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HIFU low-temperature focusing method, device and system

A focusing method and equipment technology, applied in ultrasonic therapy, treatment, medical science, etc., can solve problems such as damage and easy burns, and achieve the effects of expanding indications, preventing high-temperature damage, and avoiding thermal damage

Active Publication Date: 2021-07-20
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For nodules smaller than 2mm, when HIFU is used for treatment, the focal point is likely to cover the surrounding thyroid tissue and adjacent important tissues and organs, which is easy to burn and cause unnecessary damage

Method used

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  • HIFU low-temperature focusing method, device and system
  • HIFU low-temperature focusing method, device and system
  • HIFU low-temperature focusing method, device and system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 HIFU system and method for treating thyroid nodules with a maximum diameter greater than or equal to 2 mm

[0043] The system of this embodiment includes computer equipment and HIFU equipment, and the HIFU equipment can be realized with reference to the prior art.

[0044] The computer equipment is used to control the HIFU equipment, including a memory, a processor and a computer program stored on the memory and operable on the processor, and the processor implements the following steps when executing the program, including:

[0045] 1. Ultrasound guidance shows the location and size of the nodule to be treated, and defines the target area;

[0046] 2. The size of the lesion is 0.8×2×0.5mm. After ensuring that the lesion is located in the target area, at least fifteen HIFU focused ablations are performed on the target area, and the ablation temperature for each HIFU focused ablation is set at 44-45°C. The pulse parameters of focused ablation were pulse interv...

Embodiment 2

[0048] Example 2 HIFU system and method for treating thyroid nodules with a maximum diameter greater than or equal to 0.5 mm

[0049] The system of this embodiment includes computer equipment and HIFU equipment, and the HIFU equipment can be realized with reference to the prior art.

[0050] The computer equipment is used to control the HIFU equipment, including a memory, a processor and a computer program stored on the memory and operable on the processor, and the processor implements the following steps when executing the program, such as figure 2 shown, including:

[0051] 1. Ultrasound guidance shows the location and size of the nodule to be treated, and clearly defines the ablation target;

[0052] 2. Calculate the position coordinates of the center point of the nodule as the target ablation point;

[0053] 3. Perform rotational focus ablation on the target ablation point;

[0054] The specific process of the rotating focused ablation is as follows: rotate the probe o...

experiment example 1

[0059] Experimental example 1 animal muscle ablation experiment

[0060] This experimental example is carried out using the method of Example 2, and the HIFU equipment adopts the HIFU-2001 model.

[0061] experimental method:

[0062] 1. Preliminary experiment: Adjust the machine parameters so that the HIFU focus core depth is reduced to 45°C, and the focus area is as small as possible and the focus position is similar to the depth of the human thyroid gland. Specific parameter settings: the radius of curvature of the transducer is 38mm, the edge distance is 24mm, the sound frequency is 3MHz, the power is 70W, the size of the focal spot is 0.8×0.5×2mm, the temperature of the focal spot is adjusted to 45°C through the cooler, and the striking time of each pulse is 0.1s. The strike interval is 0.1s, and the strikes are rotated 15 times in each semicircular plane.

[0063] 2. Selection of experimental animals: male, 1.5-2.5Kg, 10 adult Chinese white rabbits.

[0064] 3. Specif...

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Abstract

The invention belongs to the technical field of medical equipment, and particularly relates to a low-temperature rotary focusing method, equipment and system for an HIFU ablation nodule. According to the focusing method, at least fifteen times of HIFU focusing ablation are carried out on a target area, and the ablation temperature of each time of HIFU focusing ablation is set to be 44 to 45 DEG C. In a preferable scheme, the focusing method comprises the following steps of: (1) displaying the position and the size of a nodule to be treated through ultrasonic guidance; (2) calculating a central point position coordinate of the nodule as a target ablation point; and (3) performing low-temperature rotary pulse ablation by taking the target ablation point as a vertex of a focal spot formed by HIFU focusing. The HIFU treatment system and method are higher in safety, precision and fineness, and have good application prospects in thermal ablation treatment of thyroid nodules, parathyroid nodules or neck lymph nodes.

Description

technical field [0001] The invention belongs to the technical field of medical equipment, and in particular relates to a HIFU low-temperature focusing method, equipment and system. Background technique [0002] In recent years, the detection rate of thyroid nodules in random population has increased year by year, reaching as high as 70%. Among the treatment methods for thyroid nodules, thermal ablation is gradually being applied clinically due to its advantages of less trauma and no surgical scar. [0003] The traditional thermal ablation technology is to puncture the nodule with an ablation needle, and the puncture needle uses radio frequency, microwave, laser and other methods to cause thermal coagulation and necrosis of nodular cells to achieve the purpose of treatment. High Intensity Focused Ultrasound (HIFU) eliminates the puncture step, and can directly penetrate the skin and accurately locate superficial tissues, so that the focused part releases heat energy, which a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B18/04A61N7/02
CPCA61B18/04A61N7/02A61B2018/00702
Inventor 赵婉君宋琳琳邢志超朱精强
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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