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Preparation method of artificial blood vessel and its application

An artificial blood vessel, monohydric alcohol technology, applied in the field of preparation and application of artificial organs, can solve the problems of easy thrombosis, no biological activity and anticoagulation activity, etc., and achieve excellent biocompatibility and biological stability, excellent blood phase. Capacitive, good compliance effect

Inactive Publication Date: 2008-10-15
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, polyester and expanded polytetrafluoroethylene have no biological activity and anticoagulant activity, and thrombosis is prone to occur after transplantation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Formulated according to the following components and compositions: PVDF 15%; PES 3%; DMAc 82%. Put the above raw materials into the dissolver, under the temperature control of 40-80°C, swell and dissolve to make a casting solution, and the casting solution is filtered and defoamed before use. The casting liquid is spun into a hollow fiber membrane through a concentric circular tube spinneret. The membrane forming process is as follows: the metering pump specification is 0.35ml / r, the pump speed is 4.5r / min, the length of the air section is 150mm, and the inner and outer coagulation baths are water. Wire speed 26m / min. The artificial blood vessel can be obtained by washing with water, preserving pores, drying at low temperature and coiling. The longitudinal shrinkage rate of the artificial blood vessel is 25%, and the water flux is 500L / m 2 .h, the retention rate of bovine serum albumin is 65%.

Embodiment 2

[0027] Batching according to the following components and composition: PVDF 18%; PS 5%; DMAc 77%. After dissolving the above raw materials according to the method of Example 1 and spinning, the longitudinal contraction rate of the artificial blood vessel is 21%, and the water flux is 210L / m 2 .h, the retention rate of bovine serum albumin is 70%.

Embodiment 3

[0029] Formulated according to the following components and composition: PVDF 20%; PES 3%; PS 3%; DMAc 74%. After dissolving the above raw materials according to the method of Example 1 and spinning, the longitudinal contraction rate of the artificial blood vessel is 18%, and the water flux is 180L / m 2 .h, the retention rate of bovine serum albumin is 78%.

[0030] The artificial blood vessels of the above-mentioned Examples 1, 2, and 3 were tested for performance, and the results are shown in the following table.

[0031] artificial blood vessel

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Abstract

The invention relates to a method for preparing an artificial vessel and the application thereof. The preparation method comprises the following steps: (1) in the preparation of membrane liquid, polymer that is 7 to 30 percent by weight proportion is added into organic solvent the weight proportion of which is 70 to 93 percent, so that casting solution is obtained through swelling and solution under the temperature between 40 DEG C and 80 DEG C; (2) in the preparation of the artificial vessel, a hollow fibre membrane is formed through the filtration and deaeration of the membrane liquid, serosity is squeezed out from a spinneret composed of two concentric tubes, the serosity which enters into precipitating bath through dry spinning then is processed through a post treatment process to obtain the artificial vessel. The method includes the application that the artificial vessel is transplanted to a physical organ or any organs which need quantities of vascular tissues to transport aliment, gas and waste. The artificial vessel obtained by using the preparation method has good adaptability, penetrability and biocompatibility, matches the self vessels, and has controllable outside diameter and wall thickness of the materials.

Description

technical field [0001] The invention belongs to the field of preparation and application of artificial organs, in particular to a preparation method and application of artificial blood vessels. Background technique [0002] Currently clinically used artificial blood vessels made of synthetic polymers mainly include polyethylene terephthalate (PET), expanded polytetrafluoroethylene (ePTFE) and polyurethane (PU). Polyethylene terephthalate is mainly woven into a tubular shape in the form of polyester fibers, and there are pores between the fibers for the growth of endothelial cells; the artificial blood vessel wall made of expanded polytetrafluoroethylene has a porous network structure, which is beneficial to endothelial cells. growth. However, polyester and expanded polytetrafluoroethylene have no biological activity and anticoagulant activity, and thrombosis is prone to occur after transplantation. Polyurethane has good biocompatibility and hemocompatibility, and can effec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/16A61L27/50D01D5/24D04H3/14A61F2/06
Inventor 孙俊芬何春菊王庆瑞陈雪英
Owner DONGHUA UNIV
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