Novel targeted lysosome ruthenium photocatalyst as well as preparation method and application thereof
A technology of photocatalysts and lysosomes, applied in the field of medicine, can solve problems such as the decline in the quality of life of patients and achieve high curative effect
Active Publication Date: 2021-03-12
SUN YAT SEN UNIV
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Abstract
The invention relates to the field of medicine, in particular to a novel targeted lysosome ruthenium photocatalyst as well as a preparation method and application thereof. The novel targeted lysosomeruthenium photocatalyst has a high curative effect when applied to photodynamic therapy of liver cancer (HepG2 cells), can target lysosome in cells, has a photocatalytic oxidation effect on NADH and amino acid, is of great significance to research of efficient and low-toxicity ruthenium complex photosensitizers, and lays experimental and theoretical foundations for clinical development of novel metal antitumor drugs. The metal ruthenium (II) complex has no toxicity (IC50>100 [mu] M) to human liver cancer cell strains in the absence of illumination, but has very strong growth inhibition ability(IC50 = 0.51 [mu] M) to the human liver cancer cell strains under illumination, can target lysosome, and has photocatalytic oxidation ability to NADH in cancer cells.
Application Domain
Ruthenium organic compoundsPhotodynamic therapy +2
Technology Topic
PhotosensPhoto catalysis +13
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