Application of Apelin protein in preparation of reagent for diagnosing respiratory system diseases

Abstract

The invention discloses an application of Apelin protein in preparation of a reagent for diagnosing respiratory system diseases. What is found for the first time is that the combination of Apelin-13, especially Apelin-13, GP73 (Golgi Transmembrane Glycoprotein) and Cys-C (cystatin C), can be used as a diagnostic marker for diagnosing respiratory system diseases, especially acute lung injury, and the detection specificity of acute lung injury can be effectively improved.

Description

technical field [0001] The invention belongs to the field of medical detection, in particular to the application of Apelin protein in the preparation of reagents for diagnosing respiratory diseases. Background technique [0002] Respiratory system disease is a common and frequently-occurring disease. The main lesions are in the trachea, bronchi, lungs, and chest cavity. Mild cases often cause coughing, chest pain, and respiratory problems. Severe cases have dyspnea, hypoxia, and even death due to respiratory failure. The death rate in the city is the third, while in the countryside it is the first. What should be paid more attention to is that due to air pollution, smoking, population aging and other factors, chronic obstructive pulmonary disease (referred to as COPD, including chronic bronchitis, emphysema, pulmonary heart disease), bronchial asthma, lung cancer, The morbidity and mortality of diseases such as pulmonary diffuse interstitial fibrosis and pulmonary infection...

AI Technical Summary

Problems solved by technology

[0005] Although after nearly half a century of research, people have a deep understanding of the pathogenesis, pathophysiology, diagnosis and treatment of acute lung injury, but the mechanism of acute lung injury is very complex, involving infection, inflammation, immunity and tissue Most of the patients are already in the severe stage of acute lung injury when they see a doctor, which is very difficult in the clinical diagnosis and treatment. is less than 30 times / min), its oxygenation index is generally between 200-300mmHg, the body is not seriously hypoxic, and can basically meet the normal needs of organ functions or the body's various organ functions are in the compensatory period. The symptoms of patients in this stage are not typical, which are often ignored by clinicians. If they cannot be effectively identified and effective intervention measures are taken, patients tend to develop in a more serious direction and develop into the stage of ARDS with typical symptoms. serious, the mortality rate increased significantly

At present, there is still no effective method for early identification of acute lung injury and reduction of mortality in clinical practice

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