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A kind of ROS-responsive polymer material and preparation method thereof

A polymer material and responsive technology, applied in the fields of polymer synthesis and biomaterials, can solve the problems of low reaction sensitivity and complex process, and achieve the effects of reducing ROS concentration, simple preparation method and sensitive response.

Active Publication Date: 2022-06-07
INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the prior art generally has the disadvantages of complex process and low reaction sensitivity

Method used

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  • A kind of ROS-responsive polymer material and preparation method thereof
  • A kind of ROS-responsive polymer material and preparation method thereof
  • A kind of ROS-responsive polymer material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A preparation method of ROS-responsive polymer material (see figure 1 ), including the following steps:

[0031] (1) Mix polyester monomers (lactide ① and glycolide ② with a molar ratio of 3:1), initiator inositol and catalyst stannous octoate into a polymerization tube, and repeat vacuuming to seal the polymerization tube , first heated to 250 ℃ with a heating mantle to melt inositol, and then placed in a 160 ℃ oven for polymerization for 8 hours to obtain polylactic acid polyglycolic acid (6S-PLGA ③) with an average molecular weight of 8000, and the crude product was purified and reprecipitated 3 times, vacuum dried to constant weight;

[0032] The molar ratio of the above polyester monomer, initiator and catalyst is 6000:50:1;

[0033] (2) Using the 6S-PLGA obtained in step (1) as a raw material to prepare 6S-PLGA-Ph-OH④; synthesizing PEG-Ph-OH⑦ with PEG⑤ with an average molecular weight of 4000.

[0034] Dissolve 2mmol p-hydroxybenzoic acid and 2mmol N,N-dimethyl...

Embodiment 2

[0046] A preparation method of a ROS-responsive polymer material, comprising the following steps:

[0047] (1) The polyester monomer glycolic acid, the initiator ethylene glycol and the catalyst stannous isooctanoate were mixed in a polymerization tube, and the polymerization tube was sealed by repeated vacuuming, and then placed in a 150°C oven for 6 hours to obtain an average molecular weight of 20,000 The crude product was purified, reprecipitated 3 times, and dried in vacuo to constant weight;

[0048] The molar ratio of polyester monomer, initiator and catalyst is 34500:100:1;

[0049] (2) PGA-Ph-COO-Ph-OH is prepared by using the PGA obtained in step (1) as a raw material; PEG-Ph-OH is synthesized with PEG with an average molecular weight of 2000.

[0050] Dissolve 8mmol p-hydroxybenzoic acid and 8mmol DMF in 20mL THF to obtain solution one; dissolve 8mmol oxalyl chloride in 20mL THF, drop into solution one; add 0.8mmol PGA and 2mmol triethylamine, stir at room temperat...

Embodiment 3

[0058] A preparation method of a ROS-responsive polymer material, comprising the following steps:

[0059] (1) Mix polyester monomers (succinic acid and butanediol with a molar ratio of 1:1), initiator glycerol and catalyst aluminum hydroxide into the polymerization tube, and after repeated vacuuming to seal the polymerization tube, Place the reaction in a 200°C oven for 12 hours to obtain polybutylene succinate (3S-PBS) with an average molecular weight of 50,000; the crude product is purified, reprecipitated for 3 times, and dried under vacuum to constant weight;

[0060] The molar ratio of polyester monomer, initiator and catalyst is 63000:200:1;

[0061] (2) 3S-PBS-Ph-OH was prepared by using the 3S-PBS obtained in step (1) as a raw material; PEG-Ph-COO-Ph-OH was synthesized with PEG with an average molecular weight of 5000.

[0062] Dissolve 30 mmol of p-hydroxybenzoic acid and 30 mmol of DMF in 50 mL of THF to obtain solution one; dissolve 30 mmol of oxalyl chloride in 5...

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Abstract

The invention discloses a ROS-responsive polymer material and a preparation method thereof. The preparation steps are as follows: (1) polymerizing polyester monomers under the action of an initiator and a catalyst to obtain polyester; (2) preparing polyester ‑Ar‑OH; synthesis of PEG‑Ar‑OH, (3) preparation of PEG‑Ar‑OCOCOCl; (4) reaction of excess PEG‑Ar‑OCOCOCl with polyester‑Ar‑OH to obtain a ROS responsive polymer material; The method of the invention is simple, and the polymer material of the invention can scavenge excessive ROS, and has anti-oxidation and anti-inflammation effects. A nano-carrier system prepared by a ROS-responsive polymer material can continuously reduce the ROS concentration and restore the normal ROS level. Therefore, ROS-responsive polymer materials can be used as an effective carrier to improve the oxidative microenvironment.

Description

technical field [0001] The invention relates to a ROS-responsive polymer material and a preparation method, belonging to the fields of biological materials and polymer synthesis. Background technique [0002] Reactive oxygen species (ROS) are produced by biological aerobic metabolism, mainly including hydrogen peroxide, hydroxyl radicals, superoxide ions and oxygen molecules. Reactive oxygen species play a key role in protein folding, signal transduction, cell proliferation, differentiation and migration, defense response, respiration, and oxidative damage. Under physiological conditions, low levels of reactive oxygen species are necessary to maintain the normal function of cells, regulating oxygen balance and participating in various signaling pathways; when inflammation occurs, the concentration of reactive oxygen species increases, which induces oxidative stress in cells, causing cell damage and apoptosis. The pathogenic mechanisms of reactive oxygen species include: (1...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G81/00A61K47/34A61P29/00A61P39/06
CPCC08G81/00A61K47/34A61P29/00A61P39/06
Inventor 杨菁梁晓玉李轩领李慧洋
Owner INST OF BIOMEDICAL ENG CHINESE ACAD OF MEDICAL SCI