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Celery seed extract as well as preparation method and application thereof

A technology of celery seed extract and celery seed, which is applied in the fields of natural medicinal chemistry and food and medicine, can solve the problems of unclear active ingredients, achieve the effects of preventing gout, reducing serum uric acid, and clear ingredients

Active Publication Date: 2021-04-30
SHANDONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The extraction method of the present invention can overcome the technical problem that the active ingredient is not clear when extracting the active ingredient from celery seed in the prior art

Method used

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  • Celery seed extract as well as preparation method and application thereof
  • Celery seed extract as well as preparation method and application thereof
  • Celery seed extract as well as preparation method and application thereof

Examples

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preparation example Construction

[0029] In one embodiment of the present invention, a kind of preparation method of celery seed extract is provided, comprises the steps:

[0030] 1) Get dried celery seeds and grind them into celery seed powder;

[0031] 2) extracting and removing the volatile oil compounds in the celery seed with an organic solvent;

[0032] 3) Soaking the celery seeds after organic solvent extraction in step 2) in an extractant, soaking at room temperature for extraction or reflux extraction; the extractant is ethanol or an aqueous solution of ethanol;

[0033] 4) Concentrating the ethanol-water extract obtained in step 3), and obtaining celery seed extract by column chromatography.

[0034] In a specific embodiment, the specific operation steps of step 2) are: take dried celery seeds, pulverize, finely grind into a fine powder, add 5-10 times the volume of organic solvent in dry celery seeds, soak and extract at room temperature 1 time or reflux extraction 3 times; each soaking time at ro...

Embodiment 1

[0053] Crush 20 grams of celery seeds, finely grind them, add 3 times the volume of celery seed powder, organic solvent ethyl acetate, stir at room temperature for 5.0 hours, filter to obtain celery seed residue, repeat 3 times, combine celery seed residue, and dry in the air spare.

[0054] Get above-mentioned dried celery seed dregs, add mass fraction and be 100% ethanol reflux 1.5 hours at 80 ℃, filter, obtain the ethanol extraction solution, repeat adding this ethanol reflux extraction 3 times, the extracts obtained are combined, reduced Concentrate under reduced pressure to obtain the ethanol crude extract of celery seed.

[0055] According to the weight ratio of 1 times the amount of silica gel sample mixing, 35 times the amount of silica gel column packing, petroleum ether-ethyl acetate-methanol gradient elution, collect each fraction, analyze and combine the components containing apigenin / apigenin, and reduce pressure After concentration, 1.3 g of refined celery seed ...

Embodiment 2

[0059] Crush 40 grams of celery seed, grind it finely, add 3 times the volume of celery seed powder, organic solvent ethyl acetate, stir at room temperature for 5.0 h, filter to obtain celery seed residue, repeat 3 times, combine celery seed residue, and dry in the air spare.

[0060] Get above-mentioned dried celery seed dregs, add mass fraction and be 95% ethanol 80 ℃ of reflux 1.5 hours, filter, obtain the ethanol extraction solution, add this ethanol reflux extraction repeatedly 3 times, the extract that obtains is combined, reduce Concentrate under reduced pressure to obtain the ethanol crude extract of celery seed.

[0061] According to the weight ratio of 1 times the amount of silica gel sample mixing, 35 times the amount of silica gel column packing, petroleum ether-ethyl acetate-methanol gradient elution, collect each fraction, analyze and combine the components containing apigenin / apigenin, and reduce pressure After concentration, 2.0 g of refined celery seed extrac...

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Abstract

The invention relates to the technical field of natural medicinal chemistry and food medicine, in particular to a celery seed extract and a preparation method and an application thereof. The celery seed extract is prepared from apigenin and apigenin, and the preparation method comprises the following steps: smashing celery seeds into celery seed powder; extracting and removing volatile oil compounds in celery seeds by using an organic solvent, extracting the celery seeds by using an ethanol-water solution, concentrating, and carrying out column chromatography to obtain the celery seed extract. The precise active ingredient in celery seed for lowering blood uric acid is obtained. The method is simple to operate, clear in extract effect and simple in preparation process, and the obtained celery seed extract is clear in component and can be used for health food or preventive drugs or nourishment to prevent and treat various diseases of human bodies, such as reduction of blood uric acid, relief and treatment of ventilation, prevention of gout and the like.

Description

technical field [0001] The invention relates to the technical fields of natural medicine chemistry and food medicine, in particular to a preparation method and application of celery seed extract. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Celery is divided into cress and celery, which is the full name of Apiumgrauens L.var.dulcedc. of Umbelliferae. It is not only a daily delicacy on our table, but also available for medicinal purposes. Celery seeds are taken from the small flowers of celery, so the seeds are very small in shape, oval in shape, mostly tan or dark brown in color, containing eucalyptol, phosphomethoxyphenol, cymelide, Apigenin, linolenic acid, volatil...

Claims

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Application Information

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IPC IPC(8): A61K36/23A61P19/06A23L33/105
CPCA61K36/23A61P19/06A23L33/105A61K2236/333A61K2236/33A61K2236/55A61K2236/39A23V2002/00A23V2200/30A23V2250/21A23V2300/14A23V2300/02A23V2300/38
Inventor 宋淳张友明江蓓胡昭张超
Owner SHANDONG UNIV
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