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Mn (II) complex with AIE property and function of targeting living cell mitochondria as well as preparation method and application of Mn (II) complex

A living cell and mitochondrial technology, applied to organic compounds of group 7/17 without C-metal bonds, chemical instruments and methods, compounds of group 7/17 elements of the periodic table, etc., can solve the problem of short absorption wavelength and application prospects Limitations and other issues, to achieve the effect of long wavelength, strong penetration, low excitation energy

Pending Publication Date: 2021-08-03
ANHUI UNIVERSITY
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Problems solved by technology

[0003] However, due to the small multi-photon absorption cross-section and short absorption wavelength of most existing organic materials, the application prospects are limited, and the search for multi-photon absorption materials with large absorption cross-sections and long wavelengths has become a hot spot in the field of nonlinear optics, so the structure is diverse. , unique properties, and simple synthesis of multiphoton complexes have attracted extensive attention from researchers

Method used

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  • Mn (II) complex with AIE property and function of targeting living cell mitochondria as well as preparation method and application of Mn (II) complex
  • Mn (II) complex with AIE property and function of targeting living cell mitochondria as well as preparation method and application of Mn (II) complex
  • Mn (II) complex with AIE property and function of targeting living cell mitochondria as well as preparation method and application of Mn (II) complex

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Embodiment Construction

[0028] In order to make the technical means, creative features, goals and effects achieved by the present invention easy to understand, the present invention will be further elaborated below in conjunction with specific embodiments and illustrations.

[0029] 1. Preparation of Compound O

[0030] Under ice-salt bath conditions, weigh the refined DMF (4.38g, 0.06mol) in a 500mL round bottom flask, and drop POCl into it with a constant pressure dropping funnel. 3 (15.30g, 0.1mol), after the frozen salt is formed, weigh N,N-dibutylaniline (4.10g, 0.02mol), dissolve it with 50mL chloroform and pour it into the frozen salt, after the frozen salt melts, 65 Reflux at ℃ for 6h. After the reaction was complete, the reactant was poured into a large amount of ice water, the pH was adjusted to neutral with NaOH aqueous solution, extracted with dichloromethane, and the solvent was distilled off under normal pressure to obtain an oily liquid. The crude product was subjected to silica gel ...

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Abstract

The invention discloses a Mn (II) complex with AIE property and a function of targeting living cell mitochondria as well as a preparation method and application of the Mn (II) complex, and relates to the technical field of multiphoton absorption materials. The Mn (II) complex is called FD-MnCl2 for short, and the structural formula is shown in the specification. The novel terpyridyl Mn (II) complex synthesized by the invention is a multi-photon absorption material with a cell developing function. Compared with other materials, the complex has the characteristics of large three-photon absorption cross section, low excitation energy, long wavelength, strong penetrability, small light damage and the like. The complex can be used for multi-photon biological imaging, and has obvious application value.

Description

Technical field: [0001] The invention relates to the technical field of multiphoton absorption materials, in particular to a Mn(II) complex with AIE properties and the function of targeting the mitochondria of living cells, its preparation method and application. Background technique: [0002] Multiphoton absorption is a nonlinear optical effect. Under the irradiation of a high-intensity laser beam, a substance may absorb several or even dozens of photons at the same time, and this process is called multi-photon absorption. Compared with the traditional single-photon absorption, multi-photon absorption has obvious advantages in the fields of three-dimensional controllable, photolytic drug release, bioluminescent labeling, multiphoton fluorescence microscopy (MPFM), etc., thus attracting great interest of researchers. . [0003] However, due to the small multi-photon absorption cross-section and short absorption wavelength of most existing organic materials, the application...

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Application Information

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IPC IPC(8): C07F13/00C09K11/06G01N21/64
CPCC07F13/005C09K11/06G01N21/6458G01N21/6428G01N21/64G01N21/6402C09K2211/188G01N2021/6419G01N2021/6439Y02P20/55
Inventor 张琼蔡昌婷房成剑徐景方芝云宣俊田玉鹏
Owner ANHUI UNIVERSITY
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