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Bioactive microcrystalline glass, preparation method and application thereof

A glass-ceramic and biologically active technology, applied in glass manufacturing equipment, glass furnace equipment, manufacturing tools, etc., can solve the problems of bone tissue elastic modulus mismatch, poor fracture healing effect, and obvious stress shielding effect, etc., to achieve Improve self-surface repair ability, enhance osteogenic activity, and excellent biological activity

Active Publication Date: 2021-06-18
北京纳通医学研究院有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Metal orthopedic implants have the advantages of high mechanical strength and good biocompatibility. However, there are problems such as too high relative bone density and too high strength, resulting in obvious stress shielding effect, so that the fracture site cannot be effectively stimulated by stress. Poor fracture healing
The inorganic materials currently used are mainly bioactive glass, which does not match the elastic modulus of bone tissue, which is likely to cause stress shielding problems, and has low mechanical strength, high brittleness, and insufficient repair ability.

Method used

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  • Bioactive microcrystalline glass, preparation method and application thereof
  • Bioactive microcrystalline glass, preparation method and application thereof
  • Bioactive microcrystalline glass, preparation method and application thereof

Examples

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preparation example Construction

[0037] The embodiment of the present invention also provides a method for preparing bioactive glass-ceramics, which includes the following steps:

[0038] a. The raw materials are ball milled in water according to the designed ratio, and the ball milling time is preferably 20min-50min, followed by drying treatment, preferably at a drying temperature of 60°C-120°C;

[0039] b. melting the dried raw materials in the step a using a two-stage heating program, pouring to form glass, and annealing;

[0040] c. Performing crystallization treatment on the glass annealed in step b.

[0041] According to the preparation method of bioactive glass-ceramics in the embodiment of the present invention, the raw materials are subjected to high-energy ball milling in water, and the melting temperature of glass raw materials can be lowered by 20-30°C by ball milling and mixing in medium water, so that the subsequent melting treatment can be performed at a higher temperature. It is completed und...

Embodiment 1

[0047] According to the design ratio in Table 1, the corresponding raw materials were mixed by high-energy ball milling in water for 30 minutes. The specific raw materials are: SiO 2 , Al(OH) 3 , SrCO 3 、LiCO 3 , CaCO 3 、K 2 CO 3 , (NH 4 ) 2 HPO 4 、H 3 BO 3 , ZrO 2 and colorant, the mixed raw materials are dried at 100°C. Put the dried raw materials into a silica crucible. The high-temperature furnace adopts a two-stage heating program. The first stage is kept at 900°C for 50 minutes to remove residual moisture in the raw materials and reduce the generation of air bubbles in the glass. Then raise the temperature to 1420°C and keep it warm for 40 minutes, so that the raw materials are completely in a homogeneous molten state. After being clarified at a high temperature, pour them into a mold to form a transparent glass. The glass is annealed in the annealing furnace, the annealing temperature is 550°C, the temperature is kept for 15 minutes, and the temperature is l...

Embodiment 2-5

[0051] The method is the same as in Example 1, except that the designed ratio of the glass-ceramics is different. The components and properties of the prepared glass-ceramics are shown in Table 1.

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Abstract

The invention discloses bioactive microcrystalline glass, which comprises a primary crystalline phase and a secondary crystalline phase, wherein the primary crystalline phase is lithium disilicate and / or lithium silicate, the secondary crystalline phase comprises strontium phosphate, the microcrystalline glass comprises the following components in percentage by mass: 50%-73% of SiO2, 0.2%-2% of Al2O3, 0.5%-5% of P2O5, 20%-30% of Li2O, 0.2%-6% of SrO, 0.5%-2.5% of ZrO2, 1.0%-3.5% of B2O3, 0.3%-3% of CaO and 2%-10% of K2O, the mass content of the primary crystalline phase in the microcrystalline glass is not less than 50%, and the mass content of the secondary crystalline phase is 3-12%. The bioactive glass ceramic disclosed by the invention is good in osteogenesis activity, has a surface self-repairing function, keeps good mechanical properties, and can be used for orthopedic implantation and dental restoration.

Description

technical field [0001] The invention belongs to the technical field of glass-ceramic materials, and in particular relates to a bioactive glass-ceramic, and further relates to a preparation method of the bioactive glass-ceramic, in particular, the present invention also relates to an application of the bioactive glass-ceramic . Background technique [0002] Human bones, teeth and other hard tissues need to be repaired or corrected with artificial materials when defects are caused by disease, trauma or deformity. Due to the excellent mechanical properties and ease of processing of metals, metal fixing materials such as stainless steel and titanium alloys are often used to make fixing devices. However, there is a risk of long-term slow release of metal ions to cause cancer, and while carrying metal implants, patients cannot undergo normal MRI examinations. The mechanical properties of metal implant materials are different from those of natural bone, and the elastic modulus is...

Claims

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Application Information

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IPC IPC(8): C03C10/10C03B1/00C03B5/16C03B25/00C03B32/02
CPCC03C10/0009C03B1/00C03B5/16C03B25/00C03B32/02
Inventor 廖运茂李梅李祥瑞董骧
Owner 北京纳通医学研究院有限公司