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Surface modification method of magnetic microspheres

A technology of surface modification and magnetic microspheres, which is applied in the field of polymer materials, can solve problems such as difficult uniformity and controllable surfaces, and achieve the effect of high uniformity and low leakage

Pending Publication Date: 2021-07-23
SUZHOU WEIDU BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The way and difficulty of surface modification with polymers are significantly different depending on the size of the magnetic microspheres: magnetic microspheres below the micron level can be directly polymerized by free radicals to form an obvious polymer shell on the surface to complete the surface modification, while For magnetic microspheres with a size of more than micron, especially tens to tens of microns, due to the large size of the microspheres, free radical polymerization in the presence of magnetic beads is easy to nucleate polymer microspheres outside the magnetic beads, rather than inside them. A polymer layer is formed on the surface, so it is difficult to form a uniform and controllable surface on the surface by free radical polymerization

Method used

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  • Surface modification method of magnetic microspheres

Examples

Experimental program
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Effect test

Embodiment 1

[0030] Weigh 1 g (15 μm) of polyethyleneimine-modified magnetic microspheres and disperse them in 200 g of deionized water, add 1 g of glycidyl methacrylate, 2 g of 1,4-butanediol diglycidyl ether, ethylene glycol di 1 g of methacrylate was reacted at 80° C. for 10 h, 40 g of sodium persulfate aqueous solution (1%) was added dropwise, and the reaction was continued for 12 h after the addition was completed. Washing with absolute ethanol and deionized water in sequence to obtain magnetic microspheres modified with epoxy groups on the surface.

Embodiment 2

[0032] Weigh 1g (25um) of polyethyleneimine-modified magnetic microspheres and disperse them in 200g of deionized water, add 1g of allyl glycidyl ether, 1.5g of ethylene glycol diglycidyl ether, ethylene glycol dimethacrylic acid 1g of ester was reacted at 70°C for 12h, 40g of sodium persulfate aqueous solution (1%) was added dropwise, and the reaction was continued for 10h after the addition was completed. Washing with absolute ethanol and deionized water in sequence to obtain magnetic microspheres modified with epoxy groups on the surface.

Embodiment 3

[0034] Weigh 1 g of the surface epoxy group-modified magnetic microspheres prepared in Example 2 and disperse them in 200 g of 0.1 M NaOH aqueous solution, stir at 75 ° C for 4 h, wash with deionized water until the supernatant is neutral, and dry to obtain magnetic microspheres. ball powder. Take 0.5g of the above magnetic microsphere powder and ultrasonically disperse it in 100g of N,N-dimethylformamide, add 0.1g of pyridine and 1g of succinic anhydride, stir at room temperature for 6h, and wash with absolute ethanol, 0.1M NaOH, and deionized water successively. Wash until the supernatant is neutral to obtain magnetic microspheres with carboxyl groups on the surface.

[0035] Depend on figure 1 It can be seen that the surface of the magnetic microspheres prepared in Example 1 is uniform and there is no aggregation of magnetic particles.

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Abstract

The invention relates to a surface modification method of magnetic microspheres, which comprises the following steps: dispersing magnetic microspheres with polyethyleneimine molecules modified on the surfaces, and adding epoxy monomers, diepoxide and a cross-linking agent; and then adding an initiator to obtain the magnetic microspheres with surfaces modified by the epoxide. The microspheres of 10-30 microns are modified through free radical polymerization, the formed polymer microspheres are high in surface uniformity, magnetism is not prone to leakage, and a foundation is provided for follow-up diversified application of the microspheres.

Description

technical field [0001] The invention relates to the technical field of polymer materials, in particular to a method for modifying the surface of magnetic microspheres. Background technique [0002] Magnetic microspheres are composite microspheres with certain magnetic properties and special structures formed by combining magnetic inorganic particles and organic polymers by appropriate methods. Magnetic composite microspheres not only have many characteristics of ordinary polymer microspheres but also have magnetic responsiveness, so not only can they be endowed with surface functional groups (such as -OH, -COOH, -CHO, -NH2, etc.), it can also have a guiding function under the action of an external magnetic field. [0003] Magnetic composite microspheres have been widely used in many fields such as biomedicine, cytology and separation engineering. The surface properties of magnetic microspheres are very important for applications. Surface modification with polymers has obvi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J7/16C08L25/06C08L33/12C08L33/14
CPCC08J7/16C08J2325/06C08J2333/12C08J2333/14C08J2479/02
Inventor 宋孟杰刘照关
Owner SUZHOU WEIDU BIOTECH CO LTD
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