Lycium barbarum polysaccharide with hypolipidemic effect

A technology of Lycium barbarum polysaccharide and Lycium barbarum, which is applied in the field of pharmaceutical chemistry, can solve the problems of unclear material basis and structure of hypolipidemic polysaccharide, wide molecular weight distribution, etc.

Active Publication Date: 2021-09-24
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the molecular weight distribution of polysaccharides from Lycium barbarum is very wide, and the material basis and structure of polysaccharides with hypolipidemic properties are still unclear.

Method used

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  • Lycium barbarum polysaccharide with hypolipidemic effect
  • Lycium barbarum polysaccharide with hypolipidemic effect
  • Lycium barbarum polysaccharide with hypolipidemic effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: Preparation of Lycium barbarum homogeneous polysaccharide LBP009-2-1 with hypolipidemic effect

[0027] 1. Preparation method of Lycium barbarum homogeneous polysaccharide LBP009-2-1

[0028] 1.1 Instruments, reagents and materials

[0029] DEAE-52 cellulose, Sephadex G-50, standard monosaccharides (arabinose, ribose, xylose, glucose, fructose, mannose, galactose, fucose, rhamnose, galactobionic acid, glucuronic acid and mannose sugar acid). All other chemicals were at least of analytical grade. The solvent for HPLC is chromatographically pure.

[0030] 1.2 Preparation of Lycium barbarum crude polysaccharide

[0031] figure 1 It is a flow chart of separating and purifying Lycium barbarum homogeneous polysaccharide LBP009-2-1 from Lycium barbarum.

[0032] Add 1L of distilled water to 100g of wolfberry, and use a high-speed shear dispersing and emulsifying machine to assist extraction, with a rotation speed of 15,000 rpm and an extraction temperature of ...

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Abstract

The invention provides a homogeneous polysaccharide of Lycium barbarum with good blood lipid-lowering effect. The water extract of Lycium barbarum is separated through membranes with molecular weights of 30, 10, and 5kDa respectively, and finally passes through a 10kDa membrane module and is separated by a 5kDa membrane module. The Lycium barbarum water extract component retained by the membrane module was freeze-dried, dissolved in distilled water, removed the protein, removed the pigment, and then dialyzed; the purified product was subjected to column chromatography and eluted with sodium chloride solution , collect the components, dialyze with a 1000Da dialysis bag, freeze-dry the dialysis product and dissolve it in distilled water again, further separate it with dextran gel, collect the components and freeze-dry to complete the preparation. The provided wolfberry polysaccharide has the effect of lowering blood fat, and can be used for preparing functional food, health food, food for special medical purpose or new medicine.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical chemistry, and in particular relates to a wolfberry polysaccharide with blood lipid-lowering effect. Background technique [0002] Hyperlipidemia refers to the abnormal increase of one or more lipids in plasma, mainly due to the increase of serum total cholesterol (TC), triglyceride (TG) or low-density lipoprotein cholesterol (LDL-c) levels, and abnormalities in lipid metabolism or transport. With the improvement of people's living standards and changes in diet structure, the number of patients with hyperlipidemia is increasing rapidly, and the age distribution is advancing. The number of young and middle-aged patients with hyperlipidemia has increased significantly. The occurrence of hyperlipidemia is a long process with little direct negative impact on the human body, but it can cause various complications, including atherosclerosis, coronary artery disease, cerebral infarction, cardiov...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B37/00A61P3/06
CPCA61P3/06C08B37/0003C08B37/006
Inventor 邸多隆刘建飞
Owner LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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