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Formaldehyde fluorescence sensor based on dansyl chloride as well as preparation method and application thereof

A fluorescence sensor, dansyl chloride technology, applied in the field of biochemistry, can solve the problems of low sensitivity, invasive destruction of biological tissues, etc., and achieve the effects of high sensitivity, good photostability, and great application prospects

Active Publication Date: 2021-04-02
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Common methods for determining formaldehyde content include spectrophotometry, electrochemical detection, gas chromatography, liquid chromatography, and sensor methods, but most of them have low sensitivity, and some require invasive destruction of biological tissues

Method used

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  • Formaldehyde fluorescence sensor based on dansyl chloride as well as preparation method and application thereof
  • Formaldehyde fluorescence sensor based on dansyl chloride as well as preparation method and application thereof
  • Formaldehyde fluorescence sensor based on dansyl chloride as well as preparation method and application thereof

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Embodiment

[0033] (1) a kind of preparation method of the formaldehyde fluorescent sensor based on dansyl chloride of the present invention is as follows:

[0034] (1.1) Synthesis of the first compound:

[0035] Dissolve p-hydroxybenzaldehyde (122mg, 1.0mmol) and triethylamine (304mg, 3.0mmol, catalyst) in CH 2 Cl 2 (15mL) was cooled to 0°C, then 5mL was added dropwise under nitrogen to dissolve in CH 2 Cl 2 Dansyl chloride (269mg, 1.0mmol) solution in . The mixture was stirred at 0 °C for 30 min, then the reaction mixture was warmed to room temperature, stirred for 3 h, and the reaction was complete by TLC. The reaction mixture was poured into 100 mL H 2 O, with each 50mL CH 2 Cl 2 Extract 3 times. The organic layer was washed with 50 mL brine, and the 2 SO 4 Dry, filter and concentrate. The crude product was purified by silica gel column chromatography to obtain the first compound.

[0036] (1.2) Synthesis of the second compound:

[0037] Dissolve 220 mg of allyl potassium...

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Abstract

The invention discloses a formaldehyde fluorescence sensor based on dansyl chloride as well as a preparation method and application of the formaldehyde fluorescence sensor. According to the method, the formaldehyde fluorescence sensor is synthesized by taking dansyl chloride as a precursor. The formaldehyde fluorescence sensor can selectively recognize formaldehyde in a water phase; and an ultraviolet-visible spectrophotometer and a fluorescence spectrophotometer are used for measuring the intensity change of a characteristic peak of the formaldehyde fluorescence sensor in a water phase, and the existence of formaldehyde is detected. The invention provides application of the target product in formaldehyde detection, and finds that the target product has a good formaldehyde detection effect. Compared with the prior art, the used raw materials are low in price, the synthesis steps are simple, the post-treatment is convenient, the large-scale production is easier to realize, and the formaldehyde fluorescence sensor has a great application prospect in the aspect of formaldehyde detection.

Description

technical field [0001] The invention belongs to the technical field of biochemistry, and in particular relates to a formaldehyde fluorescence sensor based on dansyl chloride and its preparation method and application. Background technique [0002] Formaldehyde is a common modern industrial product, but also a volatile chemical pollutant and a carcinogen. Exposure to exogenous formaldehyde is mostly through inhalation or ingestion. Endogenous formaldehyde is produced through a physiological process mediated by an enzyme system. For example, amine oxidase (SSAO), which is sensitive to semicarbazide, can generate formaldehyde, while the body’s There is also a corresponding molecular mechanism to get rid of formaldehyde. In a healthy human brain, the content of formaldehyde is 0.2-0.4mM. A moderate amount of formaldehyde plays an important role in human memory storage, retention and long-term memory retrieval. However, excessive formaldehyde can damage the central nervous syst...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C309/76C09K11/06G01N21/33G01N21/64
CPCC07C309/76C09K11/06G01N21/643G01N21/33C09K2211/1011C09K2211/1007
Inventor 邓盛元严旻川吴江南马科锋李力森黄亚齐
Owner NANJING UNIV OF SCI & TECH
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