Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of hydrogenated styrene thermoplastic elastomers in preparation of artificial heart valves

A thermoplastic elastomer, artificial heart valve technology, applied in the field of biomedical materials, to achieve excellent biological stability, stable performance and quality control, and reduce costs.

Active Publication Date: 2021-07-16
SICHUAN UNIV +1
View PDF14 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these applications also involve human implantation, they are limited to within 30 days, and there is no long-term implantation in the human body.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of hydrogenated styrene thermoplastic elastomers in preparation of artificial heart valves
  • Application of hydrogenated styrene thermoplastic elastomers in preparation of artificial heart valves
  • Application of hydrogenated styrene thermoplastic elastomers in preparation of artificial heart valves

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A hydrogenation type styrenic elastomer (sample number is HW009), its styrene content is 42%, and its molecular structure is as follows:

[0035]

[0036] Then it was placed in a mold with a thickness of 0.1mm, and molded at 240° C. for 30 minutes to prepare the polymer valve.

Embodiment 2

[0038] A hydrogenation type styrene elastomer (sample number is HW010), its styrene content is 58%, and its molecular structure is as follows:

[0039]

[0040] Then it was placed in a mold with a thickness of 0.1mm, and molded at 240° C. for 30 minutes to prepare the polymer valve.

Embodiment 3

[0041] Example 3: In Vitro Accelerated Test of Biostability

[0042] An accelerated in vitro test of biostability is to place the sample in boiling concentrated nitric acid (65%), because nitric acid is not only a strong acid but also a strong oxidant [US Patent US 6102939]. For the sake of experimental safety, the test temperature of this example is room temperature, and the sample and concentrated nitric acid are mixed for 6 hours by a Teflon-coated rotor and a magnetic stirrer (unless otherwise specified).

[0043] The elastic material prepared in Example 2 of the present invention was tested for biological stability together with other elastic materials and biological valves, and the test results are shown in Table 1.

[0044] From the test results in Table 1, it can be seen that the biological valve material (pig pericardium) will curl up and change color in concentrated nitric acid, and form many tiny depressions on the surface while the strength is greatly reduced; poly...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Thicknessaaaaaaaaaa
Thicknessaaaaaaaaaa
Login to View More

Abstract

The invention discloses an application of hydrogenated styrene thermoplastic elastomers in preparation of artificial heart valves. The thermoplastic elastomers are a block polymer synthesized through active anionic polymerization, a solid phase or a dispersed phase is polystyrene, and a rubber phase is a hydrogenated conjugated diene polymer or a hydrogenated conjugated diene and styrene random copolymer. The hydrogenated styrene elastomers used in the invention have excellent biological stability, anti-coagulation performance, anti-calcification performance and mechanical strength, and can be used for preparing the artificial heart valves with more durable performance than that of a bioprosthetic valve.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to the application of a hydrogenated styrene thermoplastic elastomer in the preparation of artificial heart valves. Background technique [0002] Heart valve refers to the valve between the atrium and ventricle or between the ventricle and the artery, including the mitral valve between the left ventricle and left atrium, the tricuspid valve between the right ventricle and right atrium, and the aortic valve at the outlet of the left ventricle and the pulmonary valve at the outlet of the right ventricle. When the structure or function of the heart valve changes, the blood cannot be discharged smoothly, or the discharged blood flows back backwards, which increases the load on the heart. A series of diseases caused by this are called valvular heart disease. There are many causes of valvular heart disease, mainly rheumatic and degenerative. Rheumatic valvular h...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/16A61L27/50A61F2/24
CPCA61L27/16A61L27/50A61L2430/20A61L2400/16C08L25/06
Inventor 王云兵雷洋杨立周永华
Owner SICHUAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com