Nano radiotherapy sensitizer for reducing tumor radiation resistance and preparation method and application thereof
A radiotherapy and nanoparticle technology, which is applied in the field of tumor radiotherapy, can solve the problems of reducing the oxygen content of the tumor site, the impact of radiotherapy killing effect, and insufficient hydrogen peroxide content, so as to increase the local radiation dose, improve the ability of radiotherapy sensitization, reduce the Effects of Radiation Resistance
Active Publication Date: 2021-06-25
NANKAI UNIV
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However, although the above methods alleviate the hypoxic state of the tumor site to a certain extent, the oxygen carrier will inevitably leak oxygen during the blood circulation, thereby reducing the oxygen content delivered to the tumor site and affecting the hypoxic state of the tumor site. degree of relief
[0004] Although there have been studies on catalyzing the in situ decomposition of hydrogen peroxide in tumor cells to generate oxygen, as a raw material for catalytic oxygen production, there is still the problem of insufficient hydrogen peroxide content in tumor cells
In addition, reducing substances in tumor cells still have a great influence on the killing effect of radiotherapy
Method used
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Embodiment 1
[0055] The preparation method of Pt@HSA / CA nanoparticles comprises the following steps:
[0056] 1) Preparation of Pt@HSA nanoparticles: 500 mg of human serum albumin (HSA) was completely dissolved in 10 mL of ultrapure water, and 6 mL of 8 mg / mL chloroplatinic acid solution was added to the HSA solution under stirring conditions, and then The mixed solution was stirred under an 80° C. oil bath, and reacted for 2 hours. After the reaction, it was cooled to room temperature, transferred to a 50mL 30kDa ultrafiltration tube and centrifuged to remove unreacted reagents, the filtrate was removed and diluted with ultrapure water, and repeated 3 times. Then add ultrapure water to dilute it to 10mL for later use;
[0057] 2) Preparation of Pt@HSA / CA: Dissolve 2 μL cinnamaldehyde (CA) in 100 μL acetone, slowly add it into 10 mL 2.5 mg / mL Pt@HSA solution under stirring condition, and stir at room temperature for 24 hours. The reaction solution was dialyzed against pH 7.4 PBS buffer f...
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Abstract
The invention discloses a nano radiotherapy sensitizer for reducing tumor radiation resistance and a preparation method and application thereof. The nano radiotherapy sensitizer comprises Pt particles, human serum albumin (HSA) and cinnamyl aldehyde (CA), wherein the human serum albumin is respectively bonded with the Pt particles and the cinnamyl aldehyde. According to a Pt-coated HSA / CA nano material system disclosed by the invention, cinnamyl aldehyde is combined with HSA through a group-C=N-, so that cinnamyl aldehyde can be protected in a blood circulation process, is delivered to a tumor site and is released in a slightly acidic environment to induce oxidative stress, thereby providing additional hydrogen peroxide for platinum catalytic reaction to relieve hypoxia of tumor cells, and neutralizing reducing substances. Therefore, the radiation resistance of the tumor can be synergistically reduced through two ways, so that the radiotherapy sensitization capability of the high atomic number element platinum nano-cluster is synergistically improved.
Description
[0001] This application claims to enjoy the Chinese invention filed by the applicant with the application number 202110033309.0 to the State Intellectual Property Office on January 11, 2021, and the name is "a nano-radiotherapy sensitizer for reducing tumor radiation resistance and its preparation method and application" Priority of earlier patent applications. The entirety of this prior application is incorporated herein by reference. technical field [0002] The invention relates to the technical field of tumor radiotherapy, in particular to a nano-radiotherapy sensitizer for reducing tumor radiation resistance, a preparation method and application thereof. Background technique [0003] Radiation therapy ("radiotherapy") is a mainstay of conventional oncology treatment regimens and plays an important role in cancer treatment. It has been reported that more than 50% of cancer patients are treated with radiotherapy or a combination of radiotherapy and other therapies. Howe...
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Login to view more IPC IPC(8): A61K33/243A61K9/00A61K47/64A61K41/00A61P35/00A61P39/06B82Y5/00B82Y40/00A61K31/11
CPCA61K31/11A61K33/243A61K47/643A61P35/00A61P39/06B82Y5/00B82Y40/00A61K41/0038A61K9/0009A61K2300/00
Inventor 袁直余立诚王蔚
Owner NANKAI UNIV
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