Application of radix astragali extract

An extract of astragalus, technology of astragalus, applied in the field of use of astragalus extract, can solve problems such as photosensitivity, adverse reactions, nausea and vomiting, and achieve the effect of inhibiting pulmonary fibrosis, less toxic and side effects, and low price

Inactive Publication Date: 2021-08-10
LANZHOU UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These two drugs have shown good efficacy in numerous clinical trials, but they are not suitable for all patients with pulmonary fibrosis, and may cause adverse reactions of varying degrees, such as nintedanib can cause diarrhea, Adverse reactions such as nausea and vomiting, abdominal pain, loss of appetite, weight loss and elevated liver enzymes, pirfenidone can cause symptoms such as nausea and vomiting, photosensitivity, liver function damage and lethargy in patients
In addition, although the treatment of acute exacerbation

Method used

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  • Application of radix astragali extract
  • Application of radix astragali extract
  • Application of radix astragali extract

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Embodiment Construction

[0036] In order to understand the present invention, the present invention will be further described below in conjunction with specific examples.

[0037] 1. Animal grouping, model building and material collection

[0038] C57BL / 6 mice were randomly divided into blank control group, sham operation group, bleomycin model group, astragalus total flavonoids intervention group, and astragalus saponins intervention group, with 15 mice in each group. Intratracheal injection of bleomycin to establish a mouse model of pulmonary fibrosis. Specifically, mice were anesthetized by intraperitoneal injection of 0.1ml 4% chloral hydrate. After anesthesia, they were placed supine on the mouse platform, and the neck was disinfected with iodophor and alcohol to separate and expose the trachea layer by layer. Then slowly inject 0.05ml of bleomycin (5mg / kg body weight) or normal saline solution into the trachea. Immediately after the injection, the animal is upright and rotated left and right, s...

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Abstract

The invention relates to an application of an extract of a medicinal natural product, in particular to an application of a radix astragali extract. The natural product extract disclosed by the invention is an extract of radix astragali, especially total flavonoids of radix astragali or astragaloside. The radix astragali extract disclosed by the invention can be directly used for preparing the medicine for treating the pulmonary fibrosis disease or used for preparing the compound medicine for treating the pulmonary fibrosis disease. The invention has the following beneficial effects: 1, it is found for the first time that total flavonoids of radix astragali and astragaloside can inhibit polarization of M2 type macrophages and activation of TGF-beta1/Smads signal channels, and effectively inhibit pulmonary fibrosis; and 2, the medicine is a traditional Chinese medicinal material, is low in price and small in toxic and side effects, can remarkably inhibit the development of pulmonary fibrosis, and is worthy of wide popularization.

Description

technical field [0001] The present invention relates to the use of an extract of a medicinal natural product, specifically, the present invention relates to the use of an extract of Astragalus membranaceus. Background technique [0002] Astragalus membranaceus is a traditional Chinese medicinal material, which contains saponins, flavonoids, polysaccharides, trace elements and other components, and has anticancer, hepatoprotective, antibacterial and antiviral, antioxidative, anticonvulsant and neuroprotective effects. [0003] Pulmonary fibrosis is a chronic and progressive pulmonary interstitial disease. The main pathological changes are pulmonary inflammatory cell infiltration, abnormal deposition of cell matrix, and excessive proliferation of fibroblasts accompanied by alveolar structural destruction, and gradually lead to pulmonary ventilation. Function declines, and eventually most patients die of respiratory failure caused by diffuse pulmonary fibrosis. At present, it ...

Claims

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Application Information

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IPC IPC(8): A61K36/481A61P11/00
CPCA61K36/481A61P11/00
Inventor 张芳芳毛雪丽卢锦辉张丽侯皓中赵鹏飞郭琛魏静李敏张娜南晓娟
Owner LANZHOU UNIVERSITY
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