Composition for treating gout as well as preparation method and application thereof

A composition and a technology for gout, which are applied in directions such as drug combinations, medical preparations without active ingredients, and medical preparations containing active ingredients, and can solve problems such as being unsuitable for long-term use.

Pending Publication Date: 2021-08-24
李智民
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are mainly 4 western medicine products among the products for lowering uric acid. However, because patients with hyperuricemia need to take the medicines for lowering uric acid for a long time, and the side effects of western medicine products in terms of liver and kidney toxicity are not suitable for long-term use, suitable Chinese medicine products are needed.

Method used

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  • Composition for treating gout as well as preparation method and application thereof
  • Composition for treating gout as well as preparation method and application thereof
  • Composition for treating gout as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 prepared a composition, and verified the therapeutic effect of the composition on gout. The experimental process is as follows:

[0041] 1. Sources of raw material components, see Table 1 for details.

[0042] Table 1 Sources of raw materials

[0043]

[0044] The preparation method is as follows:

[0045] (1) Extract the lily with water, extract twice at 100°C for 10 hours each time, to obtain extract A, and set aside;

[0046] (2) Mix chicory, coriander root, gardenia, and corn silk, then extract the mixture with water, and extract twice at 100°C for 5 hours each time to prepare extract B for later use;

[0047](3) After pulverizing extract A and extract B, add maltodextrin and L-arabinose and mix thoroughly to obtain mixture C;

[0048] (4) Fill or tablet the mixture C to obtain the corresponding product.

[0049] 2. Test content

[0050] The therapeutic effect on gout of the product prepared above was verified.

[0051] The reagents, animals and ...

Embodiment 2

[0067] Example 2 studied the effects of different treatment groups on the release of macrophage inflammatory factors TNFa and interleukin-6 induced by lipopolysaccharide. The experimental process is as follows:

[0068] Macrophage RAW264.7 cells were pretreated with different concentrations of prescription extract solutions (100 mM, dissolved in ethanol), and after 2 hours, the cells were treated with 10 ng / ml LPS for 48 hours and 72 hours. Collect the cell supernatant, use the ELISA method to detect the inflammatory factors in it: TNF-a, IL-6, test the inhibitory effect of different ratios of decoction on the inflammatory factors released by macrophages stimulated by LPS (lipopolysaccharide) . The results are shown in Table 3 and Table 4 below:

[0069] Table 3: Effects of different components on LPS-induced IL-6 inflammatory factors

[0070]

[0071] Table 4: Effects of different components on LPS-induced TNF-α inflammatory factors

[0072]

[0073]

[0074] The...

Embodiment 3

[0076] Embodiment 3 has tested the product of formula 1 on the patient, as follows:

[0077] Since the product composition is composed of medicinal and food ingredients, it is prepared into food for testing by patients.

[0078] Test population: 100 patients with hyperuricemia

[0079] Test method: fasting fingertip blood. Test fingertip blood on an empty stomach to obtain uric acid value.

[0080] Test equipment: Sinocare uric acid tester, blood collection needle, test strip

[0081] The first test: measure the uric acid value before taking this product, and test again 50 minutes after taking this product, and compare the data before and after.

[0082] The second test: take one bag a day, after taking this product for 30 days continuously, test again on an empty stomach, and compare the data before and after.

[0083] The results of the first test showed that after taking the product of formula 1 for 50 minutes, the uric acid value of 71 people decreased by more than 10%...

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Abstract

The invention provides a composition for treating gout as well as a preparation method and application thereof. The composition comprises the following raw material components of lily, chicory, corn stigma, lalang grass rhizome, cape jasmine, maltodextrin and L-arabinose. Lily, cichorium intybus, corn stigma, lalang grass rhizome and cape jasmine are adopted as traditional Chinese medicine raw material components, and the traditional Chinese medicine composition is green, natural, free of hormone and capable of being used for a long time, and effective components can rapidly reduce the blood uric acid value and relieve pain for gout; the maltodextrin and the L-arabinose are adopted, so that a medicinal preparation is convenient to obtain, and the taste is enhanced.

Description

technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to a composition for treating gout, a preparation method and application. Background technique [0002] Gout is a common and complex type of arthritis that can affect people of all ages. Gout patients often experience sudden joint pain at night. The onset is acute, and severe pain, edema, redness, and inflammation appear in the joints. The pain gradually decreases until it disappears, lasting for several days or weeks. [0003] At present, there are no approval documents for traditional Chinese medicines and health care products with gout as the main function on the market. There are only other analgesic products for external use: among them, Western medicine analgesic products are mainly non-steroidal anti-inflammatory products, which are mainly anti-inflammatory. Although they have a certain analgesic effect, they are not ideal for gout and cannot be used for a long tim...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K47/36A61K47/26A61P19/06
CPCA61K36/28A61K36/744A61K36/8967A61K36/899A61K47/26A61K47/36A61K2236/331A61P19/06A61K2300/00
Inventor 李智民
Owner 李智民
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