Gelatin-based low-temperature injection anti-inflammatory and antibacterial viscous hydrogel, preparation method and application thereof

Abstract

A gelatin-based low-temperature injection anti-inflammatory and antibacterial viscous hydrogel, a preparation method and application thereof. The hydrogel includes gelatin, hydroxyethyl urea and punicalagin. Using a one-pot mixing method, hydroxyethyl urea is added to the gelatin aqueous solution, and the hydrogen bond interaction between gelatin and hydroxyethyl urea is used to prevent the gelatin from cooling at low temperature. Self-gelation by forming hydrogen bonds to achieve low-temperature injection; then add punicalagin to utilize the strong hydrogen bond interaction between punicalagin and gelatin to form the main network. As a multifunctional wound adhesive, the hydrogel is stable in air, and the bonding strength reaches 45.77kPa within 10 minutes, and the bonding strength is still 40kPa after 14 days. The hydrogel has anti-inflammatory, antibacterial and obvious healing-promoting abilities for wounds, and realizes the integration of bonding function and biological function. The hydrogel is sealed in a syringe or hose, stored at low temperature, and directly used for surgical bonding or mucosal repair, or coated on a substrate, and its viscosity is stimulated by medical alcohol after drying, and used as daily abrasions.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a gelatin-based low-temperature injection anti-inflammatory and antibacterial viscous hydrogel whose viscosity is stimulated by medical alcohol, a preparation method and application thereof. Background technique [0002] In recent years, many emerging biomedical materials have been used for wound adhesion or wound protection, including porous sponges, electrospun membranes, biofilms, hydrogels, etc. Considering biocompatibility, most of them are gelatin-based. [0003] Based on the impact of the finished product form, the above-mentioned materials, except hydrogel, do not have injectable properties, and cannot be applied to minimally invasive or non-invasive surgery, which increases the risk of surgery. However, gelatin-based hydrogels often need to be stored at low temperatures, and the transportation cost is high, and they will form hydrogen bonds to form gels at l...

AI Technical Summary

Problems solved by technology

[0003] Based on the impact of the finished preparation, the above materials, except hydrogel, are not injectable, and cannot be applied to minimally invasive or non-invasive surgery, which increases the risk of surgery

However, gelatin-based hydrogels often need to be stored at low temperature, and the transportation cost is high, and it will form hydrogen bonds to form a gel at low temperature, and it needs to be heated to restore its injectability during application, which increases the time cost

[0004] In addition, it is difficult for the above materials to achieve the organic unity of the biological function and adhesive performance of the wound dressing. It is often necessary to use gauze or viscous paint to achieve adhesion to the wound, which increases the difficulty of operation.

[0005] In addition, gelatin-based materials are extremely prone to bacterial growth, so it is necessary to endow the material with antibacterial capabilities

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