparation example Construction

[0039] The invention discloses a crystal glue for hemostasis and carrying anticancer drugs, and the preparation method comprises the following steps:

[0040] (1) Synthesize complex A through a double bond functionalization reagent and a first biomacromolecule;

[0041] (2) Synthesize complex B through polyphenolic compounds and second biomacromolecules;

[0042] (3) Synthesis of nanoparticles C by anticancer substances, dopamine and ZIF-8;

[0043] (4) The crystal gel is prepared by compound A, compound B and nanoparticle C.

[0044] Preferably, in step 1, the first biomacromolecule is chitosan or its derivatives, gelatin or its derivatives, hyaluronic acid or its derivatives, alginate or its derivatives, dextran or its derivatives derivatives, cellulose or its derivatives, polyvinyl alcohol or its derivatives, polyethylene glycol or its derivatives, or Pluronic F127 or its derivatives; the first biological macromolecule is a or a combination of them;

[0045] The double ...

Embodiment 1

[0061] (1) Compound A, synthesis of quaternized chitosan (QCSG) modified with glycidyl methacrylate;

[0062] In step (1), the preparation steps of quaternized chitosan modified with glycidyl methacrylate include:

[0063] (1A) Suspend 1 g of chitosan in 36 mL of deionized water to obtain a suspension of chitosan;

[0064] (1B) Add 180 μL of glacial acetic acid to the chitosan suspension obtained in step (1A), and stir at 55° C. for 30 min;

[0065] (1C) The chitosan-glacial acetic acid solution obtained in step (1B) was added with GTMAC with a molar ratio of 2:1 to amino groups on the chitosan backbone under continuous stirring, and the reaction mixture was stirred at 55° C. for 15 hours;

[0066] (1D) After the reaction of step (1C) is completed, under continuous stirring at 55°C, GMA is added dropwise to the above reaction mixture, and the ratio of GMA to amino groups on the main chain of pure chitosan is fixed to 0.5:1.0, under dark conditions The reaction was carried ou...

Embodiment 2

[0087] Different from Example 1, in step (4A), QCSG, HA-DA and ZDH nanoparticles were prepared after 5 wt %, 1.5 wt % and 1 wt % aqueous solution or dispersion, respectively. 600 μL of QCSG aqueous solution was mixed with 100 μL of ZDH aqueous dispersion and 200 μL of HA-DA aqueous solution, pre-cooled in an ice bath, and the corresponding prepared crystal gel was named QH10 / ZDH.

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Abstract

The invention discloses a crystal gel for hemostasis and carrying anticancer drugs and a preparation method thereof. The preparation method firstly modifies double bonds on biological macromolecules, grafts polyphenolic compounds on biological macromolecules, and utilizes dopamine Molecules and Zn 2+ Ion coordination to prepare dopamine-modified ZIF‑8. Each component is prepared into an aqueous solution or dispersion, and then under the action of an initiator, a multifunctional water / blood-triggered shape memory gel is formed at low temperature through double bond polymerization. The present invention is based on biological macromolecules such as polysaccharides with good biocompatibility and degradation performance, and the process of chemically grafting double bonds or polyphenolic compounds also has the characteristics of low toxicity and no pollution. The double bond functionalization used in the present invention The biomacromolecule is simple to prepare, the synthesis technology is mature, and the prepared product has a good general type.

Description

【Technical field】 [0001] The invention belongs to the technical field of biomedical materials, and particularly relates to a crystal gel for hemostasis and carrying anticancer drugs and a preparation method thereof. 【Background technique】 [0002] During tumor treatment, surgical resection remains the preferred and most effective method for cancer treatment. However, bleeding is unavoidable during tumor resection, especially in the resection of vascular-rich tumors, such as liver cancer, which makes hemostasis particularly important. Although there are many reported or commercially available hemostatic agents, such as tissue adhesives, glutaraldehyde cross-linked hemostatic agents or gelatin hemostatic agents, which have high hemostatic effect on superficial bleeding wounds, there is still a lack of clinical practice for complex internal bleeding. an effective strategy. For example, the current clinical treatment of hemorrhage in malignant liver tumor resection is still do...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/04A61L24/08A61L24/10A61L24/00A61L26/00
CPCA61L24/0015A61L24/0036A61L24/0094A61L26/0095A61L26/0066A61L26/0085A61L2300/416A61L2400/04A61L2300/624A61L2300/602
Inventor 郭保林梁永平乔李鹏李勐黄颖
Owner XI AN JIAOTONG UNIV
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