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Gold nanocluster with multiple optical signal channels

A technology of gold nanoclusters and optical signals, applied in the field of gold nanoclusters, can solve the problems of not being able to detect heavy metal ions at the same time and not have fluorescence characteristics, achieve good chemiluminescence characteristics and fluorescence characteristics, and improve real-time and convenience , cheap effect

Active Publication Date: 2021-03-09
WUHAN TEXTILE UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In the prior art, the particle size of luminol-modified gold nanomaterials (CN102191034A, CN101900723A, CN102021226A, CN104371705A, etc.) is greater than or equal to 10 nm. The gold nanomaterials have chemiluminescent properties due to the modification of luminol, but do not have fluorescent properties. It is applied to pesticide detection, immune analysis such as antibody, antigen or protein detection and nucleic acid detection such as DNA, RNA, aptamer molecules, and not for heavy metal detection
[0007] In addition, there are gold nanoclusters used to detect heavy metals in the prior art, but generally only one signal of fluorescence or chemiluminescence can be used to detect a single metal ion, and more than two different types of heavy metal ions cannot be detected at the same time. There is an urgent need for a single detection reagent that can detect a variety of heavy metal ions, so as to make up for the defect that a variety of different detection reagents need to be replaced in actual detection applications, and improve real-time and convenience

Method used

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  • Gold nanocluster with multiple optical signal channels
  • Gold nanocluster with multiple optical signal channels
  • Gold nanocluster with multiple optical signal channels

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1. Synthesis of gold nanocluster AuNCs with chemiluminescent and fluorescent multi-optical signaling channels.

[0044] Reagent sources: chloroauric acid, acetonitrile, heavy metal ions and hydrogen peroxide were purchased from Shanghai Reagent Company, luminol was purchased from TCI Reagent Company, and 11-mercaptoundecanoic acid (MUA) was purchased from Anaiji Reagent Company.

[0045] The AuNCs were prepared by dissolving 0.0131 g of 11-mercaptoundecanoic acid (MUA) in 18 mL of ultrapure water containing NaOH, then adding 10 mM 1.5 mL of chloroauric acid solution, and then adding NaOH solution dropwise so that The originally cloudy solution became clear. After the solution was stirred for 20 minutes, 0.9 mL of 10 mM luminol solution was added dropwise, and the mixture was heated and stirred at 60° C. for 8 hours. Finally, excess reactants were added into acetonitrile (mixed with nanomaterials in a volume ratio of 2:1) and centrifuged (12000 rpm). The prepar...

Embodiment 2

[0047] Example 2. Synthesis of gold nanocluster AuNCs with chemiluminescent and fluorescent multi-optical signaling channels.

[0048] The AuNCs were prepared by dissolving 0.0131 g of 11-mercaptoundecanoic acid (MUA) in 18 mL of ultrapure water containing NaOH, then adding 10 mM 1.5 mL of chloroauric acid solution, and then adding NaOH solution dropwise so that The originally cloudy solution became clear. After the solution was stirred for 20 minutes, 0.9 mL of 10 mM luminol solution was added dropwise, and the mixture was heated and stirred at 100° C. for 5.5 hours. Finally, excess reactants were added into acetonitrile (mixed with nanomaterials in a volume ratio of 2:1) and centrifuged (12000 rpm). The prepared AuNCs were redispersed in water and stored at 4 °C for use.

Embodiment 3

[0049] Example 3. Synthesis of gold nanocluster AuNCs with chemiluminescent and fluorescent multi-optical signaling channels.

[0050] The AuNCs were prepared by dissolving 0.0131 g of 11-mercaptoundecanoic acid (MUA) in 18 mL of ultrapure water containing NaOH, then adding 10 mM 1.5 mL of chloroauric acid solution, and then adding NaOH solution dropwise so that The originally cloudy solution became clear. After the solution was stirred for 20 minutes, 0.9 mL of 10 mM luminol solution was added dropwise, and the mixture was heated and stirred at 80° C. for 24 hours. Finally, excess reactants were added into acetonitrile (mixed with nanomaterials in a volume ratio of 2:1) and centrifuged (12000 rpm). The prepared AuNCs were redispersed in water and stored at 4 °C for use.

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Abstract

The invention discloses a gold nanocluster with multiple optical signal channels, belongs to the technical field of functionalized nano material detection, and relates to a gold nanocluster for selectively distinguishing and detecting multiple optical signals of multiple heavy metal ions. Undecylmercaptoundecanoic acid is used as an end-capping reagent and luminol is used as a reducing agent, thegold nanocluster is prepared by reducing chloroauric acid, and luminol and undecylmercaptoundecanoic acid are connected to the surface of the gold nanocluster. The gold nanocluster synthesized by themethod is uniform in size and has good chemiluminescence characteristics and fluorescence characteristics, and the method has the advantages of being simple, rapid and low in cost. The gold nanocluster can be used for selectively distinguishing various heavy metal ions. The gold nanocluster with the multiple optical signal channels has a wide application prospect in the fields of biological analysis and biological imaging.

Description

technical field [0001] The invention relates to the field of gold nanoclusters, in particular to a gold nanocluster with multiple optical signal channels, its preparation method and its application in selective detection of heavy metal ions. Background technique [0002] Metal nanoclusters with luminescent properties, such as gold and silver nanoclusters, are close in size to the Fermi wavelength of electrons, so they can exhibit characteristics similar to discrete electronic states of molecules. Ultrafine gold nanoclusters are composed of several gold atoms, and have size-related phosphorescence and fluorescence properties. Due to their good photostability and biocompatibility, gold nanoclusters with luminescent properties have become popular in recent years. It has been deeply applied to in vivo and in vitro imaging, metal ion sensing, and the construction of biosensors. In the past few decades, many methods have been developed to synthesize gold nanoclusters. For example...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/76G01N21/64B82Y40/00B82Y30/00
CPCG01N21/76G01N21/6402G01N21/6428B82Y40/00B82Y30/00
Inventor 高凌峰李伟何池洋桂云云杨雅雯
Owner WUHAN TEXTILE UNIV
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