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Quality detection method of compound radix zanthoxyli lozenge

A quality inspection method and technology of liangianzheng, which are applied in the directions of measuring devices, instruments, scientific instruments, etc., can solve the problems of restricting the quality control method of compound liangianzheng lozenges, unfavorable product quality monitoring, difficulty in establishing detection methods, etc., and achieve good quality. Controlled effect, reduced removal of coating, simple and convenient preparation method

Pending Publication Date: 2021-06-29
广西壮族自治区花红药业集团股份公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Compound Liangmianzhen buccal tablets have complex components of traditional Chinese medicine, and more sucrose is used in the raw materials of the preparation, which makes it difficult to establish the detection method. In the detection of high performance liquid chromatography and thin layer chromatography, it is easy to interfere with the detection results, resulting in Unstable test results limit the establishment of quality control methods for compound LMZ buccal tablets, which is not conducive to product quality monitoring

Method used

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  • Quality detection method of compound radix zanthoxyli lozenge
  • Quality detection method of compound radix zanthoxyli lozenge
  • Quality detection method of compound radix zanthoxyli lozenge

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The compound two-sided needle contains the detection of Siqiuqing fruit in the form of no food acid as a quality control indicator, and high performance liquid chromatography is detected, and the chromatographic conditions are:

[0043] Columns: octadecyl silicone bile silica gel is filler;

[0044] Test wavelength: 220 nm;

[0045] Mobile phase: The flow phase A is a 0.1 %% phosphoric acid solution containing sodium phyphoside, and the mobile phase B is acetonitrile - anhydrous ethanol-3% phosphate solution = 75: 9: 6, using gradient elution, mobile phase The proportion is the percentage of volume, the elution procedure is as follows:

[0046]0-3min, flow phase A is 94%, mobile phase B is 6%;

[0047] 3-10min, mobile phase A is 94% → 88%, mobile phase B is 6% → 12%;

[0048] 10-35min, mobile phase A is 88% → 58%, mobile phase B is 12% → 42%.

[0049] The method of preparing the test solution of the non-eyeic acid detected, including the step of: taking a food-free acid to ...

Embodiment 2

[0052] The compound two-sided needle contains the detection of Siqiuqing fruit in the form of no food acid as a quality control indicator, and high performance liquid chromatography is detected, and the chromatographic conditions are:

[0053] Columns: octadecyl silicone bile silica gel is filler;

[0054] Test wavelength: 220 nm;

[0055] Mobile phase: The flow phase A is a 0.4% phosphate solution containing 40 mmol / L containing phosphate, and the mobile phase B is acetonitrile - anhydrous ethanol-3% phosphate solution = 85: 15: 10, using gradient elution, flow ratio All are the percentage of volume, the elution procedures are as follows:

[0056] 0-3min, flow phase A is 94%, mobile phase B is 6%;

[0057] 3-10min, mobile phase A is 94% → 88%, mobile phase B is 6% → 12%;

[0058] 10-35min, mobile phase A is 88% → 58%, mobile phase B is 12% → 42%.

[0059] The method of preparing the test solution of the non-eyeic acid detected, including the step of: taking a food-free acid to ...

Embodiment 3

[0062] The compound two-sided needle contains the detection of Siqiuqing fruit in the form of no food acid as a quality control indicator, and high performance liquid chromatography is detected, and the chromatographic conditions are:

[0063] Columns: octadecyl silicone bile silica gel is filler;

[0064] Test wavelength: 220 nm;

[0065] Mobile phase: The flow phase A is a 0.2% phosphoric acid solution containing phosphate hydrogen phosphate, and the mobile phase B is acetonitrile - anhydrous ethanol-3% phosphoric acid solution = 82: 10: 8, using gradient elution, The flow phase proportion is a percentage of volume. The elution procedure is as follows:

[0066] 0-3min, flow phase A is 94%, mobile phase B is 6%;

[0067] 3-10min, mobile phase A is 94% → 88%, mobile phase B is 6% → 12%;

[0068] 10-35min, mobile phase A is 88% → 58%, mobile phase B is 12% → 42%.

[0069] The method of preparing the test solution of the non-eyeic acid detected, including the step of: taking a food-...

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Abstract

The invention discloses a quality detection method of a compound radix zanthoxyli lozenge. The quality detection method is characterized in that gallic acid is used as a quality control index in the detection of fructus chebulae immaturus, high performance liquid chromatography is adopted for detection, and the chromatographic conditions are as follows: octadecylsilane chemically bonded silica is used as a filler in a chromatographic column; the detection wavelength is 220 nm; mobile phases are as follows: a mobile phase A is a 0.1%-0.4% phosphoric acid solution containing 20-40 mmol / L of sodium dihydrogen phosphate, a mobile phase B is an acetonitrile-absolute ethyl alcohol-3% phosphoric acid solution in a ratio of (75-85):(9-15):(6-10), gradient elution is adopted, the mobile phase proportion is volume percent, and the elution procedure is that: in 0-3 minutes, the mobile phase A is 94%, and the mobile phase B is 6%; in 3-10 minutes, the mobile phase A is changed from 94 to 88%, and the mobile phase B is changed from 6% to 12%; and in 10-35 min, the mobile phase A is changed from 88% to 58%, and the mobile phase B is changed from 12% to 42%. The quality detection method disclosed by the invention is convenient to operate, accurate in detection result, good in stability and very high in practicability.

Description

Technical field [0001] The present invention relates to the field of mass detection methods of Chinese-tuned drugs, and more particularly to a mass detection method of compound two-sided needle containing sheet. Background technique [0002] Compound two-sided needle contains the exclusive products of Huahong Pharmaceutical Co., Ltd., Guangxi Zhuang Autonomous Region, which consists of Western Youth Fruit, Butterfly, Soybean Roots, Mint Oil, Mint Brain, Two-Side Needs, and Licorice. It has the effect of clearing and detoxifying, spindle hydrolysis. Throewang swellings caused by treatment in the temperature of the pulmonary heat. [0003] Compound two-sided needle tablets were complex because of the composition of the Chinese medicine itself, and more sucrose was used in the formulation raw materials, which makes it difficult to detect, high-performance liquid chromatography and thin layer chromatographic detection, which is prone to detect results. The detection result is unstabl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/34G01N30/90G01N30/94
CPCG01N30/02G01N30/06G01N30/34G01N30/90G01N30/94G01N2030/047Y02A50/30
Inventor 韦飞燕孙国祥张艳华刘春明庞宇张伟
Owner 广西壮族自治区花红药业集团股份公司
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