Wound hemostasis and repair product based on hyaluronic acid and preparation method of product

A technology of hyaluronic acid and products, which is applied in the field of wound hemostatic repair products and its preparation, can solve the problems of easy shedding and displacement, low bonding fastness, etc., and achieve the effect of not easy displacement, increased strength, and increased strength

Active Publication Date: 2021-03-16
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the problems of low bonding fastness between the gel material and the base, easy falling off and displacement, etc., the present invention provides a hyaluronic acid-based wound hemostatic repair product, which improves the structure of the base and improves the coagulation rate. Bonding fastness between glue and substrate

Method used

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  • Wound hemostasis and repair product based on hyaluronic acid and preparation method of product
  • Wound hemostasis and repair product based on hyaluronic acid and preparation method of product
  • Wound hemostasis and repair product based on hyaluronic acid and preparation method of product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Step 1: Prepare materials;

[0044] Step 2: Take the substrate, soak it in ethanol for 20 minutes, ultrasonically clean it, then wash it with deionized water, and dry it; take Tris-HCl buffer and dopamine to prepare a dopamine buffer solution, and place the dried substrate in the dopamine buffer solution In the process, react in a constant temperature water bath at 25°C for 24 hours, wash with deionized water, and dry to obtain a pretreated substrate with a polydopamine layer on the upper surface; wherein the thickness of the polydopamine layer is 40nm, and the substrate is non-woven fabric;

[0045] Step 3: Place the pretreated substrate in a magnetron sputtering vacuum chamber, vacuumize and carry out magnetron sputtering coating under the protection of argon gas, first coat a layer of titanium on the surface of the polydopamine layer of the pretreated substrate, and then A layer of silver is coated on the surface of the titanium layer to obtain a modified substrate (...

Embodiment 2

[0051] Step 1: Prepare materials;

[0052] Step 2: Take the substrate, soak it in ethanol for 25 minutes, ultrasonically clean it, then wash it with deionized water, and dry it; take Tris-HCl buffer and dopamine to prepare a dopamine buffer solution, and place the dried substrate in the dopamine buffer solution In the process, react in a constant temperature water bath at 27°C for 26 hours, wash with deionized water, and dry to obtain a pretreated substrate with a polydopamine layer on the upper surface; wherein the substrate is a non-woven fabric, and the thickness of the polydopamine layer is 43nm;

[0053] Step 3: Place the pretreated substrate in a magnetron sputtering vacuum chamber, vacuumize and carry out magnetron sputtering coating under the protection of argon gas, first coat a layer of titanium on the surface of the polydopamine layer of the pretreated substrate, and then A silver layer is coated on the surface of the titanium layer to obtain a modified substrate; t...

Embodiment 3

[0059] Step 1: Prepare materials;

[0060] Step 2: Take the substrate, soak it in ethanol for 30 minutes, ultrasonically clean it, then wash it with deionized water, and dry it; take Tris-HCl buffer and dopamine to prepare a dopamine buffer solution, and place the dried substrate in the dopamine buffer solution In the process, react in a constant temperature water bath at 28°C for 28 hours, wash with deionized water, and dry to obtain a pretreated substrate with a polydopamine layer on the upper surface; wherein the substrate is a non-woven fabric, and the thickness of the polydopamine layer is 45nm;

[0061] Step 3: Place the pretreated substrate in a magnetron sputtering vacuum chamber, vacuumize and carry out magnetron sputtering coating under the protection of argon gas, first coat a layer of titanium on the surface of the polydopamine layer of the pretreated substrate, and then A silver layer is coated on the surface of the titanium layer to obtain a modified substrate; t...

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Abstract

The invention discloses a wound hemostasis and repair product based on hyaluronic acid and a preparation method of the product.The wound hemostasis and repair product comprises a substrate and activegel located on the substrate, the substrate is a composite substrate, the composite substrate sequentially comprises a base material, a polydopamine layer, a titanium layer and a silver layer from bottom to top, a plurality of grooves are formed in the composite substrate, and the grooves are opened in the silver layer and reach the polydopamine layer in depth; and the active gel is based on hyaluronic acid, and the active gel based on hyaluronic acid is filled in the grooves and loaded on the upper surface of the whole composite substrate. The product of the invention has excellent antibacterial performance, can promote wound repair, inhibit wound bleeding, and can be effectively attached to wound skin in use by improving the structure of the composite substrate layer, at the same time, the wound dressing is not prone to deformation, gel slipping, etc., and the product is high in practicability.

Description

technical field [0001] The invention relates to a hyaluronic acid-based wound hemostatic repair product and a preparation method thereof, in particular to a hyaluronic acid-based wound hemostatic repair product with multiple functions such as hemostasis, repair, and antibacterial, and a preparation method thereof, belonging to medical use Technical field of gel products. Background technique [0002] Wound healing refers to a series of pathophysiological processes in which local tissues are repaired through regeneration, repair, and reconstruction after tissue loss due to the action of injury factors. In essence, it is an inherent defensive adaptive response of the body to tissue cell damage caused by various harmful factors; this regenerative repair is manifested in the recovery of lost tissue structure, and can also restore its function to varying degrees. [0003] Traditional wound repair materials such as gauze, animal fur, cotton, etc. are still used today because of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/26A61L15/18A61L15/28A61L15/40A61L15/42
CPCA61L15/26A61L15/18A61L15/28A61L15/40A61L15/42A61L2300/104A61L2300/102A61L2300/30A61L2300/404A61L2300/412A61L2300/45A61L2400/04C08L79/02C08L5/08
Inventor 钱林艺郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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