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High-purity zinc citrate trihydrate for oral cavity antianaphylaxis and preparation method thereof

A citric acid trihydrate, anti-allergic technology, applied in the direction of carboxylate preparation, carboxylate preparation, carboxylate preparation, etc., can solve problems such as easy to be damp and agglomerated, reduce raw material supply speed, increase capital consumption, etc., achieve Convenient preparation, improved yield and purity, and increased work efficiency

Inactive Publication Date: 2021-03-09
NANTONG FEIYU FINE CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Thereby, zinc citrate trihydrate is subjected to people's general attention and concern day by day, yet various problems still exist in the high-purity zinc citrate trihydrate and preparation method thereof for oral cavity antiallergic on the market
[0003] At present, there are still some problems in the existing high-purity zinc citrate trihydrate and its preparation method for oral anti-allergy: it is easy to be damp and agglomerated during storage, and the quality problem of use will be affected after the agglomeration. At the same time, the traditional preparation process needs to purchase A large amount of zinc carbonate and citric acid reduce the supply speed of raw materials and increase capital consumption. For this reason, we propose a high-purity zinc citrate trihydrate for oral anti-allergy and its preparation method

Method used

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  • High-purity zinc citrate trihydrate for oral cavity antianaphylaxis and preparation method thereof

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Embodiment 1

[0034] The invention provides a technical solution: a high-purity zinc citrate trihydrate for oral anti-allergy, including the following raw materials in parts by weight: 960 parts of zinc carbonate, 0.02 parts of fluoride, 0.001 part of arsenic, 0.001 part of cadmium, lemon 750 parts of acid, 1500 parts of deionized water, 10 parts of catalyst, and 20 parts of additives.

[0035] In this embodiment, preferably, the catalyst is 4-tert-butyl-calix[4]arene.

[0036] In this embodiment, preferably, the auxiliary agent is 1-vinyl-3-butylimidazolium bromide.

Embodiment 2

[0038] The invention provides a technical solution: a high-purity zinc citrate trihydrate for oral anti-allergy, comprising the following raw materials in parts by weight: 1000 parts of zinc carbonate, 0.03 parts of fluoride, 0.003 parts of arsenic, 0.003 parts of cadmium, lemon 1000 parts of acid, 2000 parts of deionized water, 18 parts of catalyst, 40 parts of additives.

[0039] In this embodiment, preferably, the catalyst is 4-tert-butyl-calix[4]arene.

[0040] In this embodiment, preferably, the auxiliary agent is 1-vinyl-3-ethylimidazolium bromide.

Embodiment 3

[0042] The invention provides a technical solution: a high-purity zinc citrate trihydrate for oral anti-allergy, including the following raw materials in parts by weight: 98 parts of zinc carbonate, 0.025 parts of fluoride, 0.002 parts of arsenic, and 0.002 parts of cadmium , 850 parts of citric acid, 1700 parts of deionized water, 14 parts of catalyst, and 30 parts of additives.

[0043] In this embodiment, preferably, the catalyst is a crown ether compound, and the crown ether compound is 12-crown-4.

[0044] In this embodiment, preferably, the auxiliary agent is 1-vinyl-3-ethylimidazolium chloride.

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Abstract

The invention discloses high-purity zinc citrate trihydrate for oral cavity antianaphylaxis. The high-purity zinc citrate trihydrate is prepared from the following raw materials in parts by weight: 960-1000 parts of zinc carbonate, 0.02-0.03 part of fluoride, 0.001-0.003 part of arsenic, 0.001-0.003 part of cadmium, 750-1000 parts of citric acid, 1500-2000 parts of deionized water, 10-18 parts ofa catalyst and 20-40 parts of an auxiliary agent. The invention further discloses a preparation method of the high-purity citric acid trihydrate for oral cavity antianaphylaxis. By adding a small amount of fluoride, arsenic and cadmium into the raw materials, the prepared high-purity zinc citrate trihydrate is more suitable for storage and is not influenced by caking, and meanwhile, a catalyst andan auxiliary agent can be added for catalyzing, so that the reaction process is accelerated, and the yield and the purity are improved.

Description

technical field [0001] The invention belongs to the technical field of zinc citrate hydrate, and in particular relates to a high-purity zinc citrate trihydrate for oral antiallergy and a preparation method thereof. Background technique [0002] Zinc is one of the trace elements needed by the human body. Zinc deficiency in the human body can lead to serious problems such as growth retardation and poor wound healing. The existing zinc supplements mainly include zinc sulfate, zinc acetate, and zinc gluconate. In addition, zinc citrate is also a very commonly used organic zinc supplement, which has the advantages of less irritation to the stomach and high zinc content, and can effectively enhance the digestion and absorption function of the human body. Zinc citrate generally contains two crystal waters, and reports on the preparation process of dihydrate are common in the prior art. Compared with zinc citrate dihydrate, zinc citrate trihydrate [(C6H5O7) 2Zn3 3H2O] has more exce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/41C07C51/02C07C51/42C07C51/43C07C51/50C07C59/265A23K10/30A23K10/12A61P1/02A61P37/08C12P7/48C01G9/00
CPCA23K10/12A23K10/30A61P1/02A61P37/08C01G9/00C07C51/02C07C51/412C07C51/42C07C51/43C07C51/50C07C59/265C12P7/48Y02P20/141
Inventor 姚建飞刘金库
Owner NANTONG FEIYU FINE CHEM