A patch for repairing abdominal wall tissue and its preparation method

Abstract

The invention relates to an abdominal wall tissue repair patch and a preparation method thereof. The repair patch includes a growth layer and an insulation layer; the growth layer is a micro-nano fiber-hydrogel interpenetrating three-dimensional network composed of a micro-nano fiber three-dimensional network and a hydrogel , the insulating layer is a micro-nanofiber film; the average angle between the axial direction of the micro-nanofibers in the growth layer and the insulating layer and the longitudinal direction of the repair patch is 5°-30°; A self-locking three-dimensional network with more than 99% of the micro-nanofibers in a monodisperse state; the method is: firstly, the insulating layer is prepared by electrospinning, and the hydrogel precursor system is added while receiving the micro-nanofibers on the insulating layer Obtain a composite layer; then expand the hydrogel precursor to obtain a micro-nanofiber-hydrogel three-dimensional interpenetrating network abdominal wall tissue repair patch; the process of the method is simple and controllable; the mechanics of the present invention have good mechanical strength and force conduction performance And tensile fatigue resistance, can induce cells to align along the patch orientation under force stimulation.

Description

technical field [0001] The invention belongs to the technical field of tissue engineering, and relates to an abdominal wall tissue repair patch and a preparation method thereof, in particular to a micro-nano fiber-hydrogel three-dimensional interpenetrating network abdominal wall tissue repair patch and a preparation method thereof. Background technique [0002] Abdominal wall defect is a clinically common disease. When the abdominal wall defect is large, it is usually necessary to use implant materials to suture the abdominal wall defect to reduce the tension of the abdominal wall and speed up the wound repair of the patient. The implant materials currently used for the repair of abdominal wall defects can be divided into the following two types: synthetic mesh and biological mesh. [0003] Synthetic patches mainly include microporous membrane patches and mesh patches. Among them, the mesh patch is one of the common artificial patches due to its light weight and excellent...

AI Technical Summary

Problems solved by technology

However, the following problems still exist: 1. The mechanical compatibility is poor; 2. The degradation rate of decellularized tissue is often faster than the growth rate of human new abdominal wall tissue, which often leads to the failure of such patches

3. When the decellularized tissue is directly used for surgical repair, the material is too dense, and it is difficult for host cells and new tissues to grow into the material, which is not conducive to defect repair

Under the cutting action of sutures or fixation nails during implantation, the hydrogel is easy to tear off, resulting in failure

After implantation, the fatigue resistance of the hydrogel is also insufficient under the repeated stretching motion of the abdominal wall tissue

Moreover, as a scaffold material for abdominal wall tissue engineering, hydrogel itself has shortcomings in promoting tissue regeneration. Abdominal wall tissue has an oriented structure, while hydrogel is a disordered polymer network structure, which is not conducive to the oriented growth of cells, and eventually forms There are also structural differences between the tissue of the human body and the abdominal wall tissue of the human body