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Application of dihydroberberine in preparation of medicine for treating ulcerative colitis

A technology for ulcerative colitis and dihydroberberine, applied in the field of medicine, can solve the problems of difficulty in intestinal epithelial absorption, hinder the application of berberine, low bioavailability, etc. Guaranteed curative effect

Pending Publication Date: 2021-04-30
遵义医科大学珠海校区
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of berberine in the treatment of ulcerative colitis has been hampered by its low bioavailability, poor solubility, and poor absorption by the intestinal epithelium

Method used

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  • Application of dihydroberberine in preparation of medicine for treating ulcerative colitis
  • Application of dihydroberberine in preparation of medicine for treating ulcerative colitis
  • Application of dihydroberberine in preparation of medicine for treating ulcerative colitis

Examples

Experimental program
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Effect test

preparation example 1

[0066] Pharmaceutical preparation example 1: tablet

[0067] Take 500g of dihydroberberine, add 480g of lactose and 754g of starch and mix evenly, use 7% starch slurry 350g as a binder, wet granulate, dry, add 16g of magnesium stearate, mix evenly, and press into each tablet containing Dihydroberberine 50mg tablets 10,000 pieces, each with a net weight of 0.21g. Orally, for the treatment of ulcerative colitis. Symptoms: Abdominal pain, diarrhea, blood in the stool, weight loss, etc.

preparation example 2

[0068] Pharmaceutical Preparation Example 2: Capsules

[0069] Take 500g of dihydroberberine, add 980g of lactose, 1254g of starch, mix well, use 7% starch slurry 350g as binder, wet granulate, dry, add 16g of magnesium stearate, mix well, fill to No. 1 capsule Made into 10000 capsules, each capsule contains 50mg of dihydroberberine, and each capsule has a net weight of 0.31g. Orally, for the treatment of ulcerative colitis. Symptoms: Abdominal pain, diarrhea, blood in the stool, weight loss, etc.

preparation example 3

[0070] Pharmaceutical Preparation Example 3: Granules

[0071]Weigh 100g of dihydroberberine and add it to an appropriate amount of β-cyclodextrin to make an inclusion complex, add an appropriate amount of sucrose powder, microcrystalline cellulose, and starch slurry, mix evenly, gradually add ethanol and water to make granules, and carry out Subpackage. The specifications are granules containing 50mg of dihydroberberine, and the net weight of each pack is 7g. Take it with boiled water and take it orally for the treatment of ulcerative colitis. Symptoms: Abdominal pain, diarrhea, blood in the stool, weight loss, etc.

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Abstract

The invention belongs to the field of medicines, and discloses an application of dihydroberberine in preparation of a medicine for treating ulcerative colitis, and the structural formula of the dihydroberberine is shown as a formula (I). The dihydroberberine can significantly improve general symptoms of ulcerative colitis mice, improve pathological changes, reduce myeloperoxidase activity, inhibit the content of pro-inflammatory cytokines and increase the expression of colon tight junction protein, so that the intestinal mucosa barrier function is improved, and the ulcerative colitis treatment effect is significant.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to the application of dihydroberberine in the preparation of medicines for treating ulcerative colitis. Background technique [0002] Ulcerative colitis (Ulcerative colitis, UC) is a subtype of inflammatory bowel disease (Inflammatory Bowel Disease, IBD), is a chronic refractory inflammatory disease, clinical manifestations of abdominal pain, diarrhea, blood in the stool, weight loss . Furthermore, this intractable gastrointestinal disorder severely impairs health and quality of life and creates a high risk of colorectal cancer in IBD patients. Epidemiological reports show that the incidence and prevalence of UC are increasing globally over time, especially in developing countries. Due to the protracted course of UC and its capriciousness, it not only causes mental and physical pain to patients, but also brings a heavy economic burden to families and society. The pathogenesis of UC is not...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61P1/04A61K36/718
CPCA61K31/4375A61K36/718A61P1/04
Inventor 李彩兰鲁强
Owner 遵义医科大学珠海校区
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