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Gel preparation containing hyaluronic acid, preparation method and application of gel preparation in endoscopy

A gel preparation and hyaluronic acid technology, applied in the field of biomedicine, can solve problems such as endoscopic lens blurring, achieve the effects of reducing mucous membrane inflammatory edema, improving hydrophilicity, and anesthesia speed and uniformity

Active Publication Date: 2021-06-01
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the patent still does not solve the problem that the endoscope lens is easily blurred in the body

Method used

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  • Gel preparation containing hyaluronic acid, preparation method and application of gel preparation in endoscopy
  • Gel preparation containing hyaluronic acid, preparation method and application of gel preparation in endoscopy

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preparation example Construction

[0048] The present invention also provides a preparation method of a gel preparation, characterized in that the method comprises the following steps:

[0049] adding hyaluronic acid or its salt, polyethylene glycol, and polyvinyl alcohol into water to swell to obtain a first solution;

[0050] adding ectoine, anesthetic, defoamer, and preservative into water to dissolve to obtain a second solution;

[0051] Add the second solution to the first solution, adjust the pH value to 5.5-7.0, and sterilize with moist heat to obtain a gel preparation.

[0052] In a specific embodiment, the hyaluronic acid or its salt is composed of oligomeric hyaluronic acid or its salt and cross-linked hyaluronic acid or its salt, wherein the molecular weight of the oligomeric hyaluronic acid or its salt is 1k-50kDa, for example, can be 1kDa, 2kDa, 5kDa, 10kDa, 20kDa, 30kDa, 40kDa, 50kDa, preferably 1k-10kDa. The cross-linked hyaluronic acid or its salt is obtained by cross-linking hyaluronic acid o...

Embodiment 1

[0058] (1) Preparation of cross-linked sodium hyaluronate

[0059] Dissolve 10g of sodium hyaluronate (Mw=1000kDa) in 100mL of 1wt% sodium hydroxide solution, add crosslinking agent BDDE, the amount of crosslinking agent is 4wt% of the mass of hyaluronic acid, mix well and crosslink in a water bath at 40°C 24h; after the reaction, adjust the pH value of the reaction solution to neutral; add an organic solvent or its aqueous solution under stirring to precipitate the reaction product in the form of microspheres, collect the precipitate, wash and dry the precipitate to obtain cross-linked sodium hyaluronate powder, The degree of crosslinking was 3.1%.

[0060] (2) Gel preparation preparation

[0061] Add 2g of cross-linked sodium hyaluronate prepared in step (1), 1g of oligomeric hyaluronate (Mw=5kDa), 15g of polyethylene glycol-2000 (PEG-2000), and 10g of polyvinyl alcohol into water, and Swell under stirring for 20min to obtain the first solution; add 3g of ectoine, 1g of li...

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Abstract

The invention provides a gel preparation, which is characterized in that the gel preparation comprises hyaluronic acid or a salt thereof, ectoine, polyethylene glycol, polyvinyl alcohol, an anesthetic and a defoaming agent. The gel preparation contains the hyaluronic acid and the Ectoine, the gel preparation is applied to endoscopy, the lubrication degree of an endoscope can be improved, it is guaranteed that the endoscope smoothly enters a body, the hyaluronic acid and the Ectoine are applied in a compounded mode, polyethylene glycol and polyvinyl alcohol are matched, the hydrophilic performance of gel is improved, a lens is effectively prevented from being contaminated by grease, and the cleanliness of the lens in the endoscopy process is ensured, so that the examination visual field is clear, and the disease diagnosis accuracy is greatly improved.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a hyaluronic acid-containing gel preparation, a preparation method and an application in endoscopic examination. Background technique [0002] Endoscope is an optical instrument, which is sent into the body from the outside through the natural cavity of the human body to inspect diseases in the body. It can directly observe the lesions in the inner cavity of the viscera, determine its location and range, and can take pictures, biopsy or brush. film, greatly improving the accuracy of disease diagnosis, and certain treatments can be performed. Endoscopy is now widely used, such as gastroscopy, colonoscopy, bronchoscopy, esophagoscopy, sigmoidoscopy, cystoscopy, laryngoscopy, nasopharyngoscopy, colposcopy and so on. [0003] Since the endoscope needs to be sent into the body from the outside through the natural cavity of the human body, it needs to be inserted smoothly, less ...

Claims

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Application Information

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IPC IPC(8): A61L31/06A61L31/04A61L31/14A61L31/16
CPCA61L31/042A61L31/06A61L31/048A61L31/145A61L31/16A61L2300/204A61L2300/216A61L2300/402C08L5/08C08L71/02C08L29/04
Inventor 耿凤邵萌王静郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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