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Antifungal flutrimazole shampoo preparation and its preparation process

A technology of flutrimazole and hair shampoo, which is applied in the field of pharmaceutical preparations and can solve the problems of poor solubility and poor stability of raw materials

Active Publication Date: 2022-05-13
武汉久安药物研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a kind of new medicated shampoo for the defective of prior art, be used for local treatment scalp pityriasis (dandruff), seborrheic dermatitis; Antifungal flutrimazole of the present invention Shampoo preparation, which solves the technical problems of poor solubility and poor stability of raw materials, and has good softness, conditioning and hair cleansing effects

Method used

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  • Antifungal flutrimazole shampoo preparation and its preparation process
  • Antifungal flutrimazole shampoo preparation and its preparation process
  • Antifungal flutrimazole shampoo preparation and its preparation process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Embodiment 1 provides a kind of antifungal shampoo preparation with flutrimazole, and its composition is shown in the following table:

[0070]

[0071]

[0072] The preparation technology of this antifungal shampoo preparation with flutrimazole is as follows:

[0073] S1. Preparation of flutrimazole solution: disperse flutrimazole in Tween 20, propylene glycol, glycerin, heat in an oil bath at 100°C until dissolved, and let cool for later use;

[0074]S2. Add water, EDTA2Na, AES, PEG-75 lanolin, and flutrimazole solution to the batching pot sequentially in a water bath at 80°C, stir until dissolved and evenly mixed, and let cool to 50°C;

[0075] S3. Mix water-soluble olive oil, cocamide DEA, essence, PPG-3 octyl ether and set aside;

[0076] S4. Add CAB35, the solution obtained in step S3, acrylic acid (ester) copolymer (SF-1) aqueous solution, 10% sodium hydroxide solution, emulsified silicone oil 7137, and emulsified silicone oil 1785 to the above-mentioned b...

Embodiment 2

[0079] Embodiment 2 provides a kind of antifungal flutrimazole hair shampoo preparation, and its composition is as shown in the following table:

[0080]

[0081] The preparation technology of this antifungal shampoo preparation with flutrimazole is as follows:

[0082] S1. Preparation of flutrimazole solution: disperse flutrimazole in Tween 20 and propylene glycol, heat in an oil bath at 100°C until dissolved, and let cool for later use;

[0083] S2. Add water, EDTA2Na, APG0810, CAB35, and flutrimazole solution to the batching pot in a 50°C water bath, and stir until dissolved;

[0084] S3. Add polydimethylsiloxane propyl PG-betaine, imidazolidinyl urea, Aculyn22 aqueous solution, and sodium hydroxide solution to the above batching pot in sequence, and stir until dissolved and mixed;

[0085] S4. Slowly add sodium chloride to the above-mentioned batching pot to adjust the viscosity, and replenish the water to the full amount; let it cool and defoam to obtain the antifunga...

Embodiment 3

[0087] Embodiment 3 provides a kind of antifungal flutrimazole hair shampoo preparation, and its composition is shown in the following table:

[0088]

[0089] The preparation technology of this antifungal shampoo preparation with flutrimazole is as follows:

[0090] S1. Preparation of flutrimazole solution: disperse flutrimazole in Tween 20, propylene glycol, glycerin, heat in an oil bath at 100°C until dissolved, and let cool for later use;

[0091] S2. Add water, EDTA2Na, AES, APG0810, PEG-75 lanolin, and flutrimazole solution to the batching pot in an 80°C water bath, stir until dissolved and mix well, and let cool to 50°C;

[0092] S3. Mix water-soluble olive oil, cocamide DEA, essence, PPG-3 octyl ether and set aside;

[0093] S4. Add CAB35, the solution obtained in step S3, acrylic acid (ester) copolymer (SF-1) aqueous solution, 10% sodium hydroxide solution, emulsified silicone oil 7137, and emulsified silicone oil 1785 to the above-mentioned batching pot in sequen...

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Abstract

The invention provides an antifungal flutrimazole shampoo preparation and a preparation process thereof. The shampoo preparation comprises the following components by weight: 0.1%-3.0% of flutrimazole, 10%-80% of surfactant, 1%-10% of solubilizer, 0%-8% of auxiliary Solvent, 1%-8% conditioner, 0.5%-4% rheology modifier, 0.05%-0.1% chelating agent, 0.05%-1% preservative, 0%-1% pH adjuster, 0%‑0.5% fragrance, the balance is purified water. The invention can provide patients with new medicated shampoo for local treatment of scalp pityriasis (dandruff) and seborrheic dermatitis. At the same time, it solves the technical problem of poor solubility and poor stability of flutrimazole, and has good smoothing, conditioning and hair cleansing effects. The invention also provides a preparation process of the antifungal flutrimazole shampoo preparation, which is simple, feasible, highly controllable and easy for industrial production.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and relates to medicinal hair shampoos, in particular to an antifungal flutrimazole shampoo preparation and a preparation process thereof. Background technique [0002] Scalp pityriasis (dandruff) and seborrheic dermatitis are common and frequently-occurring diseases in dermatology. They can occur in all ages and are mainly caused by fungal infections. With the widespread application of high-efficiency broad-spectrum antibiotics, adrenal cortex hormones and immunosuppressants in recent years, as well as the gradual increase in human organ tissue transplantation, surgical interventional therapy, and the proliferation of many viruses, fungal infections have become increasingly serious. The incidence of regional infections has increased significantly, and the emergence of some drug-resistant strains has also challenged the treatment of fungal diseases. [0003] According to rese...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4174A61P17/00A61P31/10A61P17/08A61K8/49A61Q5/02A61Q5/00A61Q5/12A61Q17/00
CPCA61K31/4174A61P17/00A61P31/10A61P17/08A61K8/4946A61Q5/02A61Q5/006A61Q5/12A61Q17/005A61K2800/782
Inventor 金牮马冬冬陈寅郝超张桂森
Owner 武汉久安药物研究院有限公司