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Preparation method of amino acid surfactant

A surfactant and amino acid technology, applied in the field of synthesis of fine chemical products, can solve the problems affecting the degree of reaction and reaction efficiency, harm to equipment and operators, and temperature rise of the reaction system, etc., and achieve good reaction efficiency, high safety, The effect of precise reaction temperature

Pending Publication Date: 2021-07-20
GUANGDONG HEJI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Synthetic products contain more soluble impurities, which affect the use of products in formulations
In industrial production, it is necessary to keep the sealing of equipment and pipelines. When acid chloride is added, a large amount of acid mist will be generated, a large amount of heat will be released, and the pressure in the kettle will increase, causing the temperature of the reaction system to rise rapidly, affecting the degree of reaction and reaction efficiency.
When the acyl chloride leaks, it will corrode the surface of the equipment tank, and the human body will inhale a large amount of acyl chloride, which can lead to poisoning and coma, which is harmful to the equipment and operators

Method used

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  • Preparation method of amino acid surfactant
  • Preparation method of amino acid surfactant
  • Preparation method of amino acid surfactant

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preparation example Construction

[0025] The preparation method of amino acid surfactant provided by the present invention, the method comprises: carry out contact reaction with the aqueous solution of fatty acid chloride and amino acid and / or amino acid salt in microchannel reactor, obtain amino acid surfactant; Wherein, the microchannel reactor The channel reactor includes a plurality of reaction sheets including microchannel structures.

[0026] In the present invention, the microchannel reactor can adopt any existing microchannel reactor that can be used for liquid phase reaction. Preferably, in order to fully contact and react the aqueous solution of fatty acid chloride and amino acid and / or amino acid salt, the microchannel reactor with the heart-shaped microchannel structure is used for preparation, preferably Corning's Advanced- Reactor G1. The microchannel structure of described heart-shaped structure can for example be image 3 As shown, the microchannel structure includes more than one (for examp...

Embodiment 1

[0039] Take 65g of L-glutamic acid powder, add 35g of sodium hydroxide to prepare a 20% by weight amino acid alkaline solution, and make the volume ratio of the solution to the lauroyl chloride solution (concentration: 98% by weight) 5.0:1. , the two solutions are passed into the microchannel reactor through the metering pump, the flow rate of the amino acid alkaline solution is 40mL / min, the flow rate of the lauroyl chloride solution is 8mL / min, the temperature of the reaction piece is 18°C, and the reaction pressure is 0.02MPa, The reaction time was 85s. After the reaction, the product flowed out from the outlet of the microchannel reactor to obtain the crude sodium lauroyl glutamate.

[0040] After diluting the above-mentioned crude product with pure water to an equal volume, purify by ultrafiltration (using an ultrafiltration membrane with a molecular weight cut-off of 200, the pressure is 10MPa, and the temperature is 20°C), and then concentrate under reduced pressure (the...

Embodiment 2

[0044] Get L-alanine powder 50g, after adding the sodium hydroxide of 22.5g and be mixed with the amino acid basic solution of 20% by weight, be 5.6:1 with the volume ratio of this solution and cocoyl chloride (concentration is 98% by weight) The method is to pass the two solutions into the microchannel reactor through the metering pump, the flow rate of the amino acid alkaline solution is 22.4mL / min, the flow rate of the cocoyl chloride solution is 4.2mL / min, and the temperature of the reaction plate is set at 20°C. The pressure is 0.02MPa, and the reaction time is 117.8s. After the reaction finishes, the product flows out from the outlet of the microchannel reactor to obtain the crude product of sodium cocoyl alanine.

[0045] After the above-mentioned crude product is diluted with pure water in equal volume, it is purified by ultrafiltration (using an ultrafiltration membrane with a molecular weight cut-off of 150, the pressure is 15MPa, and the temperature is 17° C.) and co...

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Abstract

The invention relates to the technical field of synthesis of fine chemical products, and discloses a preparation method of an amino acid surfactant. The method comprises the steps that fatty acyl chloride and an aqueous solution of amino acid and / or amino acid salt are subjected to a contact reaction in a micro-channel reactor, the amino acid surfactant is obtained, the micro-channel reactor comprises a plurality of reaction pieces, and each reaction piece comprises a micro-channel structure. According to the invention, a continuous operation mode is adopted, two streams of materials are respectively introduced into the micro-channel reactor by utilizing a pump, are preheated and then reach a reaction area for reaction, the materials flow out from an outlet of the micro-channel reactor after the reaction is finished to obtain a crude product, and the crude product is only subjected to membrane filtration and concentration purification treatment to obtain the high-purity amino acid surfactant.

Description

technical field [0001] The invention relates to the technical field of synthesis of fine chemical products, in particular to a continuous production and solvent-free purification process technology of an amino acid surfactant using a microchannel reactor. Background technique [0002] Amino acid surfactant is a kind of mild and degradable anionic surfactant. Because of its excellent foaming properties and rich foam, it is widely used in daily necessities such as shampoo, shower gel, facial cleansing products, toothpaste, etc. The pH of amino acid surfactants is close to that of human skin, mild and low irritation, soft skin feeling, and frequent use will not damage the skin, so it is more suitable for daily care products. At present, the content of chloride and fatty acid in amino acid surfactants is the key point that needs to be controlled in formulation application. Therefore, improving product purity and effectively removing soluble impurities in products is an important...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C231/02C07C233/47B01F17/22C09K23/22
CPCC07C231/02C07B2200/09C09K23/00C07C233/47
Inventor 何廷刚艾勇张炽坚江桦黎伟杰陆锦平卢永杰高标
Owner GUANGDONG HEJI BIOTECH CO LTD
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