Preparation method of abalone shell powder/ZnO composite material doped intelligent hydrogel wound dressing with bacteriostatic effect

A composite material and antibacterial technology are applied in the field of smart hydrogel wound dressings and their preparation, which can solve problems such as side effects and achieve the effects of good biocompatibility, convenient operation and low cost.

Active Publication Date: 2021-05-28
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the use of systemic antibiotics may cause side effects such as nephropathy, neuropathy, and gastrointestinal disorders

Method used

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  • Preparation method of abalone shell powder/ZnO composite material doped intelligent hydrogel wound dressing with bacteriostatic effect
  • Preparation method of abalone shell powder/ZnO composite material doped intelligent hydrogel wound dressing with bacteriostatic effect
  • Preparation method of abalone shell powder/ZnO composite material doped intelligent hydrogel wound dressing with bacteriostatic effect

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Experimental program
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Effect test

Embodiment 1

[0053] A preparation method of an intelligent hydrogel wound dressing doped with antibacterial abalone shell powder / ZnO composite material, comprising the following steps:

[0054] (1) Wash the abalone shell with tap water and soak it in 8% sodium hydroxide solution for 1 hour, then wash it with distilled water;

[0055] (2) Dry the abalone shell obtained in step (1) in a blast drying oven at 100°C for 24 hours;

[0056] (3) Put the abalone shell obtained in step (2) into a multi-functional pulverizer, and pass through a 100-mesh sieve;

[0057] (4) Grinding the abalone shell powder obtained in step (3) with a planetary ball mill for 48 hours, then placing it in a muffle furnace at 1100°C for calcination for 2 hours, and grinding in a mortar to obtain the abalone shell powder carrier;

[0058] (5) Weigh 29.7g of zinc nitrate hexahydrate into a three-neck flask, add 100ml of distilled water to dissolve under the condition of constant temperature stirring at 90°C;

[0059] (6)...

Embodiment 2

[0068] A preparation method of an intelligent hydrogel wound dressing doped with antibacterial abalone shell powder / ZnO composite material, comprising the following steps:

[0069] (1) Wash the abalone shell with tap water and soak it in 8% sodium hydroxide solution for 1 h, then wash it with distilled water;

[0070] (2) Dry the abalone shells obtained in step (1) in a blast drying oven at 100 °C for 24 h;

[0071] (3) Put the abalone shell obtained in step (2) into a multi-functional pulverizer, and pass through a 100-mesh sieve;

[0072] (4) The abalone shell powder obtained in step (3) was ball-milled with a planetary ball mill for 48 h, then placed in a muffle furnace at 1100 °C for 2 h, and ground in a mortar to obtain the abalone shell powder carrier;

[0073] (5) Weigh 29.7 g of zinc nitrate hexahydrate into a three-necked flask, and add 100 ml of distilled water to dissolve under constant temperature stirring at 90 °C;

[0074] (6) Weigh 4.0 g of sodium hydroxide an...

Embodiment 3

[0083] A preparation method of an intelligent hydrogel wound dressing doped with antibacterial abalone shell powder / ZnO composite material, comprising the following steps:

[0084] (1) Wash the abalone shell with tap water and soak it in 8% sodium hydroxide solution for 1 hour, then wash it with distilled water;

[0085] (2) Dry the abalone shell obtained in step (1) in a blast drying oven at 100°C for 24 hours;

[0086] (3) Put the abalone shell obtained in step (2) into a multi-functional pulverizer, and pass through a 100-mesh sieve;

[0087] (4) Grinding the abalone shell powder obtained in step (3) with a planetary ball mill for 48 hours, then placing it in a muffle furnace at 1100°C for calcination for 2 hours, and grinding in a mortar to obtain the abalone shell powder carrier;

[0088] (5) Weigh 29.7g of zinc nitrate hexahydrate into a three-neck flask, add 100ml of distilled water to dissolve under the condition of constant temperature stirring at 90°C;

[0089] (6)...

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Abstract

The invention belongs to the technical field of medical materials, and relates to a preparation method of an abalone shell powder / ZnO composite material doped intelligent hydrogel wound dressing with a bacteriostatic effect. According to the interface and phase effect of a material, the abalone shell powder / ZnO composite material, chitosan powder and a sodium alginate solution form uniform slurry by utilizing a material preparation technology and method, glucolactone is selected as a proton donor, the abalone shell powder / ZnO composite material doped pure physical crosslinked chitosan / sodium alginate dual-network intelligent hydrogel dressing with the bacteriostatic effect is prepared in situ. The selected materials are good in biocompatibility and free of cytotoxicity, and the dressing can inhibit bacterial infection and promote wound healing.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to an intelligent hydrogel wound dressing doped with abalone shell powder / ZnO composite material and a preparation method thereof. Background technique [0002] Skin wound infections in trauma and surgical wounds caused by various microorganisms are very common. According to relevant data, up to 10% of hospitalized patients worldwide are affected by skin and soft tissue infections. Up to 5% of hospitalized surgical patients develop surgical site infections. Wound infections lead to inflammation, tissue damage, and delayed healing, leading to prolonged hospital stays that impact healthcare costs. In the worst cases, the infection becomes aggressive and can progress to septic shock and death. [0003] Clinically, systemic (oral, intravenous) antibiotics and topical antimicrobials are currently used to treat wound infections. Systemic antibiotics have limited ...

Claims

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Application Information

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IPC IPC(8): A61L26/00C08J3/075C08L5/08C08L5/04
CPCA61L26/008A61L26/0095A61L26/0057A61L26/0066C08J3/075C08J2305/08C08J2305/04A61L2300/30C08L5/08C08L5/04
Inventor 史超杨发明胡乐王洪波王玉鑫陈景帝
Owner SHANDONG UNIV
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