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Application of pityriacitrin alkaloids and their derivatives in anti-plant viruses and bacteria

An anti-plant virus, derivative technology, applied in the fields of botanical equipment and methods, chemicals for biological control, applications, etc., can solve the problems of high cost, low synthesis yield, and low natural content of pityriacitrins alkaloids, etc. To achieve good anti-plant virus and bacteria activity, the effect of expanding the scope of application

Active Publication Date: 2021-11-23
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Through literature research, due to the low natural content of pityriacitrins alkaloids, low synthesis yield and high cost, researchers mainly focus on the application of pityriacitrins in medicine, especially anti-tumor, and there are few reports on the control of diseases and insect pests.

Method used

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  • Application of pityriacitrin alkaloids and their derivatives in anti-plant viruses and bacteria
  • Application of pityriacitrin alkaloids and their derivatives in anti-plant viruses and bacteria
  • Application of pityriacitrin alkaloids and their derivatives in anti-plant viruses and bacteria

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The pityriacitrin alkaloids and their derivatives represented by the following 1 to 20 chemical structural formulas of the present invention are obtained by referring to existing literature (Chem.Eur.J.2013,19,10132-10137; RSC Adv.,2014,4,26258- 26263.) prepared by the method disclosed,

[0016]

[0017] in,

[0018] The compound shown in chemical structure formula 1 is pityriacitrin alkaloid,

[0019] The pityriacitrin derivative shown in chemical structural formula 2 is phenyl (9H-pyrido [3,4-b] indol-1-yl) ketone,

[0020] The pityriacitrin derivative shown in chemical structure 3 is (2-chlorophenyl) (9H-pyrido [3,4-b] indol-1-yl) ketone,

[0021] The pityriacitrin derivative shown in chemical structure 4 is (2-bromophenyl) (9H-pyrido [3,4-b] indol-1-yl) ketone,

[0022] The pityriacitrin B derivative shown in chemical structural formula 5 is 1-(1H-indole-3-carbonyl)-9H-pyrido[3,4-b]indole-3-carboxylic acid methyl ester,

[0023] Chemical structural formula 6 ...

Embodiment 2

[0039] The individual compounds of pityriacitrin alkaloids and derivatives thereof shown in the above 1 to 20 chemical structural formulas are used as anti-plant virus agents:

[0040] The measurement of the anti-tobacco mosaic virus activity of the individual compounds of pityriacitrin alkaloids and derivatives thereof shown in the above 1 to 20 chemical structural formulas, the measurement procedure is as follows:

[0041] The first step, tobacco mosaic virus purification and concentration determination:

[0042] Tobacco mosaic virus purification and concentration determination were carried out in accordance with the Tobacco Mosaic Virus SOP specification compiled by the Bioassay Laboratory of the Institute of Elements, Nankai University. After the virus crude extract was centrifuged twice with polyethylene glycol, the measured concentration was 20 μg / mL, and refrigerated at 4 °C spare;

[0043] In the second step, preparation of individual compound medicament solutions of ...

Embodiment 3

[0060] The individual compounds of pityriacitrin alkaloids and derivatives thereof shown in the above 1 to 20 chemical structural formulas are used as phytopathogenic fungicides,

[0061] A. In vitro bactericidal test, bacterial growth rate determination method (plate method):

[0062] The antibacterial activity test of the individual compounds of pityriacitrin alkaloids and derivatives thereof shown in the above 1 to 20 chemical structural formulas, in vitro bactericidal test, the determination procedure is as follows:

[0063] Determination of bacterial growth rate is the plate method: respectively dissolve 3 mg of the individual compounds of pityriacitrin alkaloids and their derivatives shown in the above 1 to 20 chemical structural formulas in 0.03 mL of acetone, and then use 200 μg / mL Tween 80 Dilute the aqueous solution to a test concentration of 50mg / kg, then draw 1mL of the drug solution and inject it into the corresponding Petri dish, then add 9mL of the medium, shake...

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Abstract

The application of pityriacitrin alkaloids and derivatives thereof in anti-plant viruses and germs of the present invention relates to the biocides of pityriacitrin alkaloids and derivatives thereof containing 1-acyl-substituted β-carboline skeletons, specifically twenty kinds of pityriacitrins Alkaloids and derivatives thereof are used as anti-plant virus agents and as phytopathogenic fungicides, said anti-plant virus agents are used for tobacco mosaic virus, pepper virus, rice virus, tomato virus, sweet potato virus, potato virus Virus, melon virus and corn dwarf mosaic virus; described as phytopathogenic fungicide is used to suppress cucumber withering, rice blast, peanut brown spot, apple ring pattern, wheat sheath withered, corn small spot, watermelon anthracnose , Bakanae of rice, tomato early blight, wheat gibberella, potato late blight, capsicum phytophthora, rape sclerotia, cucumber gray mold, rice sheath blight and other 15 kinds of plant pathogens.

Description

technical field [0001] The technical scheme of the present invention relates to the biocides of pityriacitrin alkaloids and derivatives thereof containing 1-acyl substituted β-carboline skeletons, specifically the application of pityriacitrin alkaloids and derivatives thereof in anti-plant viruses and germs. Background technique [0002] Pityriacitrins alkaloids are a class of β-carboline alkaloids with a novel structure, in which an indole structure is linked at the C-1 position of β-carboline through a carbonyl functional group. Compounds containing such core skeletons extracted from nature include pityriacitrin, pityriacitrin B, hytiosulawesine, 7-MeO-pityriacitrin, 7,2'-(MeO) 2 - pityriacitrin and 2'-MeO-6'-OH-pityriacitrin and other pityriacitrins alkaloids (Mini. Rev. Med. Chem., 2021, 21, 233-244.), as shown in structural formula 1. [0003] [0004] Since the Japanese research team first reported the isolation of pityriacitrins alkaloids from the marine bacterium...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/90A01P1/00A01P3/00C07D471/04
CPCA01N43/90C07D471/04
Inventor 卢爱党李林王铁男师利周雅楠苑文英
Owner HEBEI UNIV OF TECH
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