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PVP/PVB slow-release nanofiber medical dressing as well as preparation method and application thereof

A nanofiber, active substance technology, applied in the field of medicine, can solve the problems of poor strength, secondary damage, poor adhesion, etc., and achieve the effects of high strength, good air permeability, and good hydrophilicity

Active Publication Date: 2021-07-20
广州增城潮徽生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has the advantages of easy use, high strength of fiber membrane, and the gradual release of active ingredients of Periplaneta americana to the wound, which overcomes the shortcomings of general medical dressings such as poor applicability, easy to cause secondary injuries, and poor strength of general nanofiber medical dressings in water.

Method used

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  • PVP/PVB slow-release nanofiber medical dressing as well as preparation method and application thereof
  • PVP/PVB slow-release nanofiber medical dressing as well as preparation method and application thereof
  • PVP/PVB slow-release nanofiber medical dressing as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] A preparation method of Periplaneta americana slow-release nanofiber medical dressing, comprising the following steps:

[0034] (1) Weigh PVP2g and PVB10g with an electronic balance, put them into a clean Erlenmeyer flask, calculate the mass ratio of the solute to the solvent, and then add 100g of absolute ethanol into the Erlenmeyer flask at a temperature of 50°C After stirring in a water bath for 5 hours, wait for it to cool to room temperature, then add 10 g of Periplaneta americana Kangfuxin solution at room temperature and stir for 5 hours to prepare Periplaneta americana @PVP / PVB spinning solution. The spinning conditions were set as follows: injection speed 10.0mm / h, receiving distance 20cm, spinning voltage 23kV, using a single-needle electrospinning machine to prepare the Periplaneta americana@PVP / PVB nanofiber membrane.

[0035] Nanofibers with sustained release effect prepared by electrospinning figure 1 shown. Since Periplaneta americana Kangfuxin solution...

Embodiment 2

[0037] A preparation method of Periplaneta americana slow-release nanofiber medical dressing, comprising the following steps:

[0038] (1) Weigh an appropriate amount of PVP 2g and PVB 5g with an electronic balance, and the mass ratio of PVP to PVB is 2:5. After calculating the mass ratio of the solute to the solvent, add 60g of absolute ethanol into the Erlenmeyer flask, stir in a water bath at a temperature of 60°C for 5 hours, then add 5g of Periplaneta americana Kangxin solution at room temperature and stir again 4h, the Periplaneta americana @PVP / PVB spinning solution spinning solution was prepared. The spinning conditions were set as follows: injection speed 5.0mm / h, receiving distance 22cm, spinning voltage 25kV, using a single-needle electrospinning machine to prepare the Periplaneta americana@PVP / PVB spinning nanofiber membrane.

[0039] Since the Periplaneta americana Kangfuxin solution is a mixture, we selected phenylalanine as the calibration substance, put 0.01 g...

Embodiment 3

[0041] A preparation method of Periplaneta americana slow-release nanofiber medical dressing, comprising the following steps:

[0042](1) Weigh an appropriate amount of PVP 3g and PVB 5g with an electronic balance. After calculating the mass ratio of solute and solvent, add 60g of absolute ethanol into the Erlenmeyer flask, stir in a water bath at a temperature of 55°C for 6h, then add 10g of Periplaneta americana Kangxin solution at room temperature and stir for 5h , to prepare Periplaneta americana @PVP / PVB spinning solution. The spinning conditions were set as follows: injection speed 8.0mm / h, receiving distance 21cm, spinning voltage 24kV, using a single-needle electrospinning machine to prepare the Periplaneta americana@PVP / PVB nanofiber membrane.

[0043] Since the Periplaneta americana Kangfuxin solution is a mixture, we selected phenylalanine as the calibration substance, put 0.01 g of nanofiber membrane into the sample tube, and then injected 1mL of pure water to con...

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Abstract

The invention belongs to the technical field of medicines, and particularly discloses a PVP / PVB slow-release nanofiber medical dressing as well as a preparation method and application thereof. The preparation method of the PVP / PVB slow-release nanofiber medical dressing specifically comprises the following steps: mixing PVP and PVB with absolute ethyl alcohol, then adding an active substance, and continuously conducting mixing to prepare a spinning solution containing the active substance; then, conducting electrostatic spinning to prepare the PVP / PVB slow-release nanofiber medical dressing. The nanofiber medical dressing obtained by the invention not only has very good air permeability and very high porosity, but also can keep a wound moist so as to be beneficial to the respiration of cells. The nanofiber has the advantage that the nanofiber can effectively prevent bacteria and particles in the air from being in contact with the whole wound, and the nanofiber slow-release medical dressing prepared by blending PVP and PVB through spinning is very high in strength and is very suitable for being used as a membrane material of the medical dressing due to the fact that the characteristics of PVP are ingeniously utilized.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a PVP / PVB slow-release nanofiber medical dressing and a preparation method and application thereof. Background technique [0002] Traditional medical dressings are mainly prepared using absorbent cotton gauze as the base cloth, which is applied to the wound and adheres to the skin during the wound healing process. Changing the dressing will cause secondary damage to the wound and cause pain to the patient. The medical dressing film prepared by the coating method can be applied better than traditional cotton gauze, but it is airtight and cannot absorb skin exudate. The nanofiber membrane prepared by electrospinning technology has high porosity and good air permeability, which can not only keep the wound moist, but also facilitate the respiration of cells. On the other hand, the nanofiber membrane can filter out most of the bacteria and dust in the air to prevent the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/40A61L15/42A61L15/44A61L15/24D01F8/10D01F1/10
CPCA61L15/40A61L15/42A61L15/425A61L15/44A61L15/24D01F8/10D01F1/10A61L2300/602A61L2400/12C08L39/06C08L29/14
Inventor 程建华张继勇黄政
Owner 广州增城潮徽生物技术有限公司
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