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A kind of celery seed extract and its preparation method and application

A technology of celery seed extract and celery seed, which is applied in the fields of natural medicinal chemistry and food medicine, can solve problems such as unclear active ingredients, and achieve the effect of preventing gout, simple preparation process, and clear ingredients

Active Publication Date: 2022-06-28
SHANDONG UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The extraction method of the present invention can overcome the technical problem that the active ingredient is not clear when extracting the active ingredient from celery seed in the prior art

Method used

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  • A kind of celery seed extract and its preparation method and application
  • A kind of celery seed extract and its preparation method and application
  • A kind of celery seed extract and its preparation method and application

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preparation example Construction

[0029] In one embodiment of the present invention, a preparation method of celery seed extract is provided, comprising the steps:

[0030] 1) Take the dried seeds of celery and pulverize them into celery seed powder;

[0031] 2) Extract and remove volatile oil compounds in celery seeds with organic solvent;

[0032] 3) soaking the celery seeds after the organic solvent extraction in step 2) in an extractant, soaking at room temperature for extraction or reflux extraction; the extractant is an aqueous solution of ethanol or ethanol;

[0033] 4) The ethanol-water extract obtained in step 3) is concentrated, and the celery seed extract is obtained by column chromatography.

[0034] In a specific embodiment, the specific operation steps of step 2) are: taking dry celery seeds, pulverizing them, finely grinding them into fine powder, adding 5-10 times the volume of an organic solvent to dry celery seeds, soaking and extracting at room temperature 1 or 3 times of reflux extraction...

Embodiment 1

[0053] Pulverize 20 grams of celery seeds, grind them finely, add 3 times the volume of celery seed powder with ethyl acetate as an organic solvent, stir at room temperature for 5.0 h, filter to obtain celery seed residues, repeat 3 times, combine celery seed residues, and air dry spare.

[0054] Take the above-mentioned dried celery seed residue, add 100% ethanol with a mass fraction of 100% and reflux at 80°C for 1.5 hours, filter to obtain an ethanol extraction solution, repeat adding the ethanol for reflux extraction 3 times, combine the obtained extracts, reduce Pressed and concentrated to obtain the crude ethanol extract of celery seeds.

[0055] Mix samples with 1 times the amount of silica gel by weight, pack 35 times the amount of silica gel into a column, and elute with petroleum ether-ethyl acetate-methanol gradient, collect each fraction, analyze and combine the components containing apigenin / apigenin, and reduce the pressure. After concentration, 1.3 grams of cel...

Embodiment 2

[0059] Pulverize 40 grams of celery seeds, grind them finely, add 3 times the volume of celery seed powder with ethyl acetate as an organic solvent, stir at room temperature for 5.0 h, filter to obtain celery seed residues, repeat 3 times, combine celery seed residues, and air dry spare.

[0060] Take the above-mentioned dried celery seed residue, add 95% ethanol with a mass fraction of 95% and reflux at 80°C for 1.5 hours, filter to obtain an ethanol extraction solution, repeat adding the ethanol for reflux extraction 3 times, combine the obtained extracts, reduce Pressed and concentrated to obtain the crude ethanol extract of celery seeds.

[0061] Mix samples with 1 times the amount of silica gel by weight, pack 35 times the amount of silica gel into a column, and elute with petroleum ether-ethyl acetate-methanol gradient, collect each fraction, analyze and combine the components containing apigenin / apigenin, and reduce the pressure. After concentration, 2.0 grams of celer...

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Abstract

The present invention relates to the technical fields of natural medicinal chemistry and food medicine, in particular to a celery seed extract and its preparation method and application, the composition of the celery seed extract is apigenin and apigenin, and the preparation method comprises Celery seeds are crushed into celery seed powder, extracted with an organic solvent and the volatile oil compounds therein are removed, then the celery seeds are extracted and concentrated with ethanol-water solution, and column chromatography is used to obtain the celery seed extract. The precise active ingredient for lowering blood uric acid in celery seed is obtained, the operation is simple, the effect of the extract is clear, the preparation process is simple, and the obtained celery seed extract has clear components, which can be used for health food or preventive medicine or nutritional product, prevent And treat a variety of human diseases, such as lowering blood uric acid, relieving and treating ventilation, preventing gout, etc.

Description

technical field [0001] The invention relates to the technical field of natural medicinal chemistry and food medicine, in particular to a preparation method and application of a celery seed extract. Background technique [0002] The information disclosed in this Background section is only for enhancement of understanding of the general background of the invention and should not necessarily be taken as an acknowledgement or any form of suggestion that this information forms the prior art already known to a person of ordinary skill in the art. [0003] Celery is divided into cress and celery, which is the full name of the Umbelliferae Apiumgrauens L.var.dulcedc. It is not only a daily delicacy on our table, but also medicinal. Celery seeds are taken from the small flowers of celery, so the seeds are also very small, oval in shape, mostly tan or dark brown in color, containing eucalyptol, phosphomethoxyphenol, cymenolide, Apigenin, linolenic acid, volatile oils, flavonoids, bo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/23A61P19/06A23L33/105
CPCA61K36/23A61P19/06A23L33/105A61K2236/333A61K2236/33A61K2236/55A61K2236/39A23V2002/00A23V2200/30A23V2250/21A23V2300/14A23V2300/02A23V2300/38
Inventor 宋淳张友明江蓓胡昭张超
Owner SHANDONG UNIV
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