Cefotiam bulk drug

Abstract

The invention discloses a cefotiam bulk drug, and relates to the technical field of drug preparation. The cefotiam bulk drug comprises the following raw materials: a cefotiam crude product, the intermediate of the cefotiam crude product is 7-amino cephalosporanic acid (7-ACA for short), the 7-ACA is prepared by biological fermentation and chemical refining to prepare cephalosporin C, and then the cephalosporin C is chemically cracked or enzymatically hydrolyzed. The preparation method of the cefotiam bulk drug comprises the following operation steps: S1, preparing a first filtrate; S2, preparing a second filtrate; S3, preparing a cefotiam crude product crystal; S4, preparing a cefotiam fine crystal; and S5, preparing a finished product of the cefotiam bulk drug. According to the cefotiam raw material medicine, in the drying process of cefotiam raw material medicine finished product preparation, the modes of hot air flow heating drying and nitrogen gas introduction drying are combined, moisture in a wet product can be conveniently and rapidly taken away, the drying time is shortened, meanwhile, the moisture is reduced, and the drying degree is improved; therefore, the finished cefotiam powder with high purity and good stability can be conveniently obtained.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a raw material medicine of cefotiam. Background technique [0002] Cefotiam is a cephalosporin antibiotic for injection, which belongs to the second-generation cephalosporin antibiotics. The main mechanism of action is to prevent the synthesis of bacterial cell walls to exert a strong bactericidal effect. Raw materials, also known as active pharmaceutical ingredients, are prepared by chemical synthesis, plant extraction or biotechnology, but substances that cannot be taken directly by patients are generally added with excipients and processed to make drugs that can be used directly. [0003] During the preparation process of the existing cefotiam bulk drug, the impurity content is high, and the purity of the finished product is insufficient, and in the preparation process, it is not convenient to quickly remove the moisture inside the cefotiam wet product by adopting...

AI Technical Summary

Problems solved by technology

[0004] Aiming at the deficiencies in the prior art, the present invention provides cefotiam bulk drug, which solves the problem that the existing cefotiam bulk drug proposed in the above-mentioned background technology has high impurity content in the process of preparation, insufficient purity of the finished product, and During the process, it is not convenient to use conventional drying methods to quickly remove the moisture inside the wet product of cefotiam, and its high internal water content may cause hydrolysis and oxidation to affect its stability.