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Degradable composite artificial blood vessel and preparation method and application thereof

An artificial blood vessel, tubular technology, applied in the field of degradable composite artificial blood vessel and its preparation, can solve the problems of smaller diameter or capillary blockage, artificial blood vessel graft failure, acute thrombosis, etc., to reduce the incidence rate and vascular rupture rate , regulate the expression of smooth muscle cell configuration, and improve the effect of safety

Active Publication Date: 2021-05-28
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, this may cause the artificial blood vessel to cause coagulation reaction in a short period of time, resulting in acute thrombus, resulting in the failure of the artificial blood vessel graft; Causes blockage of smaller diameter or capillaries as blood travels throughout the body

Method used

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  • Degradable composite artificial blood vessel and preparation method and application thereof
  • Degradable composite artificial blood vessel and preparation method and application thereof
  • Degradable composite artificial blood vessel and preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] The porous hollow tubular polylactic acid (Mn=130000) matrix prepared by the salting-out method is 10 cm long, 5 mm in inner diameter, and 3 mm thick, and is equipped with 0.1 mol / L NaOH aqueous solution. The matrix is ​​immersed in the alkaline solution at 37 ° C for 36 h, taken out and cleaned. In addition, 30 mg / mL of norbornene-modified collagen, 10 mg / mL of stearyl mercaptan, and 1 mg / mL of phenyl (2,4,6-trimethylbenzoyl) phosphate lithium salt were prepared. A polytetrafluoroethylene rod with a length of 4.8 mm and a length of 20 cm was immersed in the solution for 20 minutes until the pre-hydrogel solution filled the pores of the matrix, and then rotated at a speed of 20 rad / min and irradiated with 365 nm ultraviolet light for 3 minutes to catalyze gelation to obtain an artificial blood vessel , the inner surface of the hydrogel composite blood vessel is relatively smooth. The composite artificial blood vessel was freeze-dried, and the surface roughness was measu...

Embodiment 2

[0036] Electrospinning degradable polyurethane (Mn=60000, polyεcaprolactone as soft segment, hexamethylene diisocyanate as chain extender self-synthesized) receiving distance 20cm, solvent N,N-dimethylformamide, concentration 20 %, the voltage is 17kv, the speed of the receiving device is 5rad / min, and a Y-shaped tube with an inner diameter of 4mm is obtained. The two upper sections of the Y-shaped section are 5cm long, the bottom section is 8cm long, and the thickness is 0.3mm. The porosity is about 70%, and the pore diameter is about 2μm. Dopamine is configured Solution concentration 2mg / ml, buffer solution with pH of 8.3, under nitrogen protection. Submerge the matrix in the solution for 24 hours, prepare 150ml of 0.05g / ml hyaluronic acid aqueous solution, weigh 1-(3-dimethylaminopropyl)-3 - Ethylcarbodiimide hydrochloride (EDCI) 0.5g and N-hydroxysuccinimide (NHS) 0.3g, ice-water bath for 2h, submerge the matrix in the aqueous solution containing hyaluronic acid at 20°C for...

Embodiment 3

[0038] Soak natural silk in 0.05% sodium carbonate aqueous solution for degumming, after drying to obtain a solid, dissolve it again with 9mol / L lithium bromide aqueous solution, place the aqueous solution in a 3500 dialysis belt and use deionized water to dialyze for 96 hours to obtain a silk fibroin aqueous solution. Take self-synthesized polyglycerol sebacate (Mn=10000) and poly-L-lactic acid (Mn=50000), according to the mass ratio of 1:3, using hexafluoroisopropanol to prepare 25% mass volume ratio Solution, at 30°C, positive voltage 20kv, receiving distance 15cm, using a rod with a diameter of 3mm to receive, injection pump flow rate 2.5ml / h, electrospinning for 4h, to obtain a tubular stent with a length of 10cm and a thickness of 0.2mm, using 5 % Hexamethylenediamine in isopropanol solution for 1 hour, and washed with deionized water for 3 times. Weigh 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) 0.5g and N-hydroxysuccinimide (NHS) 0.3g, heparin so...

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Abstract

The invention discloses a degradable composite artificial blood vessel and a preparation method thereof, the degradable composite artificial blood vessel is composed of a hollow tubular matrix with a porous hydrophilic surface and a hydrogel component, pores of the matrix are filled with the hydrogel, and the matrix and the hydrogel are degradable. The porosity of the matrix is 50-99%, the aperture is 0.5-200 [mu] m, and the matrix can be modified by an anticoagulant component. The hydrogel can load drugs, cells and bioactive substances at the same time. The porous hydrogel composite artificial blood vessel not only has excellent mechanical properties, but also can prevent blood leakage and blood oozing, and has excellent short-term and long-term anticoagulation effects; the aneurysm occurrence rate is reduced, and the functions of collecting host cells and promoting, regulating and controlling autologous tissue regeneration are achieved. The degradable artificial blood vessel prepared by the preparation method of the degradable artificial blood vessel is uniform in wall thickness, simple in preparation process and easy for industrial production, can reduce the expansion performance of the hydrogel and increase the biological activity, and has a wide application prospect as a tissue engineering artificial blood vessel.

Description

technical field [0001] The invention relates to the field of medical implants, in particular to a degradable composite artificial blood vessel and its preparation method and application. Background technique [0002] Cardiovascular disease has now become one of the major diseases threatening human health, ranking first among all diseases in both morbidity and mortality. According to the prediction of the World Health Organization, by 2030, the number of people dying of cardiovascular-related diseases in the world will increase to 23.3 million each year. The number of cardiovascular diseases in my country is increasing year by year with the changes in people's living habits and the aging of the population. For example, coronary heart disease, lower extremity arteriosclerotic obliterans, chronic renal failure and other vascular diseases, conventional effective treatment Means include vascular bypass surgery and interventional therapy. For blood vessels with severe stenosis or...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/06
CPCA61F2/06A61F2210/0004Y02W90/10
Inventor 叶霖冯增国耿雪谷涌泉
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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