Cellulose nanocrystal enhanced efficient self-healing hydrogel and preparation method thereof
A technology of nanocrystals and cellulose, applied in the field of high-efficiency self-healing hydrogels reinforced by cellulose nanocrystals and its preparation, can solve the problems of unsatisfactory biocompatibility and poor self-healing performance of hydrogels, etc. Achieve the effect of improving biocompatibility, high swelling performance and high water absorption rate
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[0042] The present invention also provides a method for preparing a highly efficient self-healing hydrogel reinforced by cellulose nanocrystals, comprising the following steps:
[0043] S1. Preparation of hydrazide-modified hyaluronic acid with disulfide bonds;
[0044] Take a certain amount of hyaluronic acid and dissolve it in deionized water to prepare a solution with a mass volume ratio of 1g:(20-200)ml, then add carbodiimide (EDC), activation auxiliary agent (NHS) and 3,3 '-Dithiodipropionyl hydrazide; Wherein, the mol ratio of hyaluronic acid and carbodiimide (EDC) is 1:(0.1~15), and the mol ratio of carbodiimide and activation auxiliary agent is 1:( 0.1~10), the molar ratio of hyaluronic acid and 3,3`-dithiodipropionyl hydrazide is 1:(1~15); after reacting at 25~50℃ for 1~24h, dialyze with deionized water 1 to 3 days, followed by freeze-drying at -50 to -80°C and 1 to 80 Pa to obtain hydrazide hyaluronic acid with a substitution degree of 0.1 to 0.8.
[0045] S2. Prep...
Embodiment 1
[0053] A highly efficient self-healing hydrogel reinforced by cellulose nanocrystals, prepared by the following steps:
[0054] S1. Preparation of hydrazide-modified hyaluronic acid with disulfide bonds
[0055] Dissolve a certain amount of hyaluronic acid in deionized water to form a solution with a mass volume ratio of 1g:100ml, and then add carbodiimide (EDC), activation auxiliary agent (NHS) and 3,3'-dithio Dipropionyl hydrazide; wherein, the molar ratio of hyaluronic acid and carbodiimide (EDC) is 1:0.5, the molar ratio of carbodiimide and activation auxiliary agent is 1:0.5, hyaluronic acid and 3,3` - The molar ratio of dithiodipropionyl hydrazide is 1:5; then react at 25-50°C for 1-24h, then dialyze with deionized water for 1-3d, then at -50-80°C, 1-80Pa Freeze-drying under certain conditions can obtain hydrazidated hyaluronic acid with a degree of substitution of about 0.5.
[0056] S2. Prepare a dispersion of cellulose nanocrystals with aldehyde groups at a mass con...
Embodiment 2-7 and comparative example 1
[0066] The high-efficiency self-healing hydrogel enhanced by cellulose nanocrystals provided in Examples 2-7 and Comparative Example 1, compared with Example 1, differs in that the formaldehyde-based cellulose nanocrystals prepared in step S2 The length and diameter are shown in Table 1. Others are substantially the same as in Embodiment 1, and will not be repeated here.
[0067] Preparation conditions and performance test results of Table 1 Embodiment 1-7 and Comparative Example 1
[0068]
[0069] It can be seen from Table 1 that with the increase of the aspect ratio, the water absorption of the hydrogel first increases and then decreases, and the strength first increases and then decreases, but the self-healing efficiency gradually decreases; with the increase of the overall size The strength of the hydrogel tends to decrease gradually, which may be the result of the joint determination of the content of aldehyde groups on the crystal surface and the crystal size. In a...
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