Ordered porous composite material as well as preparation method and application thereof

A porous composite material and reaction technology, applied in the direction of additive processing, pharmaceutical formulations, prostheses, etc., can solve the problems of long degradation cycle, low biological activity, low mechanical strength and potential immunogenicity, and achieve the effect of accurate simulation

Pending Publication Date: 2021-03-26
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing synthetic polymer materials have the disadvantages of long degradation cycle and low biological activity.
However, natural polymer materials face problems such as rapid degradation, low mechanical strength and potential immunogenicity.

Method used

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  • Ordered porous composite material as well as preparation method and application thereof
  • Ordered porous composite material as well as preparation method and application thereof
  • Ordered porous composite material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0082] This embodiment provides an ordered porous composite material, including photosensitive silk fibroin and borosilicate bioactive glass dispersed in the photosensitive silk fibroin. Based on the weight of the ordered porous composite scaffold as 100%, the weight of the borosilicate bioactive glass is 1%.

[0083] Wherein, borosilicate bioactive glass has the following composition:

[0084] 14SrO 8CaO 8MgO 38B 2 o 3 ·2P2 o 5 ·30SiO2 2 .

[0085] The particle size range of the borosilicate bioactive glass is 100-300nm.

[0086] The borosilicate bioactive glass also includes ZnO, and the molar content of ZnO is 1%.

[0087] The pore size of the ordered porous composite material is 50-300 μm; the pore density is 50-300 ppi.

Embodiment 2

[0089] This embodiment provides an ordered porous composite material. The difference from Example 1 is that, based on the weight of the ordered porous composite support as 100%, the micro-nano borosilicate bioactive glass 3% by weight.

[0090] Among them, the micro-nano borosilicate bioactive glass has the following composition:

[0091] 10SrO 10CaO 10MgO 38B 2 o 3 ·2P 2 o 5 ·30SiO2 2 ,

[0092] The particle size range of the bioactive glass is 30-100nm.

[0093] The borosilicate bioactive glass also includes Ag 2 O, Ag 2 The molar content of O is 0.25%.

[0094] The pore size of the ordered porous composite material is 200-300 μm; the pore density is 200-300ppi.

Embodiment 3

[0096] This embodiment provides an ordered porous composite material. The difference from Example 1 is that, based on the weight of the ordered porous composite support as 100%, the micro-nano borosilicate bioactive glass 5% by weight.

[0097] Among them, the micro-nano borosilicate bioactive glass has the following composition:

[0098] 20CaO 8MgO 27B 2 o 3 ·4P 2 o 5 41SiO2 2 ,

[0099] The particle size range of the bioactive glass is 50-250nm.

[0100] The borosilicate bioactive glass also includes Ag 2 O, CuO, Ag 2 The molar content of O was 0.2%, and the molar content of CuO was 0.3%.

[0101] The pore size of the ordered porous composite material is 100-200 μm; the pore density is 100-200 ppi.

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Abstract

The invention provides an ordered porous composite material as well as a preparation method and application thereof. The ordered porous composite material comprises borosilicate bioactive glass and photosensitive silk fibroin; the composite material has a photosensitive characteristic, and can be quickly cross-linked and solidified under ultraviolet irradiation; the composite material also has good mechanical properties, controllable degradation speed and high bone induction activity, and can be used as a composite artificial bone for bone and alveolar bone repair and treatment integration; and vascularization can be effectively induced, and new bone ingrowth and formation can be rapidly induced in situ, so that a good effect is achieved in the aspect of promoting bone regeneration. According to the preparation method of the ordered porous composite material, the simpleness is achieved, the operation is easy, the formation can be achieved at room temperature, and the application is convenient.

Description

technical field [0001] The invention belongs to the technical field of biological materials, and in particular relates to an ordered porous composite material and its preparation method and application. Background technique [0002] Chronic periodontitis and aging both predispose to progressive bone loss. Progressive bone loss can lead to tooth movement and dislocation, and eventually even tooth loss, which reduces the patient's quality of life. Therefore, the in situ regeneration of alveolar bone has attracted the attention of scholars. [0003] The natural bone matrix is ​​composed of type I collagen and nano-hydroxyapatite. Based on the organic-inorganic composite properties of natural bone matrix, bone powder is usually implanted clinically to guide tissue regeneration and achieve alveolar bone regeneration in situ. Among them, autologous bone transplantation is the gold standard. Although good results can be obtained, there will be secondary trauma, and the donor sit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/10A61L27/22A61L27/50A61L27/54B33Y70/10B33Y80/00
CPCA61L27/56A61L27/10A61L27/227A61L27/50A61L27/54B33Y70/10B33Y80/00A61L2430/02A61L2430/12A61L2300/104A61L2300/102A61L2300/412A61L2400/12C08L89/00
Inventor 潘浩波崔旭吕维加程德林
Owner SHENZHEN INST OF ADVANCED TECH
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