Application of urine fibrinogen alpha-chain protein and polypeptide fragment thereof in normal pregnancy

Abstract

The invention provides an application of a urine fibrinogen alpha chain (FGA) protein and a polypeptide fragment thereof, and particularly relates to an application of the urine FGA protein and the polypeptide fragment thereof in the production of a preparation for monitoring normal pregnancy. Researches prove that compared with a normal childbearing age woman group (normal control), the expression of the FGA protein and the polypeptide fragment thereof in a normal pregnancy group is increased, and the FGA protein and the polypeptide fragment thereof can be used for monitoring the pregnancy state. According to the invention, the advantages of noninvasive acquisition, large-scale repeated sampling and convenient preservation of a urine sample are exerted, and the urine FGA protein and the polypeptide fragment thereof are detected by using the urine sample.

Description

technical field

[0001] The invention relates to a new application of urinary fibrinogen alpha chain (FGA) protein and its polypeptide fragment, in particular to the application of urinary FGA protein and its polypeptide fragment in monitoring normal pregnancy. Background technique

[0002] During pregnancy, in order to meet the needs of fetal growth and development, a series of changes will occur in the reproductive, blood circulation, urinary, respiratory, digestive and endocrine systems of pregnant women, especially in the endocrine system, the secretion of gonadotropins decreases, prolactin, thyroid stimulating hormone, etc. And the secretion of adrenocorticotropic hormone, glucocorticoid, aldosterone, and thyroid hormone increases. In the second and third trimesters of pregnancy, some pregnant women are less sensitive to insulin, which decomposes and antagonizes insulin and reduces insulin activity. Pregnant women cannot normally compensate for this physiological change ...

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