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A kind of brush-like hybrid micelles and preparation method thereof
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A micellar and brush-like technology, applied in chemical instruments and methods, pharmaceutical formulations, emulsion delivery, etc., to achieve large load capacity, stable structure, and easy operation
Active Publication Date: 2021-10-08
ZHEJIANG SCI-TECH UNIV
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However, the micelles prepared by crystallization-driven self-assembly are generally one-dimensional rod-like structures and two-dimensional sheet-like structures. There are still great challenges in the preparation of brush-like micelles, especially in the aspect of adjustable shape. Therefore, how to prepare shape-controllable Brush-like hybrid micelles still need further study
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Embodiment 1
[0042] The preparation method of the brush-like hybrid micelles of the present embodiment comprises the following steps:
[0043] 1. Synthesis of block copolymers PCL-b-P4VP and PCL-b-PDMA
[0044] (1) Synthesis of PCL macromolecular initiator modified by RAFT reagent
[0045] In a glove box filled with nitrogen, add dried toluene solution (2 mL), caprolactone (1.728 g, 15.12 mmol), diphenyl phosphate solution (50.4 mg, 0.216 mmol) and bis End group CTA (54mg, 0.216mmol), stirred at room temperature for 8 hours, the solution was precipitated three times in glacial ether, collected by suction filtration, and synthesized the PCL macroinitiator PCL-CTA modified by RAFT reagent, the PCL-CTA The structural formula is as follows:
[0046]
[0047] (2) Synthesis of PCL-b-P4VP block copolymer
[0048]Add the PCL macromolecular initiator PCL-CTA, initiator azobisisobutyronitrile, solvent 1,4-dioxane, monomer 4-vinylpyridine modified by RAFT reagent successively in the reaction bo...
Embodiment 2
[0062] The difference between the preparation method of the brush-like hybrid micelles of the present embodiment and the first embodiment is that:
[0063] Anchored PCL in carbon nanotubes 60 -b-P4VP 360 During the short-crystal process, the mass of seed micelles: the mass of CNTs is 0.5:1.
[0064] Other steps are the same as in Embodiment 1.
[0065] The present embodiment obtains that the seed grafting density is 0.5, and the brush-shaped hybrid micelles that monomer charge ratio is 20, such as Figure 4 As shown, the aspect ratio is 2.
Embodiment 3
[0067] The difference between the preparation method of the brush-like hybrid micelles of the present embodiment and the first embodiment is that:
[0068] in PCL 60 -b-PDMA 320 During the heteroepitaxial growth of block copolymers, the mass of monomer: the mass of seed micelles was 5:1.
[0069] Other steps are the same as in Embodiment 1.
[0070] The present embodiment obtains that the seed grafting density is 1, and the monomer charge ratio is 5 brush-shaped hybrid micelles, such as Figure 5 As shown, the aspect ratio is 1.
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Abstract
The present invention relates to a kind of preparation method of brushhybrid micelles, comprising: (1) the synthesis of block copolymer PCL-b-P4VP, PCL-b-PDMA; (2) the preparation of seed micelles; (3) Template preparation for anchoring PCL‑b‑P4VP seeds on carbon nanotubes; (4) Tunable epitaxial growth of PCL‑b‑PDMA monomers on seeded micelles. The PCL-b-P4VP rod-shaped seed micelles prepared by ultrasonic breaking in the present invention are anchored on carbon nanotubes by hydrogen bonding, adding PCL-b-PDMA to obtain PCL-b-PDMA in PCL-b-P4VP seeds Brush-like hybrid micelles grown on carbon nanotubes, adjusting the grafting density of seed micelles PCL‑b‑P4VP on carbon nanotubes and changing the mass ratio of seed micelles PCL‑b‑P4VP to monomeric PCL‑b‑PDMA The brush-like structure shape realizes controllable micellar shape.
Description
technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a brush-like hybridmicelle and a preparation method thereof. Background technique [0002] In recent years, the use of active self-assembly to construct complex structures with controllable morphology and order has attracted extensive attention. The biggest feature of active self-assembly is that it is active as the end of the seed structure, and the newly added monomer can continuously grow and extend at the active end of the seed, so controlling the formation of active sites can construct complex structures with different dimensions. The concept of active self-assembly comes from the field of polymerchemistry. At present, in the field of polymers, multi-dimensional complex nano- or micro-scale structures have been successfully assembled using block copolymers combined with different intermolecular forces. For organic small molecule systems, the methods ...
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